메뉴 건너뛰기




Volumn 33, Issue 6, 1997, Pages 403-416

Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?

Author keywords

[No Author keywords available]

Indexed keywords

6 METHOXY 2 NAPHTHYLACETIC ACID; CYCLOOXYGENASE 2; NABUMETONE; NONSTEROID ANTIINFLAMMATORY AGENT; SERUM ALBUMIN; ALKANONE; PROSTAGLANDIN SYNTHASE INHIBITOR;

EID: 0031454049     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199733060-00001     Document Type: Article
Times cited : (49)

References (45)
  • 1
    • 0025325979 scopus 로고
    • The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function
    • Jeremy JY, Mikhailidis DP, Barradas MA. The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function. Br J Rheum 1990; 29: 116-9
    • (1990) Br J Rheum , vol.29 , pp. 116-119
    • Jeremy, J.Y.1    Mikhailidis, D.P.2    Barradas, M.A.3
  • 2
    • 0018248615 scopus 로고
    • 4-(6-Methoxy-2-naphthyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds
    • Goudie AC, Gaster LM, Lake AW, et al. 4-(6-Methoxy-2-naphthyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds. J Med Chem 1978; 219 (12): 1260-4
    • (1978) J Med Chem , vol.219 , Issue.12 , pp. 1260-1264
    • Goudie, A.C.1    Gaster, L.M.2    Lake, A.W.3
  • 3
    • 0023912709 scopus 로고
    • Nabumetone: A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases
    • Friedel HA, Todd PA. Nabumetone: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases. Drugs 1988; 35 (5): 504-24
    • (1988) Drugs , vol.35 , Issue.5 , pp. 504-524
    • Friedel, H.A.1    Todd, P.A.2
  • 4
    • 0027475765 scopus 로고
    • Nabumetone: A reappraisal of its pharmacology and therapeutic use in rheumatic diseases
    • Friedel HA, Langtry HD, Buckley MM. Nabumetone: a reappraisal of its pharmacology and therapeutic use in rheumatic diseases. Drugs 1993; 45 (1): 131-6
    • (1993) Drugs , vol.45 , Issue.1 , pp. 131-136
    • Friedel, H.A.1    Langtry, H.D.2    Buckley, M.M.3
  • 5
    • 0021734586 scopus 로고
    • High-performance liquid chromatographic determination of a new anti-inflammatory agent, nabumetone, and its major metabolite in plasma using fluorimetric detection
    • Ray JE, Day RO. High-performance liquid chromatographic determination of a new anti-inflammatory agent, nabumetone, and its major metabolite in plasma using fluorimetric detection. J Chromatogr 1984; 336: 234-8
    • (1984) J Chromatogr , vol.336 , pp. 234-238
    • Ray, J.E.1    Day, R.O.2
  • 6
    • 0022516471 scopus 로고
    • Liver insufficiency as a factor modifying the pharmacokinetic characteristic of the preparation nabumetone
    • Maleev A, Vlahov V, Gruev I, et al. Liver insufficiency as a factor modifying the pharmacokinetic characteristic of the preparation nabumetone. Int J Clin Pharmacol Ther Toxicol 1986; 24 (8): 425-9
    • (1986) Int J Clin Pharmacol Ther Toxicol , vol.24 , Issue.8 , pp. 425-429
    • Maleev, A.1    Vlahov, V.2    Gruev, I.3
  • 7
    • 0023471297 scopus 로고
    • Blood and tissue fluid levels of a new non- Steroidal anti-inflammatory preparation of nabumetone
    • Torre D, Sampietro C, Maggiolo F. Blood and tissue fluid levels of a new non- steroidal anti-inflammatory preparation of nabumetone. J Int Med Res 1987; 15: 368-73
    • (1987) J Int Med Res , vol.15 , pp. 368-373
    • Torre, D.1    Sampietro, C.2    Maggiolo, F.3
  • 8
    • 0023629415 scopus 로고
    • Bioequivalence study of nabumetone: Tablet versus suspension
    • Daigneault EA, Ferslew KE, Stanton P. Bioequivalence study of nabumetone: tablet versus suspension. Am J Med 1987; 83 Suppl. 4B: 11-4
