Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 278, Issue 1 47-1, 2000, Pages

  Tune, Johnathan D ^a   Richmond, Keith Neu ^a   Gorman, Mark W ^a   Olsson, Ray A ^b   Feigl, Eric O ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

8 phenyltheophylline; 8 sulfophenyltheophylline; Myocardial blood flow

Indexed keywords

8 (4 SULFOPHENYL)THEOPHYLLINE; 8 PHENYLTHEOPHYLLINE; ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA PRESSURE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; DOSE RESPONSE; EXERCISE; HEART RATE; MALE; METABOLIC REGULATION; NONHUMAN; OXYGEN CONSUMPTION; PREDICTION; PRIORITY JOURNAL; RECEPTOR BLOCKING; TREADMILL;

EID: 0033952435     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.278.1.h74     Document Type: Article

References (34)

1. Bache, R. J., X.-Z. Dai, J. S. Schwartz, and D. C. Homans. Role of adenosine in coronary vasodilation during exercise. Circ. Res. 62: 846-853, 1988.
2. Berne, R. M. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am. J. Physiol. 204: 317-322, 1963.
3. Broten, T. P., J. L. Romson, D. A. Fullerton, D. M. Van Winkle, and E. O. Feigl. Synergistic action of myocardial oxygen and carbon dioxide in controlling coronary blood flow. Circ. Res. 68: 531-542, 1991.
4. 2-adenosine receptors. J. Med. Chem. 28: 487-492, 1985.
5. Drake-Holland, A. J., J. D. Laird, M. I. M. Noble, J. A. E. Spaan, and I. Vergroesen. Oxygen and coronary vascular resistance during autoregulation and metabolic vasodilatation in the dog. J. Physiol. (Lond.) 348: 285-300, 1984.
6. Duncker, D. J., R. Stubenitsky, and P. D. Verdouw. Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise. Am. J. Physiol. Heart Circ. Physiol. 275: H1663-H1672, 1998.
7. ATP channel blockade. J. Clin. Invest. 95: 285-295, 1995.
8. Edlund, A., T. Conradsson, and A. Sollevi. A role for adenosine in coronary vasoregulation in man. Effects of theophylline and enprofylline. Clin. Physiol. 15: 623-636, 1995.
9. Edlund, A., and A. Sollevi. Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation. Acta Physiol. Scand. 155: 303-311, 1995.
10. Ely, S. W., R. M. Knabb, A. N. Bacchus, R. Rubio, and R. M. Berne. Measurements of coronary plasma and pericardial infusate adenosine concentrations during exercise in conscious dog: relationship to myocardial oxygen consumption and coronary blood flow. J. Mol. Cell. Cardiol. 15: 673-683, 1983.
11. Fanton, J. W., L. E. Lott, K. A. Lott, C. Reister, C. D. White, and R. D. Latham. A method for repeated high-fidelity micromanometer measurements of intracardiac pressures. J. Invest. Surg. 9: 167-173, 1995.
12. Gerlach, E., B. Deuticke, and R. H. Dreisbach. Der Nucleotid-Abbau im Herzmuskel bei Sauerstoffmangel und seine mögliche Bedeutung für die Coronardurchblutung. Naturwissenschaften 50: 228-229, 1963.
13. Gorman, M. W., R. D. Wangler, J. B. Bassingthwaighte, D. E. Mohrman, C. Y. Wang, and H. V. Sparks. Interstitial adenosine concentration during norepinephrine infusion in isolated guinea pig hearts. Am. J. Physiol. Heart Circ. Physiol. 261: H901-H909, 1991.
14. Headrick, J. P., S. W. Ely, G. P. Matherne, and R. M. Berne. Myocardial adenosine, flow, and metabolism during adenosine antagonism and adrenergic stimulation. Am. J. Physiol. Heart Circ. Physiol. 264: H61-H70, 1993.
15. Held-Munzenmaier, D., G. N. Olinger, and L. E. Boerboom. A sheath for repetitive insertion of high-fidelity micromanometer-tipped catheters. Am. J. Physiol. Heart Circ. Physiol. 257: H1312-H1314, 1989.
