FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH

Molecular Cell

Volumn 5, Issue 6, 2000, Pages 1067-1072

  Wada, Tadashi ^a   Orphanides, George ^c   Hasegawa, Jun ^a   Kim, Dong Ki ^a   Shima, Daisuke ^a   Yamaguchi, Yuki ^a   Fukuda, Aya ^b   Hisatake, Koji ^b   Oh, Sangtaek ^c   Reinberg, Danny ^c   Handa, Hiroshi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ELONGATION FACTOR; RNA POLYMERASE II; TRANSCRIPTION FACTOR;

ARTICLE; CHROMATIN; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; HUMAN; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION;

EID: 0033638442     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80272-5     Document Type: Article

References (24)

1. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain
2. Reversible phosphorylation of the C-terminal domain of RNA polymerase II
3. Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae
4. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae
5. Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines
6. Activating phosphorylation of the Kin28 subunit of yeast TFIIH by Cak1p
7. Immunoaffinity purification of the human multisubunit transcription factor IIH
8. Purification of human RNA polymerase II and general transcription factors
9. Control of formation of two distinct classes of RNA polymerase II elongation complexes
10. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase
11. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
12. 5'-capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
13. The general transcription factors of RNA polymerase II
14. FACT, a factor that facilitates transcript elongation through nucleosomes
15. The chromatin-specific transcription elongation fector FACT comprises human SPT16 and SSRP1 proteins
16. Identification of multiple cyclin subunits of human P-TEFb
17. The role of general initiation factors in transcription by RNA polymerase II
18. Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process
19. Basic mechanisms of transcript elongation and its regulation
20. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs
21. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro
22. Structure and function of the human transcription elongation factor DSIF
23. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation
24. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II