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14
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85069417098
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note
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1H NMR, HPLC, TLC) materials.
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15
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85069416838
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note
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Purchased from Neosystem Laboratoire, Strasbourg, France.
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16
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0000791912
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(a) Tamura, S. Y.; Semple, J. E.; Ardecky, R. A.; Leon, P.; Carpenter, S.; Ge, Y.; Shamblin, B. M.; Weinhouse, M. I.; Ripka, W. C.; Nutt, R. F. Tetrahedron Lett. 1996, 37, 4091.
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Ge, Y.6
Shamblin, B.M.7
Weinhouse, M.I.8
Ripka, W.C.9
Nutt, R.F.10
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17
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85069404335
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PCT Intl. Appl. WO 92/16524
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Fisher, M. H.; Wyvratt, M. J.; Shoen, W. R.; Devita, R. J. PCT Intl. Appl. WO 92/16524. Chem. Abstr. 1993, 118, 169109.
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18
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85060801081
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Volante, R.P.8
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19
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85069414920
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note
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The kinetic racemization/resolution protocols of ref. 9 were followed in the preparation of multigram quantities of 16b.
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20
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0026489556
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(a) Saari, W. S.; Wai, J. S.; Fisher, T. E.; Thomas, C. M.; Hoffman, J. M.; Rooney, C. S.; Smith, A. M.; Jones, J. H.; Bamberger, D. L.; Goldman, M. E.; O'Brien, J. A.; Nunberg, J. H.; Quintero, J. C.; Schleif, W. A.; Emini, E. A.; Anderson, P. S. J. Med. Chem. 1992, 35, 3792.
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Rooney, C.S.6
Smith, A.M.7
Jones, J.H.8
Bamberger, D.L.9
Goldman, M.E.10
O'Brien, J.A.11
Nunberg, J.H.12
Quintero, J.C.13
Schleif, W.A.14
Emini, E.A.15
Anderson, P.S.16
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21
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85069408616
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note
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(b) The yield for the preparation of the 3-nitroquinolone was increased to 28% by heating the reaction mixture for an extended period of 3 days.
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22
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85069415891
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note
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Compounds 8 and 9 were prepared using the general procedure of Scheme 2, substituting the appropriate sulfonyl chloride for α-toluenesulfonyl chloride in the conversion of 17b to 18b.
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24
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85069408923
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note
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Structural information from the X-ray crystal structure of lactam CVS 1578 bound in the active site of thrombin was utilized in modeling 5 and 6. See refs 4a and 4b.
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25
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0023924910
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Mann, K. G.; Jenny, R. J.; Krishnaswamy, S. Annu. Rev. Biochem. 1988, 57, 915.
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0029014045
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Hotez, P.J.5
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