[3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 14, 1998, Pages 1919-1922

  Ornstein, Paul L ^a   Arnold, M Brian ^a   Bleisch, Thomas J ^a   Wright, Rebecca A ^a   Wheeler, William J ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYPROPAN 1 YL) 3 (DIBENZOPYRAN 4 YL)PROPANOIC ACID; LY 341495 H 3; METABOTROPIC RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; AMINO ACID; AMINO ACID RECEPTOR BLOCKING AGENT; TRITIUM; XANTHENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; DRUG RECEPTOR BINDING; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; RAT; SYNTHESIS; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FOREBRAIN; METABOLISM; RADIOASSAY;

AMINO ACIDS; ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; PROSENCEPHALON; RADIOLIGAND ASSAY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; TRITIUM; XANTHENES;

EID: 0032555062     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00329-1     Document Type: Article

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12. 11. HPLC Conditions: Sorbax SB-phenyl (3 × 250 mm) column with gradient elution of acetonitrile:water:2% aqueous acetic acid (pH 4.9) from 10:80:10 to 70:20:10 over 25 minutes at 0.6 mL/min. Retention time for 5 was 19.5 min, with a radiochemical purity of ≥98%.
13. 12. Tritiation was conducted at Chemsyn Science Laboratories, Lenexa, Kansas, 66215.
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