Novel Hydrazino-Carbonyl-Amino-Methylated polystyrene (HCAM) resin methodology for the synthesis of P1-aldehyde protease inhibitor candidates

Organic Letters

Volumn 2, Issue 1, 2000, Pages 19-22

  Siev, Daniel V ^a   Semple, J Edward ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; PEPTIDE; POLYSTYRENE DERIVATIVE; PROTEINASE INHIBITOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; SYNTHESIS;

ALDEHYDES; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR STRUCTURE; PEPTIDES; POLYSTYRENES; PROTEASE INHIBITORS;

EID: 0033657140     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol991161e     Document Type: Article

References (44)

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44. 2O (9/1) (1.5 mL) was added to the elaborated resin (100 mg) in a Whatman minicolumn. The mixture was allowed to shake for 1 h at ambient temperature. The filtrate was collected and adjusted to pH = 3 with 6 M ammonium acetate (∼1.5 mL), and the resulting solution was purified through a miniprep RP-HPLC column. The combined fractions were lyophilized to afford the desired targets 3a-h as colorless, amorphous solids, which were stored at 0-4°C under a nitrogen atmosphere.