Desensitization of β2-adrenoceptor and hypersensitization to phosphodiesterase inhibitors elicited by β2-agonists in guinea pig eosinophils

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 5, 2000, Pages 896-903

  Mio, Mitsunobu ^a   Kirino, Yasushi ^a   Kamei, Chiaki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cyclic adenosine monophosphate; Desensitization; Eosinophil; Eosinophil peroxidase; Phosphodiesterase; Protein kinase A; 2 adrenoceptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIMYCIN; CALCIUM IONOPHORE; CLENBUTEROL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FENOTEROL; KT 5720; PEROXIDASE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SALBUTAMOL; THEOPHYLLINE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUCLADESINE; CARBAZOLE DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; EOSINOPHIL PEROXIDASE; FORSKOLIN; INDOLE DERIVATIVE; IONOPHORE; PYRROLE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; DOSE TIME EFFECT RELATION; ENZYME INHIBITOR COMPLEX; ENZYME RELEASE; EOSINOPHIL; GUINEA PIG; HYPERSENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; INTRACELLULAR FLUID; METABOLISM; TIME;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; BUCLADESINE; CALCIMYCIN; CARBAZOLES; CELLS, CULTURED; CLENBUTEROL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; EOSINOPHIL PEROXIDASE; EOSINOPHILS; FENOTEROL; FORSKOLIN; GUINEA PIGS; INDOLES; INTRACELLULAR FLUID; IONOPHORES; MALE; PEROXIDASES; PHOSPHODIESTERASE INHIBITORS; PYRROLES; RECEPTORS, ADRENERGIC, BETA-2; THEOPHYLLINE; TIME FACTORS;

EID: 0033623614     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.110099     Document Type: Article

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