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 4B , pp. 11-14
    • Daigneault, E.A.1    Ferslew, K.E.2    Stanton, P.3
  • 9
    • 0024556461 scopus 로고
    • A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients
    • Kendall MJ, Chellingsworth MC, Jubb R, et al. A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients. Eur J Clin Pharmacol 1989; 36: 299-305
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 299-305
    • Kendall, M.J.1    Chellingsworth, M.C.2    Jubb, R.3
  • 10
    • 0025642872 scopus 로고
    • Penetration of the active metabolite of nabumetone into synovial fluid and adherent tissue of patients undergoing knee joint surgery
    • Miehlke RK, Schneider S, Sorgel F, et al. Penetration of the active metabolite of nabumetone into synovial fluid and adherent tissue of patients undergoing knee joint surgery. Drugs 1990; 40 Suppl. 5: 57-61
    • (1990) Drugs , vol.40 , Issue.5 SUPPL. , pp. 57-61
    • Miehlke, R.K.1    Schneider, S.2    Sorgel, F.3
  • 11
    • 0021191813 scopus 로고
    • Metabolism of nabumetone (BRL 1477) by various species including man
    • Haddock RE, Jeffrey DJ, Llloyd JA, et al. Metabolism of nabumetone (BRL 1477) by various species including man. Xenobiotica 1984; 14(4): 327-37
    • (1984) Xenobiotica , vol.14 , Issue.4 , pp. 327-337
    • Haddock, R.E.1    Jeffrey, D.J.2    Llloyd, J.A.3
  • 12
    • 0020559687 scopus 로고
    • Nabumetone. a novel anti-inflammatory drug: The influence of food, milk, antacids, and analgesics on bioavailability of single oral doses
    • Von Schrader HW, Buscher G, Dierdorf D, et al. Nabumetone. A novel anti-inflammatory drug: the influence of food, milk, antacids, and analgesics on bioavailability of single oral doses. Int J Clin Pharmacol Ther Toxicol 1983; 21 (6): 311-21
    • (1983) Int J Clin Pharmacol Ther Toxicol , vol.21 , Issue.6 , pp. 311-321
    • Von Schrader, H.W.1    Buscher, G.2    Dierdorf, D.3
  • 13
    • 0021683274 scopus 로고
    • Nabumetone. a novel anti-inflammatory drug: Bioavailability after different dosage regimens
    • Von Schrader HW, Buscher G, Dierdorf D, et al. Nabumetone. A novel anti-inflammatory drug: bioavailability after different dosage regimens. Int J Clin Pharmacol Ther Toxicol 1984; 22 (2): 672-6
    • (1984) Int J Clin Pharmacol Ther Toxicol , vol.22 , Issue.2 , pp. 672-676
    • Von Schrader, H.W.1    Buscher, G.2    Dierdorf, D.3
  • 14
    • 0343593813 scopus 로고
    • A study of the pharmacokinetics, effectiveness, and tolerance of nabumetone, a novel anti-inflammatory drug, in elderly patients
    • Nandi KL, Corless D, Undre NA, et al. A study of the pharmacokinetics, effectiveness, and tolerance of nabumetone, a novel anti-inflammatory drug, in elderly patients. Roy Soc Med Int Sym Ser 1985; 69: 163-72
    • (1985) Roy Soc Med Int Sym Ser , vol.69 , pp. 163-172
    • Nandi, K.L.1    Corless, D.2    Undre, N.A.3
  • 15
    • 0342723861 scopus 로고
    • The pharmacokinetics of nabumetone in elderly patients
    • Hamdy RC, Price JD, Undre NA, et al. The pharmacokinetics of nabumetone in elderly patients. Roy Soc Med Int Sym Ser 1985; 69: 173-9
    • (1985) Roy Soc Med Int Sym Ser , vol.69 , pp. 173-179
    • Hamdy, R.C.1    Price, J.D.2    Undre, N.A.3
  • 16
    • 0023614928 scopus 로고
    • Nabumetone pharmacokinetics in patients with varying degrees of renal impairment
    • Boelaert JR, Jonnaert HA, Daneels RF, et al. Nabumetone pharmacokinetics in patients with varying degrees of renal impairment. Am J Med 1987; 83 Suppl. 4B: 107-9
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 4B , pp. 107-109
