Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors

Journal of Medicinal Chemistry

Volumn 42, Issue 10, 1999, Pages 1749-1756

  Phillips, Gary ^a   Davey, David D ^a   Eagen, Keith A ^a   Koovakkat, Sunil K ^a   Liang, Amy ^a   Ng, Howard P ^a   Pinkerton, Michael ^a   Trinh, Lan ^a   Whitlow, Marc ^a   Beatty, Alicia M ^a,b   Morrissey, Michael M ^a  

^a Discovery Research Group   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIPHENOXYPYRIDINE; BLOOD CLOTTING FACTOR 10A INHIBITOR; PYRIDINE; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; CATTLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; PHOTOCHEMISTRY; SYNTHESIS;

AMIDINES; ANIMALS; CATTLE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR XA; FIBRINOLYTIC AGENTS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN INHIBITORS;

EID: 0033587159     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980667k     Document Type: Article

References (22)

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