Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: Synthesis of potent, selective P3-lactam thrombin inhibitors containing P4- o-alkoxycarbonylbenzylsulfonamide residues

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 24, 1998, Pages 3683-3688

  Owens, Timothy D ^a,b   Semple, J Edward ^a  

^a Dendreon   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTAM DERIVATIVE; OXIDE; PLASMIN; PRODRUG; SACCHARIN DERIVATIVE; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION;

ANTITHROMBINS; CATALYSIS; DRUG DESIGN; MOLECULAR STRUCTURE; OXIDES; SACCHARIN; SULFONAMIDES;

EID: 0032534884     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00667-2     Document Type: Article

References (35)

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