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Volumn 9, Issue 6, 2000, Pages 24-31

The therapeutic time window-theoretical and practical considerations

Author keywords

Clinical trials; Clomethiazole; Neuroprotectants; Stroke

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; APTIGANEL; BASIC FIBROBLAST GROWTH FACTOR; CASPASE; CASPASE INHIBITOR; CITICOLINE; CLOMETHIAZOLE; EBSELEN; ELIPRODIL; FLUNARIZINE; FOSPHENYTOIN SODIUM; GANGLIOSIDE GM1; GAVESTINEL; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; LUBELUZOLE; MAGNESIUM; NALMEFENE; NEUROPROTECTIVE AGENT; NIMODIPINE; PIRACETAM; TIRILAZAD;

EID: 0033653705     PISSN: 10523057     EISSN: None     Source Type: Journal    
DOI: 10.1053/jscd.2000.19318     Document Type: Review
Times cited : (16)

References (81)
  • 2
    • 0026070207 scopus 로고
    • Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil
    • (1991) Neurosci Lett , vol.131 , pp. 171-174
    • Mitani, A.1    Andou, Y.2    Masuda, S.3
  • 3
    • 0025913062 scopus 로고
    • Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia
    • (1991) Stroke , vol.22 , pp. 1032-1039
    • Kaplan, B.1    Brint, S.2    Tanabe, J.3
  • 4
    • 0027519254 scopus 로고
    • Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats
    • (1993) Stroke , vol.24 , pp. 117-121
    • Lin, T.N.1    He, Y.Y.2    Wu, G.3
  • 5
    • 0029844856 scopus 로고    scopus 로고
    • Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug: Evidence for chronic encephalopathic processes following ischemia
    • (1996) Stroke , vol.27 , pp. 1578-1585
    • Coimbra, C.1    Drake, M.2    Boris-Moller, F.3
  • 9
    • 0030907037 scopus 로고    scopus 로고
    • Histopathologic clues to the pathways of neuronal death following ischemia/hypoxia
    • (1997) J Neurotrauma , vol.14 , pp. 313-326
    • Rosenblum, W.I.1
  • 11
    • 0031895572 scopus 로고    scopus 로고
    • Factors determining the therapeutic window for stroke
    • (1998) Neurology , vol.50 , pp. 599-603
    • Zivin, J.A.1
  • 16
    • 0030739272 scopus 로고    scopus 로고
    • The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat
    • (1997) Exp Neurol , vol.145 , pp. 425-433
    • Bordi, F.1    Pietra, C.2    Ziviani, L.3
  • 27
    • 4243318598 scopus 로고
    • Growth factors and brain injury
    • Moody TW, ed. Growth factors, peptides and receptors. New York: Plenum Press
    • (1993) , pp. 137-143
    • Berlove, D.J.1    Finklestein, S.P.2
  • 28
    • 0000002641 scopus 로고    scopus 로고
    • Neurotrophic factors
    • Hsu CY, ed. Ischemic stroke: From basic mechanisms to new drug development. Switzerland: Karger
    • (1998) , pp. 116-126
    • Chen, K.1    Finklestein, S.P.2
  • 32
    • 0029888311 scopus 로고    scopus 로고
    • Role of oxidants in ischemic brain damage
    • (1996) Stroke , vol.27 , pp. 1124-1129
    • Chan, P.H.1
  • 43
    • 0033565587 scopus 로고    scopus 로고
    • Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat
    • (1999) J Neurosci , vol.19 , pp. 5932-5941
    • Velier, J.J.1    Ellison, J.A.2    Kikly, K.K.3
  • 46
    • 0033557658 scopus 로고    scopus 로고
    • Suppression of postischemic hippocampal nerve growth factor expression by a c-fos antisense oligodeoxynucleotide
    • (1999) J Neurosci , vol.19 , pp. 1335-1344
    • Cui, J.K.1    Hsu, C.Y.2    Liu, P.K.3
  • 48
    • 0025344617 scopus 로고