    • Boelaert, J.R.1    Jonnaert, H.A.2    Daneels, R.F.3
  • 17
    • 0023624632 scopus 로고
    • Nabumetone kinetics in the young and elderly
    • McMahon FG, Vargas R, Ryan JR. Nabumetone kinetics in the young and elderly. Am J Med 1987: 83 Suppl. 4B: 92-5
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 4B , pp. 92-95
    • McMahon, F.G.1    Vargas, R.2    Ryan, J.R.3
  • 18
    • 0023240105 scopus 로고
    • Nabumetone (BRL 14777) presystemic elimination and disposition in patients with liver impairments
    • Terziivanov D, Maleev A, Vlahov V. Nabumetone (BRL 14777) presystemic elimination and disposition in patients with liver impairments. Int J Clin Pharmacol Ther Toxicol 1987; 25 (4): 208-13
    • (1987) Int J Clin Pharmacol Ther Toxicol , vol.25 , Issue.4 , pp. 208-213
    • Terziivanov, D.1    Maleev, A.2    Vlahov, V.3
  • 19
    • 0342723863 scopus 로고
    • Multiple dose kinetics of nabumetone in renal impairment
    • Brier ME, Aronoff GR. Multiple dose kinetics of nabumetone in renal impairment [abstract]. Clin Res 1990; 38: 520
    • (1990) Clin Res , vol.38 , pp. 520
    • Brier, M.E.1    Aronoff, G.R.2
  • 20
    • 0025681694 scopus 로고
    • Nabumetone: Evidence for the lack of enterohepatic circulation of the active metabolite 6-MNA in humans
    • Brett MA, Buscher G, Ellrich E, et al. Nabumetone: evidence for the lack of enterohepatic circulation of the active metabolite 6-MNA in humans. Drugs 1990; 40 Suppl. 5: 67-70
    • (1990) Drugs , vol.40 , Issue.5 SUPPL. , pp. 67-70
    • Brett, M.A.1    Buscher, G.2    Ellrich, E.3
  • 21
    • 0029018597 scopus 로고
    • Population pharmacokinetics of the active metabolite of nabumetone in renal dysfunction
    • Brier ME, Sloan RS, Aronoff GR. Population pharmacokinetics of the active metabolite of nabumetone in renal dysfunction. Clin Pharmacol Ther 1995; 57: 622-7
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 622-627
    • Brier, M.E.1    Sloan, R.S.2    Aronoff, G.R.3
  • 22
    • 0026461041 scopus 로고
    • An overview of the clinical pharmacokinetics of nabumetone
    • Hyneck ML. An overview of the clinical pharmacokinetics of nabumetone. J Rheumatol 1992; 19 Suppl. 36: 20-4
    • (1992) J Rheumatol , vol.19 , Issue.36 SUPPL. , pp. 20-24
    • Hyneck, M.L.1
  • 23
    • 0030972931 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of naproxen
    • Davies NM, Anderson KE. Clinical pharmacokinetics of naproxen. Clin Pharmacokinet 1997; 32 (4): 321-5
    • (1997) Clin Pharmacokinet , vol.32 , Issue.4 , pp. 321-325
    • Davies, N.M.1    Anderson, K.E.2
  • 24
    • 6844234604 scopus 로고
    • Steady-state pharmacokinetics an ex vivo protein binding of nabumetone
    • Hyneck M, Audet P, Nichols A, et al. Steady-state pharmacokinetics an ex vivo protein binding of nabumetone. Clin Pharmacol Ther 1993; 53: 212 PIII-22
    • (1993) Clin Pharmacol Ther , vol.53
    • Hyneck, M.1    Audet, P.2    Nichols, A.3
  • 25
    • 0343593810 scopus 로고
    • An investigation into the penetration of nabumetone and its metabolites into synovial fluid in patients with rheumatoid arthritis
    • Bourke B, Undre NA, Thawley AR. An investigation into the penetration of nabumetone and its metabolites into synovial fluid in patients with rheumatoid arthritis. Roy Soc Med Int Sym Ser 1985; 69: 31-5
    • (1985) Roy Soc Med Int Sym Ser , vol.69 , pp. 31-35
    • Bourke, B.1    Undre, N.A.2    Thawley, A.R.3
  • 26
    • 0343158330 scopus 로고
    • Plasma and synovial fluid concentrations of nabumetone and BRL 10720 in patients given nabumetone
