메뉴 건너뛰기




Volumn 19, Issue 1, 1999, Pages 35-46

The influence of base sequence on the immunostimulatory properties of DNA

Author keywords

Antisense; Cytokines; DNA; Host defense; Immunostimulation; Phosphorothioates

Indexed keywords

BACTERIAL DNA; CYTOSINE; DEOXYGUANOSINE; DINUCLEOTIDE; DNA; DNA BASE; GUANINE; OLIGONUCLEOTIDE;

EID: 0033065988     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786475     Document Type: Review
Times cited : (25)

References (60)
  • 1
    • 0026556987 scopus 로고
    • Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
    • Tokunaga T, Yano O, Kuramoto E, Kimura Y, Yamamoto T, Kataoka T, et al.: Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol Immunol 1992;36:55-66.
    • (1992) Microbiol Immunol , vol.36 , pp. 55-66
    • Tokunaga, T.1    Yano, O.2    Kuramoto, E.3    Kimura, Y.4    Yamamoto, T.5    Kataoka, T.6
  • 4
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky DS: Immune activation by bacterial DNA: A new genetic code. Immunity 1996;5:303-310.
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 5
    • 0030070364 scopus 로고    scopus 로고
    • The immunologic properties of DNA
    • Pisetsky DS: The immunologic properties of DNA. J Immunol 1996;156:421-423.
    • (1996) J Immunol , vol.156 , pp. 421-423
    • Pisetsky, D.S.1
  • 6
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T, Yamamoto II, Shimada S, Abe H, Fukuda T, Fujisawa Y, et al.: Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Can Inst 1984;72: 955-962.
    • (1984) J Natl Can Inst , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, I.I.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6
  • 7
    • 0021957292 scopus 로고
    • Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors
    • Shimada S, Yano O, lnoue H, Kuramoto E, Fukuda T, Yamamote H, et al.: Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors. J Natl Can Inst 1985;74:681-688.
    • (1985) J Natl Can Inst , vol.74 , pp. 681-688
    • Shimada, S.1    Yano, O.2    Lnoue, H.3    Kuramoto, E.4    Fukuda, T.5    Yamamote, H.6
  • 8
    • 0013614174 scopus 로고
    • Influence of oligodeoxyribonucleotides on early events in antibody formation
    • Braun W, Nakano M: Influence of oligodeoxyribonucleotides on early events in antibody formation. Proc SocExpBiol Med 1965; 119:701-707.
    • (1965) Proc SocExpBiol Med , vol.119 , pp. 701-707
    • Braun, W.1    Nakano, M.2
  • 9
    • 0015840482 scopus 로고
    • Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. II. Relationship between adjuvant activity and stimulation of DNA synthesis by polyanions
    • Vogt W, Ruhl H, Wagner B, Diamantstein T: Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. II. Relationship between adjuvant activity and stimulation of DNA synthesis by polyanions. Eur J Immunol 1973;3:493-496.
    • (1973) Eur J Immunol , vol.3 , pp. 493-496
    • Vogt, W.1    Ruhl, H.2    Wagner, B.3    Diamantstein, T.4
  • 10
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce INF and augment INF-mediated natural killer activity
    • Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O, Tokunaga T: Unique palindromic sequences in synthetic oligonucleotides are required to induce INF and augment INF-mediated natural killer activity. J Immunol 1992; 148:4072-4076.
    • (1992) J Immunol , vol.148 , pp. 4072-4076
    • Yamamoto, S.1    Yamamoto, T.2    Kataoka, T.3    Kuramoto, E.4    Yano, O.5    Tokunaga, T.6
  • 11
    • 0027978749 scopus 로고
    • Synthetic oligonucleotides with certain palindromes stimulate inteferon production of human peripheral blood lymphocytes in vitro
    • Yamamoto T, Yamamoto S, Kataoka T, Komuro K, Kohase M, Tokunaga T: Synthetic oligonucleotides with certain palindromes stimulate inteferon production of human peripheral blood lymphocytes in vitro. Jpn J Cancer Res 1994;85:775-779.
    • (1994) Jpn J Cancer Res , vol.85 , pp. 775-779
    • Yamamoto, T.1    Yamamoto, S.2    Kataoka, T.3    Komuro, K.4    Kohase, M.5    Tokunaga, T.6
  • 12
    • 0026464967 scopus 로고
    • DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
    • Yamamoto S, Yamamoto T, Shimada S, Kuramoto E, Yano O. Kataoka T, et al.: DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol Immunol 1992;36:983-997.
    • (1992) Microbiol Immunol , vol.36 , pp. 983-997
    • Yamamoto, S.1    Yamamoto, T.2    Shimada, S.3    Kuramoto, E.4    Yano, O.5    Kataoka, T.6
  • 13
    • 0026006734 scopus 로고
    • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
    • Messina JP, Gilkeson GS, Pisetsky DS: Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol 1991;147:1759-1764.
    • (1991) J Immunol , vol.147 , pp. 1759-1764