    • A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury: Results of the Second National Acute Spinal Cord Injury Study
    • (1990) N Engl J Med , vol.322 , pp. 1405-1411
    • Bracken, M.B.1    Shepard, M.J.2    Collins, W.F.3
  • 49
    • 0027377378 scopus 로고
    • Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NAS-CIS 2
    • (1993) J Neurosurg , vol.79 , pp. 500-507
    • Bracken, M.B.1    Holford, T.R.2
  • 51
    • 0028921447 scopus 로고
    • Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke: Results of a phase IIa randomized trial
    • (1995) Stroke , vol.26 , pp. 602-605
    • Grotta, J.1    Clark, W.2    Coull, B.3
  • 57
    • 0031981370 scopus 로고    scopus 로고
    • Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI
    • (1998) Stroke , vol.29 , pp. 939-943
    • Rordorf, G.1    Koroshetz, W.J.2    Copen, W.A.3
  • 59
    • 0000199609 scopus 로고    scopus 로고
    • New magnetic resonance imaging techniques for stroke diagnosis and treatment
    • Hsu CY, ed. Ischemic stroke: From basic mechanisms to new drug development. Switzerland: Karger
    • (1998) , pp. 139-150
    • Fisher, M.1    Warach, S.2
  • 61
    • 0006859222 scopus 로고    scopus 로고
    • Cervene in acute ischemic stroke: Results of a double-blinded, placebo-controlled, dose-comparison study
    • abstr
    • (1999) Stroke , vol.30 , pp. 2774
    • Clark, W.1
  • 68
  • 69
    • 0028450967 scopus 로고
    • Ganglioside GM1 in acute ischemic stroke: The SASS Trial
    • (1994) Stroke , vol.25 , pp. 1141-1148
  • 71
    • 0343415042 scopus 로고    scopus 로고
    • Phase II studies of the glycine antagonist GV150526 in acute stroke: The North American experience
    • The North American Glycine Antagonist in Neuroprotection (GAIN) Investigators
    • (2000) Stroke , vol.31 , pp. 358-365
  • 72
    • 0034600485 scopus 로고    scopus 로고
    • Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: A randomised controlled trial
    • (2000) Lancet , vol.355 , pp. 1949-1954
    • Lees, K.R.1    Asplund, K.2    Carolei, A.3
  • 73
    • 0030069170 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke: A double-blind, placebo-controlled phase II trial
    • Lubeluzole International Study Group
    • (1996) Stroke , vol.27 , pp. 76-81
    • Diener, H.C.1    Hacke, W.2    Hennerici, M.3
  • 74
    • 0031438509 scopus 로고    scopus 로고
    • Lubeluzole treatment of acute ischemic stroke: The US and Canadian Lubeluzole Ischemic Stroke Study Group
    • (1997) Stroke , vol.28 , pp. 2338-2346
    • Grotta, J.1
  • 76
    • 0025114628 scopus 로고
    • Randomised, double-blind, placebo-controlled trial of nimodipine in acute stroke
    • Trust Study Group
    • (1990) Lancet , vol.336 , pp. 1205-1209
  • 77
    • 0026544260 scopus 로고
    • Clinical trial of nimodipine in acute ischemic stroke
    • The American Nimodipine Study Group [published erratum appears in Stroke 1992 Apr;23(4):615]
    • (1992) Stroke , vol.23 , pp. 3-8
  • 80
    • 0031781078 scopus 로고    scopus 로고
    • High-dose tirilazad for acute stroke (RANTTAS II)
    • RANTTAS II Investigators [letter; comment]
    • (1998) Stroke , vol.29 , pp. 1256-1257
    • Haley, E.C.1
  • 81
    • 0043204506 scopus 로고    scopus 로고
    • A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS)
    • The RANTTAS Investigators
    • (1996) Stroke , vol.27 , pp. 1453-1458


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.