    • Freeman AM, Undre NA, Thawley AR, et al. Plasma and synovial fluid concentrations of nabumetone and BRL 10720 in patients given nabumetone. Roy Soc Med Int Sym Ser 1984; 69: 40-2
    • (1984) Roy Soc Med Int Sym Ser , vol.69 , pp. 40-42
    • Freeman, A.M.1    Undre, N.A.2    Thawley, A.R.3
  • 27
    • 0031053145 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem
    • Davies NM, Wallace JL. Non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: new insights into an old problem. J Gastroenterol 1997; 32 (2): 127-33
    • (1997) J Gastroenterol , vol.32 , Issue.2 , pp. 127-133
    • Davies, N.M.1    Wallace, J.L.2
  • 28
    • 0026001034 scopus 로고
    • The science - Equivalent efficacy and diminished risk
    • Blower P. The science - equivalent efficacy and diminished risk. Eur J Rheum Inflamm 1991; 11: 37-57
    • (1991) Eur J Rheum Inflamm , vol.11 , pp. 37-57
    • Blower, P.1
  • 29
    • 0031014088 scopus 로고    scopus 로고
    • NSAID-enteropathy in rats: Role of epithelial permeability, bacterial load, and enterohepatic circulation
    • Reuter BK, Davies NM, Wallace JL. NSAID-enteropathy in rats: role of epithelial permeability, bacterial load, and enterohepatic circulation. Gastroenterology 1997; 112 (1): 109-17
    • (1997) Gastroenterology , vol.112 , Issue.1 , pp. 109-117
    • Reuter, B.K.1    Davies, N.M.2    Wallace, J.L.3
  • 30
    • 0026019375 scopus 로고
    • Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man
    • Bjarnason I, Fehilly B, Smethurst P, et al. Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man. Gut 1991; 32: 275-7
    • (1991) Gut , vol.32 , pp. 275-277
    • Bjarnason, I.1    Fehilly, B.2    Smethurst, P.3
  • 31
    • 6844259517 scopus 로고    scopus 로고
    • High intestinal permeability in patients with inflammatory arthritis is more strongly associated with any NSAID therapy than with diagnosis or disease activity
    • Devlin J, Moots R, Andrews D, et al. High intestinal permeability in patients with inflammatory arthritis is more strongly associated with any NSAID therapy than with diagnosis or disease activity. Arthritis Rheum 1996; S280: 1513
    • (1996) Arthritis Rheum , vol.S280 , pp. 1513
    • Devlin, J.1    Moots, R.2    Andrews, D.3
  • 32
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 1971; 231: 232-5
    • (1971) Nature New Biol , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 33
    • 0021701756 scopus 로고
    • A biochemical basis for the gastrointestinal toxicity of non-steroid anti-rheumatoid drugs
    • Whittle BJR, Vane JR. A biochemical basis for the gastrointestinal toxicity of non-steroid anti-rheumatoid drugs. Arch Toxicol 1984; 7: 315-22
    • (1984) Arch Toxicol , vol.7 , pp. 315-322
    • Whittle, B.J.R.1    Vane, J.R.2
  • 34
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non- Steroidal anti-inflammatory drugs
    • Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non- steroidal anti-inflammatory drugs. J Biol Chem 1993: 268 (9): 6610-4
    • (1993) J Biol Chem , vol.268 , Issue.9 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 35
    • 0030449725 scopus 로고    scopus 로고
    • Selective inhibitors of cyclooxygenase 2: Potential in elderly patients
    • Davies NM, Wallace JL. Selective inhibitors of cyclooxygenase 2: potential in elderly patients. Drugs Aging 1996; 9 (6): 406-17
    • (1996) Drugs Aging , vol.9 , Issue.6 , pp. 406-417
    • Davies, N.M.1    Wallace, J.L.2
  • 36
    • 0031042556 scopus 로고    scopus 로고
    • Efficacy and safety of meloxicam in patients with rheumatoid arthritis
