Activation of pancreatic acinar cells on isolation from tissue: Cytokine upregulation via p38 MAP kinase

American Journal of Physiology - Cell Physiology

Volumn 279, Issue 6 48-6, 2000, Pages

  Blinman, Thane A ^a   Gukovsky, Ilya ^a   Mouria, Michelle ^a   Zaninovic, Vjekoslav ^a   Livingston, Edward ^a   Pandol, Stephen J ^a   Gukovskaya, Anna S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Chemokines; Interleukin 6; Monocyte chemotactic protein 1; Nuclear factor B; Pancreatitis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR;

ACINAR CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREATITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033635372     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.279.6.c1993     Document Type: Article

References (43)

1. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
2. Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis
3. Signals and receptors involved in recruitment of inflammatory cells
4. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-β p 65 transactivation mediated by tumor necrosis factor
5. A new, rapid method for preparation of dispersed pancreatic acini
6. Both Erk and p38 kinases are necessary for cytokine gene transcription
7. New insights into the role of nuclear factor-kappa B, a ubiquitous transcription factor in the initiation of diseases
8. Cytokine function: A study in biologic diversity
9. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin- 1
10. Pancreatic acinar cells in culture: Expression of acinar and ductal antigens in a growth-related manner
11. Bcl- 2 activates the transcription factors NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha
12. Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells
13. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
14. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis
15. Interleukine- 8 and neutrophil activation in acute pancreatitis
16. Pancreatic acinar cells produce release and respond to tumor necrosis factor alpha
17. Early NF-κB activation is associated with hormone-induced pancreatitis
18. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas
19. Cholecystokinin induction of mob-1 chemokine expression in pancreatic acinar cells requires NF-κB activation
20. Interleukin- 6 is a useful marker for early prediction of the severity of acute pancreatitis
21. Mediation by NF-κB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors
22. Isolation and culture of microvascular endothelium from human adipose tissue
23. Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1β- and tumor necrosis factor -α-induced low density lipoprotein receptor expression in HepG 2 cells
24. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
25. Isolation, culture and functional evaluation of islets of Langerhans
26. Chemokines - Chemotactic cytokines that mediate inflammation
27. Regulation of interleukin-1β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
28. Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
29. The role of cytokines in the pathogenesis of acute pancreatitis
30. Mechanism of [Tyr4] bombesin-induced desensitization in dispersed acini from guinea pig pancreas
31. Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide
32. Stress-activated protein kinases: Activation, regulation and function
33. A rapid method for the isolation of viable cardiac myocytes from adult rat
34. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis
35. A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini
36. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation
37. Critical evaluation of methods used for the isolation of rat liver hepatocytes fro metabolic studies
38. p38 MAP kinase is expressed in the pancreas and is immediately activated following cerulein hyperstimulation
39. AP-1: One switch for many signals
40. The NF-κB/ Rel and IκB gene families: Mediators of immune response and inflammation
41. Requirement of mitogen-activated protein kinase kinase 3 (MMK3) for tumor necrosis factor-induced cytokine expresssion
42. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
43. Cerulein upregulates ICAM- 1 in pancreatic acinar cells which mediates neutrophil adhesion to these cells