-
1
-
-
0001189016
-
Pharmocologisches über Aspirin (Acetylsalicyl-saüre)
-
1899
-
Dreser, H. (1899) Pharmocologisches über Aspirin (Acetylsalicyl-saüre). Pfluegers Arch. Gesamte Physiol. Menschen. Tiere 76:306-318 (1899).
-
(1899)
Pfluegers Arch. Gesamte Physiol. Menschen. Tiere
, vol.76
, pp. 306-318
-
-
Dreser, H.1
-
2
-
-
0025043289
-
The mode of action of anti-inflammatory drugs
-
Vane, J. R., and Botting, R. M. The mode of action of anti-inflammatory drugs. Postgrad. Med. J. 66:S2-S17 (1991).
-
(1991)
Postgrad. Med. J.
, vol.66
-
-
Vane, J.R.1
Botting, R.M.2
-
3
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
-
Vane, J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 231:232-235 (1971).
-
(1971)
Nat. New Biol.
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
4
-
-
0028787224
-
Cyclooxygenase-2: Regulation and relevance in inflammation
-
Mitchell, J. A., S. Larkin, and T. J. Williams. Cyclooxygenase-2: regulation and relevance in inflammation. Biochem. Pharmacol. 50:1535-1542 (1995).
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 1535-1542
-
-
Mitchell, J.A.1
Larkin, S.2
Williams, T.J.3
-
5
-
-
1842408075
-
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
-
Xie, W., J. G. Chipman, D. L. Robertson, R. L. Erikson, and D. L. Simmons. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Arch. Biochem. Biophys. 300:247-252 (1991).
-
(1991)
Arch. Biochem. Biophys.
, vol.300
, pp. 247-252
-
-
Xie, W.1
Chipman, J.G.2
Robertson, D.L.3
Erikson, R.L.4
Simmons, D.L.5
-
6
-
-
0026662385
-
Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene
-
Kujubu, D. A., and H. R. Herschman. Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J. Biol. Chem. 267:7991-7994 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 7991-7994
-
-
Kujubu, D.A.1
Herschman, H.R.2
-
7
-
-
0028323295
-
Inducible isoforms of cyclo-oxygenase and nitric oxide synthase in inflammation
-
Vane, J. R., J. A. Mitchell, I. Appleton, A. Tomlinson, D. Bishop-Bailey, J. Croxtall, and D. A. Willoughby. Inducible isoforms of cyclo-oxygenase and nitric oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA 91:2046-2050 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2046-2050
-
-
Vane, J.R.1
Mitchell, J.A.2
Appleton, I.3
Tomlinson, A.4
Bishop-Bailey, D.5
Croxtall, J.6
Willoughby, D.A.7
-
8
-
-
0028116265
-
Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenan-induced pleurisy
-
Tomlinson, A., I. Appleton, A. R. Moore, D. W. Gilroy, D. Willis, J. A. Mitchell, and D. A. Willoughby. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenan-induced pleurisy. Br. J. Pharmacol. 113:693-698 (1994).
-
(1994)
Br. J. Pharmacol.
, vol.113
, pp. 693-698
-
-
Tomlinson, A.1
Appleton, I.2
Moore, A.R.3
Gilroy, D.W.4
Willis, D.5
Mitchell, J.A.6
Willoughby, D.A.7
-
9
-
-
0028322893
-
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic
-
Masferrer, J. L., B. S. Zweifel, P. T. Manning, S. D. Hauser, K. M. Leahy, W. G. Smith, P. C. Isakson, and K. Seibert. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA 91:3228-3232 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3228-3232
-
-
Masferrer, J.L.1
Zweifel, B.S.2
Manning, P.T.3
Hauser, S.D.4
Leahy, K.M.5
Smith, W.G.6
Isakson, P.C.7
Seibert, K.8
-
10
-
-
0027146692
-
Selectivity of nonsteroid anti-inflammatory drugs as inhibitors of constitutive and inducible cyclo-oxygenase
-
Mitchell, J. A., P. Akarasereenont, C. Thiemermann, R. J. Flower, and J. R. Vane. Selectivity of nonsteroid anti-inflammatory drugs as inhibitors of constitutive and inducible cyclo-oxygenase. Proc. Natl. Acad. Sci. USA 90:11693-11697 (1993).
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 11693-11697
-
-
Mitchell, J.A.1
Akarasereenont, P.2
Thiemermann, C.3
Flower, R.J.4
Vane, J.R.5
-
11
-
-
0027480087
-
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
-
Meade, E. A., W. L. Smith, and D. L. DeWitt. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268: 6610-6614 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 6610-6614
-
-
Meade, E.A.1
Smith, W.L.2
DeWitt, D.L.3
-
12
-
-
0028123502
-
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
-
O'Neill, G. P., J. A. Mancini, S. Kargman, J. Yergey, M. Y. Kwan, J. P. Falgueyret, M. Abramovitz, B. P. Kennedy, M. Ouellet, and W. Cromlish. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol. Pharmacol. 45: 245-254 (1994).
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 245-254
-
-
O'Neill, G.P.1
Mancini, J.A.2
Kargman, S.3
Yergey, J.4
Kwan, M.Y.5
Falgueyret, J.P.6
Abramovitz, M.7
Kennedy, B.P.8
Ouellet, M.9
Cromlish, W.10
-
13
-
-
0028830109
-
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
-
Gierse, J. K., S. D. Hauser, D. P. Creely, C. Koboldt, S. H. Rangwala, P. C. Isakson, and K. Seibert. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem. J. 305: 479-484 (1995).