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 14
    • 0030028722 scopus 로고    scopus 로고
    • Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α
    • Halpern MD, Kurlander RJ, Pisetsky DS: Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell Immunol 1996;167:72-78.
    • (1996) Cell Immunol , vol.167 , pp. 72-78
    • Halpern, M.D.1    Kurlander, R.J.2    Pisetsky, D.S.3
  • 15
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs presents in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
    • Klinman DM, Yi A-K, Beaucage SL, Conover J, Krieg AM: CpG motifs presents in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc Natl Acad Sci USA 1996;93:2879-2883.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.-K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 16
    • 0029934754 scopus 로고    scopus 로고
    • Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides
    • Cowdery JS, Chace JH, Yi A-K, Krieg AM: Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J Immunol 1996; 156:4570-4575.
    • (1996) J Immunol , vol.156 , pp. 4570-4575
    • Cowdery, J.S.1    Chace, J.H.2    Yi, A.-K.3    Krieg, A.M.4
  • 17
    • 0029670726 scopus 로고    scopus 로고
    • IFN-γ promotes IL-6 IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
    • Yi A-K, Chace JH, Cowdery JS, Krieg AM: IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J Immunol 1996;156:558-564.
    • (1996) J Immunol , vol.156 , pp. 558-564
    • Yi, A.-K.1    Chace, J.H.2    Cowdery, J.S.3    Krieg, A.M.4
  • 19
    • 0023472826 scopus 로고
    • CpG islands as gene markers in the vertebrate nucleus
    • Bird AP: CpG islands as gene markers in the vertebrate nucleus. Trends Genet 1987;3:342-346.
    • (1987) Trends Genet , vol.3 , pp. 342-346
    • Bird, A.P.1
  • 20
    • 0025786059 scopus 로고
    • Biological aspects of cytosine methylation in eukaryotic cells
    • Hergersberg M: Biological aspects of cytosine methylation in eukaryotic cells. Experientia 1991;47: 1171-1185.
    • (1991) Experientia , vol.47 , pp. 1171-1185
    • Hergersberg, M.1
  • 21
    • 0026502711 scopus 로고
    • Over- and under-representation of short oligonucleotidcs in DNA sequences
    • Burge C, Campbell AM, Karlin S: Over- and under-representation of short oligonucleotidcs in DNA sequences. Proc Natl Acad Sci USA 1992;89:1358-1362.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1358-1362
    • Burge, C.1    Campbell, A.M.2    Karlin, S.3
  • 22
    • 0027887302 scopus 로고
    • Functions for DNA methylation in vertebrates
    • Bird AP: Functions for DNA methylation in vertebrates. Cold Harbor Symp Quant Biol 1993; 58:281-285.
    • (1993) Cold Harbor Symp Quant Biol , vol.58 , pp. 281-285
    • Bird, A.P.1
  • 23
    • 0026201153 scopus 로고
    • Patterns of DNA methylation - Evolutionary vestiges of foreign DNA inactivation as a host defense mechanism. A proposal
    • Doerfler W: Patterns of DNA methylation - Evolutionary vestiges of foreign DNA inactivation as a host defense mechanism. A proposal. Biol Chem Hoppe-Seyler 1991;372:557-564.
    • (1991) Biol Chem Hoppe-Seyler , vol.372 , pp. 557-564
    • Doerfler, W.1
  • 24
    • 0031252286 scopus 로고    scopus 로고
    • Mitogenicity of DNA from different organisms for murine B cells
    • Sun S, Beard C, Jaenisch R, Jones P, Sprent J: Mitogenicity of DNA from different organisms for murine B cells. J Immunol 1997;159:3119-3125.
    • (1997) J Immunol , vol.159 , pp. 3119-3125
    • Sun, S.1    Beard, C.2    Jaenisch, R.3    Jones, P.4    Sprent, J.5
  • 25
    • 0027672189 scopus 로고
    • Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides
    • Pisetsky DS, Reich C: Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides. Mol Biol Rep 1993;18:217-221.
    • (1993) Mol Biol Rep , vol.18 , pp. 217-221
    • Pisetsky, D.S.1    Reich, C.2
  • 26
    • 0027413599 scopus 로고
    • The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens
    • Messina JP. Gilkeson GS, Pisetsky DS: The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens. Cell Immunol 1993;147:148-157.
    • (1993) Cell Immunol , vol.147 , pp. 148-157
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 27
    • 0027945606 scopus 로고
    • Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN
    • Kimura Y, Sonehara K, Kuramoto E, Makino T, Yamamoto S, Yamamoto T, et al.: Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN. J Biochem 1994;116:991-994.
    • (1994) J Biochem , vol.116 , pp. 991-994
    • Kimura, Y.1    Sonehara, K.2    Kuramoto, E.3    Makino, T.4    Yamamoto, S.5    Yamamoto, T.6
  • 29
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian VA: Telomeres: Beginning to understand the end. Science 1995;270:1601-1607.
