Gene targeting of chemokines and their receptors

Springer Seminars in Immunopathology

Volumn 22, Issue 4, 2000, Pages 417-432

  Slattery, D M ^a   Gerard, N ^a   Gerard, C ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; EOTAXIN; EPSTEIN BARR VIRUS INDUCED MOLECULE 1 LIGAND CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; DEVELOPMENTAL GENETICS; GENE MAPPING; GENE TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; NEUROBIOLOGY; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; REVIEW; TH1 CELL; TH2 CELL;

EID: 0033636928     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002810000055     Document Type: Review

References (59)

1. + lymphocyte associated Th2-type immune response in the intestine
2. Interleukin-8 and its receptor CXCR2 in atherosclerosis
3. Impaired monocyte migration and reduced type 1 (Th 1) cytokine responses in CC chemokine receptor 2 knock out mice
4. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
5. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1
6. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homologue
7. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock
8. Requirement of MIP-1 alpha for an inflammatory response to viral infection
9. CCR6 mediates dendritic cell localization, lymphocyte homeostasis and immune responses in mucosal tissue
10. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus
11. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E deficient mice
12. A putative chemokine receptor. BLR1 directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
13. CCR7 coordinates the primary immune response by establishing functional movement in secondary lymphoid organs
14. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1
15. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1 - Type 2 cytokine balance in mice lacking CC chemokine receptor 1
16. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic allograft rejection
17. Targeted disruption of the B chemokine receptor CCR 1 protects against pancreatitis-associated lung injury
18. MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B
19. Transgenic monocyte chemoattractaut protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: Abrogation by a second transgene expressing systemic MCP-1
20. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
21. Monocyte chemottractant protein-I is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation
22. A B-cell homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
23. Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2
24. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
25. The T cell directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
26. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4
27. Myocarditis induced by targeted expression of the MCP-l gene in murine cardiac muscle
28. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
29. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
30. B cell attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
31. Transgenic methods to study chemokine function in lung and central nervous system
32. Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells
33. Control of Th2 polarization by the chemokine monocyte chemoattractant protein-1
34. Abnormalities in monocyte recruitment and Cytokine expression in monocyte chemoattractant protein1 deficient mice
35. Delayed wound healing and disorganised neovascularisation in transgenic mice expressing the IP-10 chemokine
36. Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4 and SDF-I-deficient mice
37. CXC chemokine receptor-2 ligands are necessary components of neutrophil mediated host defense in invasive pulmonary aspergillosis
38. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract
39. Bacterial clearance and survival are dependent on CXC chemokine receptor-2 ligands in a murine model of pulmonary Nocardia asteroides
40. Defects of B cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
41. Molecular cloning of a novel human CC chemokine secondary lymphoid tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13
42. Keratinocyte derived monocyte chemoattractant protein-1 (MCP-1): Analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and langerhans cells to skin
43. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophils
44. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens
45. Defects in the generation of IFN-gamma are overcome to control infection with Leishmanita donovani in CC chemokine receptor (CCR) 5-macrophage inflammatory protein-1 alpha-, or CCR2deficient mice
46. Insertion of DNA sequences into the human chromosomal B-globulin locus by homologous recombination
47. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
48. Neutrophil infiltration, glial reaction and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes
49. Lack of chemokine receptor CCRI enhances Th1 responses and glomerular injury during nephrotic nephritis
50. Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1 alpha or its CCR5 receptor
51. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia
52. Lung specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice
53. CXCR5 deficient mice develop functional germinal centers in the splenic T cell zone
54. Antigen induced eosinophilic lung inflammation deVelOps in mice deficient in chemokine eotaxin
55. Molecular cloning of a novel CC chemokine EBII ligand chemokine that is a specific functional ligand for EBII, CCR7
56. Secondary lymphoid tissue chemokine is a functional ligand for the CC chemokine receptor CCR7
57. Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR 1
58. Impaired macrophage function and enhanced T cell dependent immune reponse in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor
59. Function of the chemokine recep-tor CXCR4 in haematopoiesis and in cerebellar development