Peroxisome proliferator-activated receptor-γ modulates differentiation of human trophoblast in a ligand-specific manner

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 10, 2000, Pages 3874-3881

  Schaiff, W Timothy ^a   Carlson, Matthew G ^a   Smith, Steven D ^a   Levy, Roni ^a   Nelson, D Michael ^a   Sadovsky, Yoel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROSTAGLANDIN J2; PROTEIN P53; TROGLITAZONE;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOTROPHOBLAST; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PLACENTA VILLUS; PRIORITY JOURNAL; SYNCYTIOTROPHOBLAST; TROPHOBLAST;

EID: 0033763069     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.85.10.6885     Document Type: Article

References (55)

1. Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions
2. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
3. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat
4. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors
5. mPPARγ 2: Tissue-specific regulator of an adipocyte enhancer
6. Peroxisome proliferator-activated receptor (PPAR) γ: Adipose- predominant expression and induction early in adipocyte differentiation
7. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
8. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
9. Activation of proliferator-activated receptors a and g induces apoptosis of human monocyte-derived macrophages
10. A human peroxisome-proliferator-activated receptor-γ is activated by inducers of adipogenesis, including thiazolidinedione drugs
11. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
12. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
13. 2 is a ligand for the adipocyte determination factor PPARγ
14. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
15. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ)
16. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones
17. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
18. Differential activation of peroxisome proliferator-activated receptors by eicosanoids
19. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα
20. Terminal differentiation of human breast cancer through PPARγ
21. PPARγ is required for placental, cardiac, and adipose tissue development
22. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
23. Purification, characterization and in vitro differentiation of cytotrophoblasts from human term placentae
24. Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta
25. Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro
26. Two cis-acting regulatory sequences in the peroxisome proliferator- responsive enhancer region of rat acyl-CoA oxidase gene
27. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
28. DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region
29. A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally
30. Transcriptional regulation of prostaglandin-H synthase-2 gene in human trophoblasts
31. High-efficiency transformation of mammalian cells by plasmid DNA
32. Expression patterns of the cell-cycle inhibitor p27 and the cell-cycle promoter cyclin E in the human placenta throughout gestation: Implications for the control of proliferation
33. Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro
34. Differentiation of human trophoblast cells in vitro as revealed by immunocytochemical staining of desmoplakin and nuclei
35. A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation
36. 2, a ligand for peroxisome proliferator-activated receptor-γ, induces apoptosis in JEG3 choriocarcinoma cells
37. Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells
38. 2
39. p53 and apoptosis
40. p53-induced apoptosis as a safeguard against cancer
41. Peroxisome proliferators and retinoids affect JEG-3 choriocarcinoma cell function
42. Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta
43. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
44. Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
45. Regulation of peroxisome proliferator-activated receptor g activity by mitogen-activated protein kinase
46. 2 in transformed endothelial cells
47. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
48. Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens
49. 2
50. 2 integrin-dependent oxidative burst: Involvement of a mechanism distinct from peroxisome proliferator-activated receptor g ligation
51. Activation of peroxisome proliferator-activated receptor g does not inhibit IL-6 or TNF-α responses of macrophages to lipopolysaccharide in vitro or in vivo
52. Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-γ
53. Placental pathology of fetal growth restriction
54. Placental pathology in obstetrics: Adaptation or failure of the villous tree?
55. Increased placenta apoptosis in intrauterine growth restriction