    • (1995) Science , vol.270 , pp. 1601-1607
    • Zakian, V.A.1
  • 30
    • 0025177343 scopus 로고
    • Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
    • Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M: Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils. Nature 1990;343:531-535.
    • (1990) Nature , vol.343 , pp. 531-535
    • Kodama, T.1    Freeman, M.2    Rohrer, L.3    Zabrecky, J.4    Matsudaira, P.5    Krieger, M.6
  • 31
    • 0028173897 scopus 로고
    • Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
    • Krieger M, Herz J: Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 1994;63:601-637.
    • (1994) Annu Rev Biochem , vol.63 , pp. 601-637
    • Krieger, M.1    Herz, J.2
  • 32
    • 0027468768 scopus 로고
    • Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quarter-stabilized four-stranded helices
    • Pearson AM, Rich A, Krieger M: Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quarter-stabilized four-stranded helices. J Biol Chem 1993;268:3546-3554.
    • (1993) J Biol Chem , vol.268 , pp. 3546-3554
    • Pearson, A.M.1    Rich, A.2    Krieger, M.3
  • 33
    • 0030702820 scopus 로고    scopus 로고
    • The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock
    • Haworth R, Platt N, Keshav S, Hughes D, Darley E, Suzuki H, et al.: The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med 1997;186:1431-1439.
    • (1997) J Exp Med , vol.186 , pp. 1431-1439
    • Haworth, R.1    Platt, N.2    Keshav, S.3    Hughes, D.4    Darley, E.5    Suzuki, H.6
  • 34
    • 0022486984 scopus 로고
    • Receptor recognition of malcyl-albumin induces chemotaxis in human monocytes
    • Haberland ME, Rasmussen RR, Fogelman AM: Receptor recognition of malcyl-albumin induces chemotaxis in human monocytes. J Clin Invest 1986;78:827-831.
    • (1986) J Clin Invest , vol.78 , pp. 827-831
    • Haberland, M.E.1    Rasmussen, R.R.2    Fogelman, A.M.3
  • 35
    • 0025021490 scopus 로고
    • Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937
    • Frostegard J, Nilsson J, Haegerstrand A, Hamsten A, Wigzell H, Gidlund M: Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. Proc Natl Acad Sci 1990;87:904-908.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 904-908
    • Frostegard, J.1    Nilsson, J.2    Haegerstrand, A.3    Hamsten, A.4    Wigzell, H.5    Gidlund, M.6
  • 36
    • 0345516037 scopus 로고    scopus 로고
    • The influence of base sequence on the immunological properties of defined oligonucleotides
    • Pisetsky DS, Reich CF: The influence of base sequence on the immunological properties of defined oligonucleotides. Immunopharmacology 1998;40:199-208.
    • (1998) Immunopharmacology , vol.40 , pp. 199-208
    • Pisetsky, D.S.1    Reich, C.F.2
  • 38
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi A-K, Tuetken R, Redford T, Waldschmidt M, Kirsch J. Krieg AM: CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J Immunol 1998;160:4755-4761.
    • (1998) J Immunol , vol.160 , pp. 4755-4761
    • Yi, A.-K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6
  • 40
    • 0029080474 scopus 로고
    • Exposing the immunology of naked DNA vaccines
    • Pardoll DM, Beckerleg AM: Exposing the immunology of naked DNA vaccines. Immunity 1995;3:165-169.
    • (1995) Immunity , vol.3 , pp. 165-169
    • Pardoll, D.M.1    Beckerleg, A.M.2
  • 41
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
    • Corr M, Lee DJ, Carson DA, Tighe H: Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J Exp Mud 1996;184:1555-1560.
    • (1996) J Exp Mud , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3    Tighe, H.4
  • 42
    • 0031178797 scopus 로고    scopus 로고
    • The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
    • Iwasaki A, Torres CAT, Ohashi PS, Robinson HL, Barber BH: The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. J Immunol 1997;159:11-14.
    • (1997) J Immunol , vol.159 , pp. 11-14
    • Iwasaki, A.1    Torres, C.A.T.2    Ohashi, P.S.3    Robinson, H.L.4    Barber, B.H.5
  • 43
    • 8944253295 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
    • Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M-D, et al.: Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996;273:352-354.
    • (1996) Science , vol.273 , pp. 352-354
    • Sato, Y.1    Roman, M.2    Tighe, H.3    Lee, D.4    Corr, M.5    Nguyen, M.-D.6
  • 44
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM, Yamshchikov G, Ishigatsubo Y: Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 1997;158:3635-3639.
    • (1997) J Immunol , vol.158 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 45
