Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly → Pro mutation

Journal of Biological Chemistry

Volumn 274, Issue 40, 1999, Pages 28142-28149

  Chuang, Yung Jen ^a   Gettins, Peter G W ^b   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; GLYCINE; HEPARIN; PROTEINASE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTITHROMBINS; BASE SEQUENCE; CELL LINE; CRICETINAE; DNA PRIMERS; GLYCINE; HEPARIN; KINETICS; PROLINE; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SODIUM DODECYL SULFATE; SUBSTRATE SPECIFICITY;

EID: 0033215185     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.40.28142     Document Type: Article

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