16. Heller, L. J., W. P. Dole, and D. E. Mohrman. Adenosine receptor blockade enhances isoproterenol-induced increases in cardiac interstitial adenosine. J. Mol. Cell. Cardiol. 23: 887-898, 1991.
17. Herrmann, S. C., and E. O. Feigl. Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia. Circ. Res. 70: 1203-1216, 1992.
18. Herrmann, S. C., and E. O. Feigl. Subtraction method for the high-performance liquid chromatographic measurement of plasma adenosine. J. Chromat. 574: 247-253, 1992.
19. Kroll, K., A. Deussen, and I. R. Sweet. Comprehensive model of transport and metabolism of adenosine and S-adenosylhomocysteine in the guinea pig heart. Circ. Res. 71: 590-604, 1992.
20. Kroll, K., and E. O. Feigl. Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts. Am. J. Physiol. Heart Circ. Physiol. 249: H1176-H1187, 1985.
21. Kroll, K., and D. W. Stepp. Adenosine kinetics in the canine coronary circulation. Am. J. Physiol. Heart Circ. Physiol. 270: H1469-H1483, 1996.
22. 2 utilisation efficiency in isoprenaline-stimulated canine myocardium. Cardiovasc. Res. 31: 102-116, 1996.
23. McKenzie, J. E., R. P. Steffen, and F. J. Haddy. Relationships between adenosine and coronary resistance in conscious exercising dogs. Am. J. Physiol. Heart Circ. Physiol. 242: H24-H29, 1982.
24. McKenzie, J. E., R. P. Steffen, and F. J. Haddy. Effect of theophylline on adenosine production in the canine myocardium. Am. J. Physiol. Heart Circ. Physiol. 252: H204-H210, 1987.
25. Merrill, G. F., H. F. Downey, and C. E. Jones. Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia. Am. J. Physiol. Heart Circ. Physiol. 250: H579-H583, 1986.
26. Nees, S., V. Herzog, B. F. Becker, M. Böck, C. Des Rosiers, and E. Gerlach. The coronary endothelium: a highly active metabolic barrier for adenosine. Basic Res. Cardiol. 80: 515-529, 1985.
27. Ontyd, J., and J. Schrader. Measurement of adenosine, inosine, and hypoxanthine in human plasma. J. Chromat. 307: 404-409, 1984.
28. Roux, S., V. Breu, T. Giller, W. Neidhart, H. Ramuz, P. Coassolo, J. P. Clozel, and M. Clozel. Ro-61 - 1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm. J. Pharmacol. Exp. Ther. 283: 1110-1118, 1997.
29. ATP channels and adenosine are not necessary for coronary autoregulation. Am. J. Physiol. Heart Circ. Physiol. 273: H1299-H1308, 1997.
30. Stepp, D. W., R. Van Bibber, K. Kroll, and E. O. Feigl. Quantitative relation between interstitial adenosine concentration and coronary blood flow. Circ. Res. 79: 601-610, 1996.
31. Van Bibber, R., D. W. Stepp, K. Kroll, and E. O. Feigl. The role of adenosine in norepinephrine-induced coronary vasodilation. Am. J. Physiol. Heart Circ. Physiol. 273: H557-H565, 1997.
32. Van Bibber, R., O. Traub, K. Kroll, and E. O. Feigl. EDRF and norepinephrine-induced coronary vasodilation in the canine coronary circulation. Am. J. Physiol. Heart Circ. Physiol. 268: H1973-H1981, 1995.
33. Velasco, C. E., E. K. Jackson, J. A. Morrow, J. V. Vitola, T. Inagami, and M. B. Forman. Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischaemia and reperfusion. Cardiovasc. Res. 27: 121-128, 1993.
34. Yada, T., K. N. Richmond, R. Van Bibber, K. Kroll, and E. O. Feigl. Role of adenosine in local metabolic coronary vasodilation. Am. J. Physiol. Heart Circ. Physiol. 276: H1425-H1433, 1999.