Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF β-receptor

Journal of Cell Science

Volumn 111, Issue 1, 1998, Pages 111-120

  Ruusala, Aino ^a   Sundberg, Christian ^a   Arvidsson, Ann Kristin ^a   Rupp Thuresson, Eva ^a,b   Heldin, Carl Henrik ^a   Claesson Welsh, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b PFIZER INC   (United States)

Author keywords

Actin; PDGF; Ruffle; Tyrosine phosphorylation

Indexed keywords

ACTIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; TYROSINE;

ANIMAL CELL; ARTICLE; CYTOSKELETON; ENDOTHELIUM CELL; FLUORESCENCE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL;

EID: 0031975810     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Arcaro, A. and Wymann, M. P. (1993). Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296, 297-301.
2. Claesson-Welsh, L. (1994). Platelet-derived growth factor receptor signals. J. Biol. Chem. 269, 32023-32026.
3. Claesson-Welsh, L., Eriksson, A., Morén, A., Severinsson, L., Ek, B., Östman, A., Betsholtz, C. and Heldin, C.-H. (1988) cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol. Cell. Biol. 8, 3476-3486.
4. Hansen, K., Johnell, M., Siegbahn, A., Rorsman, C., Engström, U., Wernstedt, C., Heldin, C.-H. and Rönnstrand, L. (1996). Mutation of a Src phosphorylalion site in the PDGF β-rcceptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis. EMBO J. 15, 5299-5313.
5. Hawkins, P. T., Eguinoa, A., Qiu, R.-G., Stokoe, D., Cooke, F. T., Walters, R., Wennström, S., Claesson-Welsh, L., Evans, T., Symons, M. and Stephens, L. (1995). PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5, 393-403.
6. Heldin, C.-H. and Westermark, B. (1996) Role of platelet-derived growth factor in vivo. In The Molecular and Cellular Biology of Wound Repair (ed. R. A. F. Clark), pp. 249-273. Plenum Press, New York.
7. Kumjian, D. A., Wahl, M. I., Rhee, S. G. and Daniel, T. O. (1989) Platelet derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C. Proc. Nat. Acad. Sci. USA 86, 8232-8236.
8. Kundra, V., Escobedo, J. A., Kazlauskas, A., Kim, H. K., Rhee, S. G., Williams, L. T. and Zetter, B. R. (1994). Regulation of chemotaxis by the platelet-derived growth factor receptor-β. Nature 367, 474-476.
9. Lim, L., Manser, E., Leung, T. and Hall, C. (1996). Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem. 242, 171-185.
10. Nobes, C. D. and Hall, A. (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81, 53-62.
11. Panayotou, G. and Waterfield, M. D. (1992). Phosphatidyl-inositol 3-kmase: a key enzyme in diverse signalling processes. Trends Cell Biol. 2, 358-360.
12. Pawson, T. (1995). Protein modules and signalling networks. Nature 373, 573-580.
13. Reif, K., Nobes, C. D., Thomas, G., Hall, A. and Cantrell, D. A. (1996) Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6, 1445-1455.
14. Rhee, S. G., Suh, P.-G., Ryu, S.-H. and Lee, S. Y. (1989) Studies of inositol phospholipid-specific phospholipase C. Science 244, 546-550.
15. Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
16. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
17. Valgeirsdóttir, S., Paukku, K., Silvennoinen, O., Heldin, C.-H. and Claesson-Welsh, L. (1997). Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains. Oncogene (in press).
18. Wahl, M. and Carpenter, G. (1991). Selective phospholipase C activation. BioEssays 13, 107-113.
19. Wennström, S., Hawkins, P., Cooke, F., Hara, K., Yonezawa, K., Kasugi, M., Jackson, T., Claesson-Welsh, L. and Stephens, L. (1994a). Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4, 385-393.
20. Wennstrom, S., Siegbahn, A., Yokote, K., Arvidsson, A.-K., Heldin, C.-H., Mori, S. and Claesson-Welsh, L. (1994b). Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene 9, 651-660.
21. Yokote, K., Margolis, B., Heldin, C.-H. and Claesson-Welsh, L. (1996). Grb7 is a downstream signaling component of platelet-derived growth factor α- and β-receptors. J. Biol. Chem. 271, 30942-30949.