Investigation of the S3 site of thrombin: Design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1- argininals

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 6, 1999, Pages 895-900

  Reiner, John E ^a   Lim Wilby, Margeurita S ^a   Brunck, Terence K ^a   Ha Uong, Theresa ^a   Goldman, Erick A ^a   Abelman, Matthew A ^a   Nutt, Ruth F ^a   Semple, J Edward ^a   Tamura, Susan Y ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDONE DERIVATIVE; THROMBIN INHIBITOR; ARGININE; BLOOD CLOTTING FACTOR 10A; PLASMIN; THROMBIN; TRYPSIN;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; IC 50; KINETICS; SYNTHESIS;

ARGININE; FACTOR XA; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; PLASMIN; PYRIDONES; THROMBIN; TRYPSIN;

EID: 0033593971     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00102-X     Document Type: Article

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24. Compounds 3e-g were prepared using the same general procedure of Schemes 1 and 3, substituting the relevant sulfonyl chloride or sulfamoyl chloride for methanesulfonyl chloride in the reaction of 5a.