-
(1995)
Biochem. J.
, vol.305
, pp. 479-484
-
-
Gierse, J.K.1
Hauser, S.D.2
Creely, D.P.3
Koboldt, C.4
Rangwala, S.H.5
Isakson, P.C.6
Seibert, K.7
-
14
-
-
0029033219
-
Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
-
Chan, C. C., S. Boyce, C. Rideau, A. W. Ford-Hutchinson, R. Gordon, D. Guay, R. G. Hill, C. S. Li, J. Mancini, and M. Penneton. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J. Pharmacol. Exp. Ther. 274:1531-1537 (1995).
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.274
, pp. 1531-1537
-
-
Chan, C.C.1
Boyce, S.2
Rideau, C.3
Ford-Hutchinson, A.W.4
Gordon, R.5
Guay, D.6
Hill, R.G.7
Li, C.S.8
Mancini, J.9
Penneton, M.10
-
15
-
-
0028831977
-
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms
-
Ouellet, M., and M. D. Percival. Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem. J. 306:257-251 (1995)
-
(1995)
Biochem. J.
, vol.306
, pp. 257-1251
-
-
Ouellet, M.1
Percival, M.D.2
-
16
-
-
0028167846
-
Inhibition of NF-kappa B by sodium salicylate and aspirin
-
Kopp, E., and S. Ghosh. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science (Washington D. C.) 265:956-959 (1994).
-
(1994)
Science (Washington D. C.)
, vol.265
, pp. 956-959
-
-
Kopp, E.1
Ghosh, S.2
-
17
-
-
0025248570
-
The aspirin and heme-binding sites of ovine murine prostaglandin endoperoxide synthases
-
De Witt, D. L., E. A. El-Harith, S. A., Kraemer, M. J. Andrews, E. F. Yao, R. L. Arnstrong, and W. L. Smith. The aspirin and heme-binding sites of ovine murine prostaglandin endoperoxide synthases. J. Biol. Chem. 265: 5192-5198 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 5192-5198
-
-
De Witt, D.L.1
El-Harith, E.A.2
Kraemer, S.A.3
Andrews, M.J.4
Yao, E.F.5
Arnstrong, R.L.6
Smith, W.L.7
-
18
-
-
0018904225
-
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa
-
Whittle, B. J. R., G. A. Higgs, K. E. Eakins, S. Moncada, and J. R. Vane. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature (Lond.) 248:271-273 (1980).
-
(1980)
Nature (Lond.)
, vol.248
, pp. 271-273
-
-
Whittle, B.J.R.1
Higgs, G.A.2
Eakins, K.E.3
Moncada, S.4
Vane, J.R.5
-
19
-
-
0029056992
-
The structural basis of aspirin activity inferred from the crystal structure of in activated prostaglandin H2 synthase
-
Loll, P. J., D. Picot, and R. M. Garavito. The structural basis of aspirin activity inferred from the crystal structure of in activated prostaglandin H2 synthase. Nat. Struct. Biol. 2:637-643 (1995).
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 637-643
-
-
Loll, P.J.1
Picot, D.2
Garavito, R.M.3
-
20
-
-
0027942832
-
Induction of cyclooxygenase-2 by cytokines in human pulmonary epithelial cells: Regulation by dexamethasone
-
Mitchell, J. A., M. G. Belvisi, P. Akarasereenont, R. A. Robbins, O. J. Kwon, J. Croxtall, P. J. Barnes, and J. R. Vane. Induction of cyclooxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br. J. Pharmacol. 113:1008-1014 (1994).
-
(1994)
Br. J. Pharmacol.
, vol.113
, pp. 1008-1014
-
-
Mitchell, J.A.1
Belvisi, M.G.2
Akarasereenont, P.3
Robbins, R.A.4
Kwon, O.J.5
Croxtall, J.6
Barnes, P.J.7
Vane, J.R.8
-
21
-
-
0030051916
-
Superinduction of NF-kppaB by actinomycin D and cycloheximide in epithelial cells
-
Newton, R., I. M. Adcock, and P. J. Barnes. Superinduction of NF-kppaB by actinomycin D and cycloheximide in epithelial cells. Biochem. Biophys. Res. Commun. 218:518-523 (1996).
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.218
, pp. 518-523
-
-
Newton, R.1
Adcock, I.M.2
Barnes, P.J.3
-
22
-
-
0342742310
-
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of nuclear factor kappa B
-
Osborn, L., S. Kunkel, and G. J. Nabel. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of nuclear factor kappa B. Proc. Natl. Acad. Sci. USA 86:2336-2340 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 2336-2340
-
-
Osborn, L.1
Kunkel, S.2
Nabel, G.J.3
-
24
-
-
0026034248
-
Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells
-
Wu, K. K., R. Sanduja, A. L. Tsai, B. Ferhaboglu, and D. S. Loose-Mitchell. Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc. Natl. Acad. Sci. USA 88:2384-2387 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 2384-2387
-
-
Wu, K.K.1
Sanduja, R.2
Tsai, A.L.3
Ferhaboglu, B.4
Loose-Mitchell, D.S.5
-
25
-
-
2542425151
-
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and anti-inflammatory activity
-
Higgs, G. A., J. A. Salmon, B. Henderson, and J. R. Vane. Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and anti-inflammatory activity. Proc. Natl. Acad. Sci. USA 84:1417-1420 (1987).
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 1417-1420
-
-
Higgs, G.A.1
Salmon, J.A.2
Henderson, B.3
Vane, J.R.4
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