Role of CD19 Tyrosine 391 in Synergistic Activation of B Lymphocytes by Coligation of CD19 and Membrane Ig

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5649-5657

  Li, Xiaoli ^b   Sandoval, David ^b   Freeberg, Larry ^b   Carter, Robert H ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; TYROSINE;

ANIMAL; ARTICLE; B LYMPHOCYTE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; RABBIT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD19; B-LYMPHOCYTES; IMMUNOGLOBULIN M; LYMPHOCYTE ACTIVATION; MICE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RABBITS; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TYROSINE;

EID: 0031570447     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Rickert, R. C., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376: 352.
2. Engel, P., L.-J. Zhou, D. C. Ord, S. Sato, B. Koller, and T. F. Tedder. 1995. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39.
3. Ahearn, J., M. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, T. Rothstein, and M. Carroll. 1996. Disruption of the CR2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4:251.
4. Croix, D., J. Ahearn, A. Rosengard, S. Han, G. Kelsoe, M. Ma, and M. Carroll. 1996. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J. Exp. Med. 183:1857.
5. Molina, H., V. Holers, B. Li, Y.-F. Fang, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R. Karr, and D. Chaplin. 1996. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc. Natl. Acad. Sci. USA 93:3357.
6. Krop, I., A. R. de Fougerolles, R. R. Hardy, M. Allison, M. S. Schlissel, and D. T. Fearon. 1996. Self-renewal of B-1 lymphocytes is dependent on CD19. Eur. J. Immunol. 26:238.
7. Heyman, B., E. J. Wiersma, and T. Kinoshita. 1990. In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody. J. Exp. Med. 172:665.
8. Hebell, T., J. M. Ahearn, and D. T. Fearon. 1991. Suppression of the immune response by a soluble complement receptor of B lymphocytes. Science 254:102.
9. Carter, R. H., M. O. Spycher, Y. C. Ng, R. Hoffman, and D. T. Fearon. 1988. Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes. J. Immunol. 141:457.
10. Carter, R. H., D. A. Tuveson, D. J. Park, S. G. Rhee, and D. T. Fearon. 1991. The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J. Immunol. 147:3663.
11. Carter, R. H., and D. T. Fearon. 1992. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256:105.
12. Dempsey, P. W., M. E. Allison, S. Akkaraju, C. C. Goodnow, and D. T. Fearon. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348.
13. Tedder, T. F. 1994. The CD19/CD21 signal transduction complex of B lymphocytes. Immunol. Today 15:437.
14. Fearon, D. T., and R. H. Carter. 1995. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu. Rev. Immunol. 13:127.
15. Tuveson, D. A., R. H. Carter, S. P. Soltoff, and D. T. Fearon. 1993. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260:986.
16. Weng, W.-K., L. Jarvis, and T. W LeBien. 1994. Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J. Biol. Chem. 269:32514.
17. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, B. G. Neel, R. B. Birge, J. E. Farado, M. M. Chou, H. Hanafusa, B. Schaffhausen, and L. C. Cantley. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767.
18. Chalupny, N. J., A. Aruffo, J. M. Esselstyn, P. Y. Chan, J. Bajorath, J. Blake, L. K. Gilliland, J. A. Ledbetter, and M. A. Tepper. 1995. Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains. Eur. J. Immunol. 25:2978.
19. Matsumoto, A. K., D. R. Martin, R. H. Carter, L. B. Klickstein, J. Ahearn, and D. T. Fearon. 1993. Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. J. Exp. Med. 178:1407.
20. Alessi, D., A. Cuenda, P. Cohen, D. Dudley, and A. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
21. Carter, R., G. Doody, J. Bolen, and D. Fearon. 1997. Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex. J. Immunol. 158:3062.
22. Alvarez, E., I. C. Northwood, F. A. Gonzaler, D. A. Latour, A. Seth, C. Abate, T. Curran, and R. J. Davis. 1991. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation: characterization of the phosphorylation of c-Myc and c-Jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 266:15277.
