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Volumn 9, Issue 17, 1999, Pages 2573-2578

Novel benzo-fused lactam scaffolds as factor Xa inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; LACTAM DERIVATIVE;

EID: 0033530141     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00417-5     Document Type: Article
Times cited : (30)

References (27)
  • 6
    • 0013481920 scopus 로고    scopus 로고
    • Bristol, J. A.; Ed.; Academic: San Diego
    • (d) Ripka, W. C.; Vlasuk, G. P. Ann. Rep. Med. Chem. Bristol, J. A.; Ed.; Academic: San Diego, 1997; Vol. 32, p 71.
    • (1997) Ann. Rep. Med. Chem. , vol.32 , pp. 71
    • Ripka, W.C.1    Vlasuk, G.P.2
  • 13
    • 0009713328 scopus 로고
    • PCT Patent Application WO 94/13693, 1994
    • Brunck, T. K.; Webb, T. R.; Ripka, W. C. PCT Patent Application WO 94/13693, 1994; Chem. Abstr. 1995, 122, 133851.
    • (1995) Chem. Abstr. , vol.122 , pp. 133851
    • Brunck, T.K.1    Webb, T.R.2    Ripka, W.C.3
  • 14
    • 85069417098 scopus 로고    scopus 로고
    • note
    • 1H NMR, HPLC, TLC) materials.
  • 15
    • 85069416838 scopus 로고    scopus 로고
    • note
    • Purchased from Neosystem Laboratoire, Strasbourg, France.
  • 19
    • 85069414920 scopus 로고    scopus 로고
    • note
    • The kinetic racemization/resolution protocols of ref. 9 were followed in the preparation of multigram quantities of 16b.
  • 21
    • 85069408616 scopus 로고    scopus 로고
    • note
    • (b) The yield for the preparation of the 3-nitroquinolone was increased to 28% by heating the reaction mixture for an extended period of 3 days.
  • 22
    • 85069415891 scopus 로고    scopus 로고
    • note
    • Compounds 8 and 9 were prepared using the general procedure of Scheme 2, substituting the appropriate sulfonyl chloride for α-toluenesulfonyl chloride in the conversion of 17b to 18b.
  • 24
    • 85069408923 scopus 로고    scopus 로고
    • note
    • Structural information from the X-ray crystal structure of lactam CVS 1578 bound in the active site of thrombin was utilized in modeling 5 and 6. See refs 4a and 4b.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.