    • 0032125838 scopus 로고    scopus 로고
    • The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors
    • Wloch MK, Pasquini S, Ertl HCJ, Pisetsky DS: The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. Hum Gent Ther 1998;9:1439-1447.
    • (1998) Hum Gent Ther , vol.9 , pp. 1439-1447
    • Wloch, M.K.1    Pasquini, S.2    Ertl, H.C.J.3    Pisetsky, D.S.4
  • 46
    • 0029049810 scopus 로고
    • The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake
    • Kawabata K, Takakura Y, Hashida M: The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake. Pharm Res 1995;12:825-830.
    • (1995) Pharm Res , vol.12 , pp. 825-830
    • Kawabata, K.1    Takakura, Y.2    Hashida, M.3
  • 47
    • 0030440928 scopus 로고    scopus 로고
    • Diposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake
    • Sawai K, Mahato RI, Oka Y, Takakura Y, Hashida M: Diposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake. J Pharmacol Exp Ther 1996;279:284-290.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 284-290
    • Sawai, K.1    Mahato, R.I.2    Oka, Y.3    Takakura, Y.4    Hashida, M.5
  • 48
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents - Is the bullet really magical?
    • Stein CA. Cheng YC: Antisense oligonucleotides as therapeutic agents - Is the bullet really magical? Science 1993;261:1004-1012.
    • (1993) Science , vol.261 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.C.2
  • 49
    • 0022418143 scopus 로고
    • Bond order and charge localization in nucleoside phosphorothioates
    • Frey PA, Sammons RD: Bond order and charge localization in nucleoside phosphorothioates. Science 1985;228:541-545.
    • (1985) Science , vol.228 , pp. 541-545
    • Frey, P.A.1    Sammons, R.D.2
  • 50
    • 0024296609 scopus 로고
    • Physicochemical properties of phosphorothioate oligodeoxynucleotides
    • Stein CA, Subasinghe C, Shinozuka K. Cohen JS: Physicochemical properties of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res 1988;16:3209-3221.
    • (1988) Nucleic Acids Res , vol.16 , pp. 3209-3221
    • Stein, C.A.1    Subasinghe, C.2    Shinozuka, K.3    Cohen, J.S.4
  • 51
    • 0029664297 scopus 로고    scopus 로고
    • Preferential induction of a Thl immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
    • Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, et al.: Preferential induction of a Thl immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA 1996;93:5141-5145.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5141-5145
    • Raz, E.1    Tighe, H.2    Sato, Y.3    Corr, M.4    Dudler, J.A.5    Roman, M.6
  • 52
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K: CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants. Eur J Immunol 1997;27:2340-2344.
    • (1997) Eur J Immunol , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 53
    • 0032489829 scopus 로고    scopus 로고
    • DNA as an adjuvant: Capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen
    • Sun S, Kishimoto H, Sprent J: DNA as an adjuvant: Capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J Exp Med 1998;187:1145-1150.
    • (1998) J Exp Med , vol.187 , pp. 1145-1150
    • Sun, S.1    Kishimoto, H.2    Sprent, J.3
  • 54
    • 0032521881 scopus 로고    scopus 로고
    • Cutting Edge: CpG oligodeoxynucleotides trigger protective and curative Thl responses in lethal murine Leishmaniasis
    • Zimmermann S, Egeter O, Hausmann S, Lipford GB, Rocken M, Wagner H, et al.: Cutting Edge: CpG oligodeoxynucleotides trigger protective and curative Thl responses in lethal murine Leishmaniasis. J Immunol 1998;160: 3627-3630.
    • (1998) J Immunol , vol.160 , pp. 3627-3630
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3    Lipford, G.B.4    Rocken, M.5    Wagner, H.6
  • 56
    • 0030071007 scopus 로고    scopus 로고
    • Effect of different chemically modified oligodeoxynucleotides on immune stimulation
    • Zhao Q, Temsamani J, Iadamla PL, Jiang Z, Agrawal S: Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem Pharm 1996;51:173-182.
    • (1996) Biochem Pharm , vol.51 , pp. 173-182
    • Zhao, Q.1    Temsamani, J.2    Iadamla, P.L.3    Jiang, Z.4    Agrawal, S.5
  • 59
    • 0028114548 scopus 로고
    • Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding
    • Brown DA, Kang S-H, Gryaznov SM, Dedionisio L, Heidenreich O, Sullivan S, et al.: Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J Biol Chem 1994;269:26,801-26,805.
    • (1994) J Biol Chem , vol.269 , pp. 26801-26805
    • Brown, D.A.1    Kang, S.-H.2    Gryaznov, S.M.3    Dedionisio, L.4    Heidenreich, O.5    Sullivan, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.