23. Pulverer, B. J., J. M. Kyriakis, J. Avruch, E. Nikolakaki, and J. R. Woodgett. 1991. Phosphorylation of c-jun mediated by MAP kinases. Nature 353:670.
24. Gille, H., A. D. Sharrocks, and P. E. Shaw. 1992. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414.
25. Gold, M. R., J. S. Sanghera, J. Stewart, and S. L. Pelech. 1992. Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking: evidence for protein kinase C-independent and -dependent mechanisms of activation. Biochem. J. 287: 269.
26. Tordai, A., R. A. Franklin, H. Patel, A. M. Gardner, G. L. Johnson, and E. W. Gelfand. 1994. Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/ MAPK cascade in human B lymphocytes. J. Biol. Chem. 269:7538.
27. ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes. J. Exp. Med. 181:417.
28. Crespo, P., K. Schuebel, A. Ostrom, J. Gutkind, and X. Bustelo. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the Vav protooncogene product. Nature 385:169.
29. Ye, Z. S., and D. Baltimore. 1991. Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc. Natl. Acad. Sci. USA 26:12629.
30. Hanazono, Y., K. Sasaki, H. Odai, T. Mimura, K. Mitani, Y. Yazaki, and H. Hirai. 1995. Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7. Jpn. J. Cancer Res. 86:336.
31. Gulbins, E., K. M. Coggeshall, O. Baier, S. Katzav, P. Burn, and A. Altman. 1993. Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 260:822.
32. Gulbins, E., C. Langlet. G. Baier. N. Bonnefoy-Berard, E. Herbert, A. Altman, and K. Coggeshall. 1994. Tyrosine phosphorylation and activation of Vav GTP/ GDP exchange activity in antigen receptor-triggered B cells. J. Immunol. 152: 2123.
33. Gulbins, E., K. Coggeshall, C. Langlet, G. Baier, N. Bonnefoy-Berard, P. Burn, A. Wittinghofer, S. Katzav, and A. Altman. 1994. Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol. Cell. Biol. 14:906.
34. Bustelo, X. R., K. Suen, K. Leftheris, C. A. Meyers, and M. Barbacid. 1994. Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor. Oncogene 9:2405.
35. Khosravi-Far, R., M. Chrzanowska-Wodnicka, P. A. Solski, A. Eva, K. Burridge, and C. J. Der. 1994. Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol. Cell. Biol. 14:6848.
36. vav activity. Mol. Cell. Biol. 15:4337.
37. Coso, O. A., M. Chiarielio, J. C. Yu, H. Teramoto, P. Crespo, N. Xu, and T. Miki. 1995. The small GTP-hinding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137.
38. Minden, A., A. Lin, F. X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147.
39. Crespo, P., X. R. Bustelo, D. S. Aaronson, O. A. Coso, M. Lopez-Barahona, M. Barbacid, and J. S. Gutkind. 1996. Rac-1 dependent stimulation of the JNK/ SAPK signaling pathway by Vav. Oncogene 13:455.
40. Vojtek, A. B., and J. A. Cooper. 1995. Rho family members: activators of MAP kinase cascades. Cell 82:527.
41. Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315.
42. Gardner, A. M., R. R. Vaillancourt, C. A. Lange-Carter, and G. L. Johnson. 1994. MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity. Mol. Biol. Cell 5:193.
43. Yan, M., and D. J. Templeton. 1994. Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase. J. Biol. Chem. 269:19067.
44. Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266:1719.
45. Frost, J. A., S. Xu, M. R. Hutchison, S. Marcus, and M. H. Cobb. 1996. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol. Cell. Biol. 16:3707.
46. Yan, M., T. Dai, J. C. Deak, J. M. Kyriakis, L. I. Zon, J. R. Woodgett, and D. J. Templeton. 1994. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798.
47. Winston, B., C. Lange-Carter, A. Gardner, G. Johnson, and D. W. Riches. 1995. Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc. Natl. Acad. Sci. USA 92:1614.
48. Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and V. L. J. Tybulewicz. 1995. Defective antigen-receptor mediated proliferation of B and T cells in the absence of Vav. Nature 374:467.
49. Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, and W. Swat. 1995. Defective signalling through the T-and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470.
50. + thymocytes. Nature 374:474.