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Volumn 272, Issue 5263, 1996, Pages 830-836

Crystal structure of the yeast TFIIA/TBP/DNA complex

Author keywords

[No Author keywords available]

Indexed keywords

TATA BINDING PROTEIN; TRANSCRIPTION FACTOR;

EID: 0029930779     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5263.830     Document Type: Article
Times cited : (242)

References (52)
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    • note
    • See Fig. 1, A and B, for the identification of the elements of secondary structure of TFIIA. Elements of TBP secondary structure have been defined previously (23).
  • 25
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    • note
    • LF60 refers to residue F60 of the LSU; similarly, SK119 refers to residue K119 in the SSU. This convention will be maintained throughout this paper.
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    • note
    • If TBP is viewed perpendicular to its pseudotwofold in the familiar saddle view, the DNA will be projecting out at the viewer on one side, and into the page on the other. The face of TBP from which the upstream DMA emanates is the upstream face, and the other face is the downstream face of TBP.
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    • note
    • The TFIIBc/TBP/TFIIA/TATA quaternary complex was modeled by overlaying the structure of Arabidopsis JBP in the TFIIBc/TBP/TATA ternary complex onto the structure of yTBP in the yTBP/yTFIIA/ TATA complex and by using the resulting matrix to translate TFIIBc into the yTBP/yTFIIA/TATA complex. TFIIBc refers to the amino-terminally deleted TFIIB used in the crystal structure.
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    • note
    • We thank G. van Duyne (DPHASES), Z. Otwinowski (DENZO and SCALEPACK), G. Meinke, and S. Williams for assistance during data collection; C. Ogata for help at the X4A beamline; T. Lagrange, D. Reinberg, R. Ebright. P. Lieberman, and J. Ozer for communicating results before publication; A. Bohm, G. Ghosh, and B. De Decker for helpful discussions; and D. Nikolov and S. Burley for providing the coordinates of the TFIIBc/ATBP/TATA box complex. Supported by grants from the National Institutes of Health to P.B.S. and S.H. J.H.G. was an American Cancer Society Fellow, and S.H. is a Leukemia Society scholar.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.