    • Lemmel EM, Bolten W, Burgos-Vargas R, et al. Efficacy and safety of meloxicam in patients with rheumatoid arthritis. J Rheumatol 1997; 24 (2): 282-90
    • (1997) J Rheumatol , vol.24 , Issue.2 , pp. 282-290
    • Lemmel, E.M.1    Bolten, W.2    Burgos-Vargas, R.3
  • 37
    • 0031016921 scopus 로고    scopus 로고
    • A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and diclofenac
    • Bjarnason I, Macpherson A, Rotman H, et al. A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and diclofenac. Scand J Gastroenterol 1997; 32 (2): 126-30
    • (1997) Scand J Gastroenterol , vol.32 , Issue.2 , pp. 126-130
    • Bjarnason, I.1    Macpherson, A.2    Rotman, H.3
  • 38
    • 0029907525 scopus 로고    scopus 로고
    • Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2
    • Reuter BK, Asfaha S, Buret A, et al. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. J Clin Invest 1996; 98: 2076-85
    • (1996) J Clin Invest , vol.98 , pp. 2076-2085
    • Reuter, B.K.1    Asfaha, S.2    Buret, A.3
  • 39
    • 0031052116 scopus 로고    scopus 로고
    • Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by specific antagonist delays healing in mice
    • Mizuno H, Sakamoto C, Matsuda K. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by specific antagonist delays healing in mice. Gastroenterology 1997; 112:387-97
    • (1997) Gastroenterology , vol.112 , pp. 387-397
    • Mizuno, H.1    Sakamoto, C.2    Matsuda, K.3
  • 40
    • 0028102673 scopus 로고
    • GI bleeding associated with nabumetone
    • Voss GD. GI bleeding associated with nabumetone. Am J Hosp Pharm 1994; 51: 2506-8
    • (1994) Am J Hosp Pharm , vol.51 , pp. 2506-2508
    • Voss, G.D.1
  • 41
    • 0027993458 scopus 로고    scopus 로고
    • Up regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhardt CE, Coffey RJ, Radhika A, et al. Up regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1996; 107: 1183-8
    • (1996) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhardt, C.E.1    Coffey, R.J.2    Radhika, A.3
  • 42
    • 0029008617 scopus 로고
    • Expression of prostaglandin G/H synthase-1 and -2 protein in human colorectal cancer
    • Kargman SL, ONeill GP, Vikers PJ, et al. Expression of prostaglandin G/H synthase-1 and -2 protein in human colorectal cancer. Cancer Res 1991; 55: 2556-9
    • (1991) Cancer Res , vol.55 , pp. 2556-2559
    • Kargman, S.L.1    Oneill, G.P.2    Vikers, P.J.3
  • 43
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimers disease
    • Rogers J, Kirby LC, Hempelman SR, et al. Clinical trial of indomethacin in Alzheimers disease. Neurology 1993; 43: 1609-11
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 44
    • 0030033449 scopus 로고    scopus 로고
    • IL-13 and IL-14 inhibit bone suppressing cyclooxygenase-2 prostaglandin synthesis in osteoblasts
    • Onoe Y, Miaura C, Kammakayashik T. IL-13 and IL-14 inhibit bone suppressing cyclooxygenase-2 prostaglandin synthesis in osteoblasts. J Immmunol 1996; 156: 758-64
    • (1996) J Immmunol , vol.156 , pp. 758-764
    • Onoe, Y.1    Miaura, C.2    Kammakayashik, T.3
  • 45
    • 0013482013 scopus 로고
    • Double-blind study to establish whether there is any interaction between nabumetone and warfarin in healthy adult male volunteers
    • Fitzgerald DE. Double-blind study to establish whether there is any interaction between nabumetone and warfarin in healthy adult male volunteers. Roy Soc Med In Cong Sym Ser 1985; 69: 47-53
    • (1985) Roy Soc Med in Cong Sym Ser , vol.69 , pp. 47-53
    • Fitzgerald, D.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.