Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages

Journal of Virology

Volumn 74, Issue 22, 2000, Pages 10852-10859

  Mori, K ^a   Rosenzweig, M ^a   Desrosiers, R C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; VIRUS DNA;

ADAPTATION; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; DNA SYNTHESIS; FLOW CYTOMETRY; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE FUNCTION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIRUS REPLICATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGENS, VIRAL; CELLS, CULTURED; DNA, VIRAL; HUMANS; MACACA MULATTA; MACROPHAGES, ALVEOLAR; RNA, VIRAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 0033762172     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.22.10852-10859.2000     Document Type: Article

References (66)

1. IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages
2. Recombinant simian immunodeficiency virus expressing green fluorescent protein identifies infected cells in rhesus monkeys
3. Analysis of envelope changes acquired by SIVmac239 during neuroadaption in rhesus macaques
4. In vitro and in vivo infection of rhesus monkey microglial cells by simian immunodeficiency virus
5. Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys
6. V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1
7. Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor
8. Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types
9. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals
10. Identification of a major co-receptor for primary isolates of HIV-1
11. Expression cloning of new receptors used by simian and human immunodeficiency viruses
12. Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS
13. A dual-tropic primary HIV-1 isolate that uses fusion and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
14. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
15. Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains
16. Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains
17. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain
18. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4
19. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection
20. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
21. The role of mononuclear phagocytes in HTLV-III/LAV infection
22. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
23. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome
24. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1
25. Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors
26. Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1
27. Importance of the nef gene for maintenance of high virus loads and for the development of AIDS
28. The V3 domain is a determinant of simian immunodeficiency virus cell tropism
29. Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry
30. Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDS
31. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
32. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms
33. Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor down-regulation
34. Upregulation of beta-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates
35. Induction of inhibitory antibodies to the CCR5 chemokine receptor and their complementary role in preventing SIV infection in macaques
36. Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms
37. Surface CD4 is critical to in vitro HIV infection of human alveolar macrophages
38. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1
39. Bone marrow monocyte/macrophages are an early cellular target of pathogenic and nonpathogenic isolates of simian immunodeficiency virus (SIVmac) in rhesus macaques
40. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239
41. CD4-independent binding of SIV gp120 to rhesus CCR5
42. Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined by env but is not due to restricted entry
43. Complex determinants of macrophage tropism in env of simian immunodeficiency virus
44. Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: Persistent infection of rhesus monkeys with molecularly cloned SIVmac
45. HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain
46. + lymphoid cell line
47. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
48. Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry
49. Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo
50. Mannose receptor
51. Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: Comparison with HIV-1 and simian immunodeficieney virus and relevance to cell tropism in vivo
52. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus
53. Use of human leukocyte-specific monoclonal antibodies for clinically immunophenotyping lymphocytes of rhesus monkeys
54. The productive infection of alveolar macrophages by simian immunodeficiency virus
55. Efficient and durable gene marking of hematopoietic progenitor cells in nonhuman primates after nonablative conditioning
56. Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection
57. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity
58. Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells
59. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
60. Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia
61. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene
62. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
63. Biology of adult human microglia in culture: Comparisons with peripheral blood monocytes and astrocytes
64. Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages
65. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
66. p21-containing cyclin kinases exist in both active and inactive states