Road signs guiding leukocytes along the inflammation superhighway

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 5, 2000, Pages 817-828

  Bochner, Bruce S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adhesion molecules; Chemokines; Eosinophils; Gastrointestinal tract; Homing; Lung; Lymph nodes; Lymphocytes; Recruitment; Skin

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCYTE CHEMOTACTIC PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

CELL COMPARTMENTALIZATION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOGENESIS; INFLAMMATION; LEUKOCYTOSIS; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; REVIEW; TISSUE SPECIFICITY;

EID: 0033709908     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.110813     Document Type: Article

References (151)

1. Historic highlights
2. Chemokines and allergic disease
3. Chemokines: Signal lamps for trafficking of T and B cells for development and effector function
4. Development and maturation of secondary lymphoid tissues
5. Chemokines and cell migration in secondary lymphoid organs
6. Lymphocyte trafficking and regional immunity
7. The role of chemokine receptors in primary, effector, and memory immune responses
8. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
9. CCL chemokines and asthma
10. Cellular adhesion in inflammation
11. Demonstration that a lectin-like receptor (gp90(MEL)) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes
12. Control of lymphocyte recirculation in man, I: Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition
13. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors
14. Comparison of human eosinophil and neutrophil adhesion to endothelial cells under non-static conditions: The role of L-selectin
15. Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGl-1, CD162) and adhesion to P-selectin in vitro
16. Comparison of tethering and rolling of eosinophils and neutrophils through selectins and P-selectin glycoprotein ligand-1
17. Molecular basis for selective eosinophil trafficking in asthma: A multistep paradigm
18. Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis(x) antagonist TBC1269: Preferential activity against neutrophil adhesion in vitro
19. Expression of P-selectin at low site density promotes selective attachment of eosinophils over neutrophils
20. Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin - A juxtacrine system for adhesion and activation of neutrophils
21. Cysteinyl leukotrienes induce P-selectin expression in cultured endothelial cells via a non-CysLT1 receptor-mediated mechanism
22. Differences between human eosinophils and neutrophils in the function and expression of sialic acid-containing counterligands for E-selectin
23. The dynamic regulation of integrin adhesiveness
24. Chemokines: A new classification system and their role in immunity
25. Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors
26. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration
27. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3 beta receptor CCR7
28. Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow
29. Differential regulation of β1 and β2 integrin avidity by chemoattractants in eosinophils
30. The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow
31. CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro
32. Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration
33. Leukocyte polarization in cell migration and immune interactions
34. Mechanisms of disease: Chemokines - Chemotactic cytokines that mediate inflammation
35. Chemokine receptors
36. Eosinophil-endothelial interactions and transendothelial migration
37. Migration of eosinophils across endothelial cell monolayers: Interactions among IL-5, endothelial-activating cytokines, and C-C chemokines
38. αdβ2 Integrin is expressed on human eosinophils and functions as an alternative ligand for VCAM-1
39. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
40. Chemokines and chemokine receptors in T-cell priming and Th1/Th2- mediated responses
41. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells
42. Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo
43. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics
44. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
45. A cell-surface molecule involved in organ-specific homing of lymphocytes
46. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
47. Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing
48. Genetic defect in T lymphocyte-specific homing into peripheral lymph nodes
49. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
50. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes
51. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
52. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules
53. The role of CCR7 in T(H)1 and T(H)2 cell localization and delivery of B cell help in vivo
54. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
55. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
56. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
57. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
58. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
59. Preferential recruitment of activated, memory T-lymphocytes into skin chamber fluids during human cutaneous late phase allergic reactions
60. Adhesion molecules and their role in allergic skin diseases
61. Mechanisms of eosinophil-associated inflammation
62. Activation-independent binding of human memory T cells to ELAM-1
63. ELAM-1 is an adhesion molecule for skin-homing T cells
64. Adhesion pathways controlling recruitment responses of lymphocytes during allergic inflammatory reactions in vivo
65. Independent regulation of cutaneous lymphocyte-associated antigen expression and cytokine synthesis phenotype during human CD4+ memory T cell differentiation
66. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites
67. Induction and detection of a human endothelial activation antigen in vivo
68. Antigenspecific immune responsiveness and lymphocyte recruitment in leukocyte adhesion deficiency type II
69. Of man and mouse: Leukocyte and endothelial adhesion molecule deficiencies
70. Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis
71. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions
72. Macrophage derived chemokine (MDC) induces human eosinophil chemotaxis in a CCR3- and CCR4-independent manner
73. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
74. Cutting edge: The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
75. The surface phenotype of human eosinophils
76. Expression of a functional laminin receptor (α6β1, VLA-6) on human eosinophils
77. Chemokine receptor usage by human eosinophils - The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
78. Expression of CXCR4 in eosinophils: Functional analyses and cytokine-mediated regulation
79. Cytokine levels and inflammatory responses in developing late-phase allergic reactions in the skin
80. The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: Relationship to eosinophil, T cell, and macrophage recruitment
81. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES)
82. Chemokines in allergic cutaneous disorders
83. Adhesion molecule expression on skin endothelia in atopic dermatitis: Effects of TNFα and IL-4
84. Roles of T(H)1 and T(H)2 cytokines in a murine model of allergic dermatitis
85. Evidence for increased expression of eotaxin and MCP-4 in atopic dermatitis
86. Cutaneous injection of RANTES causes eosinophil recruitment: Comparison of nonallergic and allergic human subjects
87. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
88. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils
89. Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3
90. Interleukin-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: Association with expression of VCAM-1
91. Interleukin-13 selectively induces vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells
92. Eosinophil tethering to interleukin-4-activated endothelial cells requires both P-selectin and vascular cell adhesion molecule-1
93. Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow
94. IL-4 induces eotaxin: A possible mechanism of selective eosinophil recruitment in helminth infection and atopy
95. Lectin-like cell adhesion molecule-1 mediates leukocyte rolling in mesenteric venules in vivo
96. Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined
97. The role of adhesion molecules in the gastrointestinal tract
98. The severe and moderate phenotypes of heritable Mac-1, LFA-1, p150,95 deficiency: Their quantitative definition and relation to leukocyte dysfunction and clinical features
99. Selective expression of integrin α4β7 on a subset of human CD4(+) memory T-cells with hallmarks of gut-trophism
100. α4β7 Integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
101. Pathways of cell recruitment to mucosal surfaces
102. Critical role for β7 integrins in formation of the gut-associated lymphoid tissue
103. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin
104. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice
105. Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes
106. Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system
107. TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development
108. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9
109. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
110. Cutting edge: Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK
111. Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation
112. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice
113. Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
114. Eosinophil chemokines
115. Eotaxin is required for the baseline level of tissue eosinophils
116. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract
117. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
118. Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the mucosa of the small intestine in infants with cow's milk-sensitive enteropathy
119. Structure and function of bronchus-associated lymphoid tissue (BALT)
120. Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans?
121. Lymphocytes in the lung: Should we continue to exalt only BALT?
122. Bronchus associated lymphoid tissue (BALT) in human lung: Its distribution in smokers and non-smokers
123. Targeting VLA-4 integrin function: Potential therapeutic implications
124. Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep
125. Expression of cell adhesion molecules in asthma
126. CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein
127. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2-deficient mice results in extended hyperresponsiveness
128. Peptide and peptidomimetic inhibitors of VLA-4
129. New directions in allergic diseases: Mechanism-based anti-inflammatory therapies
130. Comparison of T lymphocyte profiles in blood and bronchoalveolar lavage after local allergen challenge
131. Expression of integrins and activation markers on blood and lung T-lymphocytes in allergic asthmatics and allergic rhinitics
132. Lung epithelial lining fluid T cell subsets defined by distinct patterns of β7 and β1 integrin expression
133. Intraepithelial T-lymphocyte subsets in the airways of normal subjects and of patients with chronic bronchitis
134. Human bronchial intraepithelial T lymphocytes as a distinct T-cell subset: Their long-term survival in SCID-Hu chimeras
135. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
136. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma
137. Expression of interleukin-16 by human epithelial cells
138. Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma
139. Interleukin-16
140. Chemokines in allergic asthma
141. Cellular sources of chemokines in allergic diseases
142. Chemokines and asthma: Redundancy of function or a coordinated effort?
143. Expression of the chemokine RANTES by a human bronchial epithelial cell line: Modulation by cytokines and glucocorticoids
144. Production of the novel C-C-chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines
145. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide
146. Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells
147. The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells
148. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness
149. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation
150. Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1α in the inflammatory component of allergic airway disease
151. Lymph node trafficking and antigen presentation by endobronchial eosinophils