The biodisposition and metabolism of anandamide in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 243-247

  Willoughby, Karen A ^a   Moore, Sandra F ^a   Martin, Billy R ^a   Ellis, Earl F ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; DRONABINOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BEHAVIOR; BRAIN REGION; CANNABIS ADDICTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACIDS; BRAIN; CANNABINOIDS; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; POLYUNSATURATED ALKAMIDES; TISSUE DISTRIBUTION;

EID: 0030823213     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. ADAMS, I. B., RYAN, W., SINGER, M., THOMAS, B. F., COMPTON, D. R., RAZDAN, R. K. AND MARTIN, B. R.: Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs. J. Pharmacol. Exp. Ther. 273: 1172-1181, 1995.
2. 1-tetrahydrocannabinol and other cannabinoids with emphasis on man. Pharmacol. Rev. 38: 21-43, 1986.
3. CHAIT, L. D. AND PERRY, J. L.: Acute and residual effects of alcohol and marijuana, alone and in combination, on mood and performance. Psychopharmacology 115: 340-349, 1994.
4. CHILDERS, S. R., SEXTON, T. AND ROY, M. B.: Effects of anandamide on cannabinoid receptors in rat brain membranes. Biochem. Pharmacol. 47: 711-715, 1994.
5. CRAWLEY, J. N., CORWIN, R. L., ROBINSON, J. K., FELDER, C. C., DEVANE, W. A. AND AXELROD, J.: Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents. Pharmacol. Biochem. Behav. 46: 967-972, 1993.
6. DEUTSCH, D. G. AND CHIN, S. A.: Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem. Pharmacol. 46: 791-796, 1993.
7. DEVANE, W. A., HANUS, L., BREUER, A., PERTWEE, R. G., STEVENSON, L. A., GRIFFIN, G., GIBSON, D., MANDELBAUM, A., ETINGER, A. AND MECHOULAM, R.: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (Wash, DC) 258: 1946-1949, 1992.
8. DI MARZO, V., FONTANA, A., CADAS, H., SCHINELLI, S., CIMINO, G., SCHWARTZ, J. AND PILMELLI, D.: Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature (Lond.) 372: 686-689, 1994.
9. 9-THC dilation of cerebral arterioles is blocked by indomethacin. Am. J. Physiol. 269: H1859-H1864, 1995.
10. ESPLIN, B. AND CAPEK, R.: Quantitative characterization of the THC and ethanol interaction. Res. Commun. Chem. Pathol. Pharmacol. 15: 199-202, 1976.
11. FRIDE, E. AND MECHOULAM, R.: Pharmacological activity of the cannabinoid receptor agonist anandamide, a brain constituent. Eur. J. Pharmacol. 231: 313-314, 1993.
12. HILLIARD, C. E., WILKINSON, D. M., EDGEMOND, W. S. AND CAMPBELL, W. B.: Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. Biochim. Biophys. Acta. 1257: 249-256, 1995.
13. NATARAJAN, V., SCHMID, P. C., REDDY, P. V. AND SCHMID, H. O.: Catabolism of n-acylethanolamine phospholipids by dog brain preparation. J. Neurochem. 42: 1613-1619, 1984.
14. SCHMID, P. C., ZUZARTE-AUGUSTIN, M. L. AND SCHMID, H. O.: Properties of rat liver N-acylethanolamine aminohydrolase. J. Biol. Chem. 260: 14145-14149, 1985.
15. 9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-m ethyl-1H-pyrazole-3-carboximide hydrochloride]. Biochem. Pharmacol. 51: 669-676, 1996.
16. SMITH, P. B., COMPTON, D. R., WELCH, S. P., RAZDAN, R. K., MECHOULAM, R. AND MARTIN, B. R.: The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. J. Pharmacol. Exp. Ther. 270: 219-227, 1994.