Ring-based analogues of pentamidine versus P. carinii pneumonia in culture

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 19, 1996, Pages 2367-2370

  Delia, Thomas J ^a   Nagarajan, A ^a   Queener, Sherry F ^b   Bartlet, Marilyn S ^c  

^a Department of Chemistry   (United States)

^b Dept of Pharmacol and Toxicology ^*  (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; COTRIMOXAZOLE; PENTAMIDINE; PENTAMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; NONHUMAN; PNEUMOCYSTIS CARINII; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0030575618     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00427-1     Document Type: Article

References (19)

1. 1. For a recent review of this activity, see Queener, S. F. J. Med. Chem. 1995, 38, 4739.
2. 2. For a recent reference, see Schauhan, P. M.; Iyer, R. N.; Guru, P. Y.; Sen, A. B. Ind. J. Exp. Biol. 1993, 31, 196.
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13. 13. The remaining chlorine in 3c was replaced by ammonia to give the corresponding amino product, 4f, in this step.
14. 14. Compound 3a was previously described; see Ashley, J. N.; Barber, H. J.; Ewins, A. J.; Newberry, G.; Self, A. D. H. J. Chem. Soc. 1942, 103.
15. 6) δ 5.9 (s, 1H, pyrimidine H5), 7.0-7.2 (m, 4H, aromatic CH), 8.0 (d, 4H, aromatic CH), 9.4-9.6 (br m, 6H, amidino NH) ppm; 13C NMR (DMSO-d6) δ 171.8, 165.7, 163.7, 157.9, 130.9, 125.1, 122.7, 82.6 ppm; ms (m/e) 347. Anal. calcd for C18H17N7O2·3HCl·2H2O (found): C, 42.46 (41.94); H, 4.75 (5.08); N, 19.26 (19.98).
16. 16. Bartlett, M. S.; Edlind, T. D.; Durkin, M. M.; Shaw, M. M.; Queener, S. F.; Smith, J. W. Antimicrob. Agents Chemother. 1992, 36, 779.
17. 17. Bartlett, M. S.; Shaw, M. M.; Navaran, P.; Smith, J. W.; Queener, S. F. Antimicrob. Agents Chemother. 1995, 39, 2436
18. 18. Queener, S. F.; Dean, R. A.; Bartlett, M. S.; Milhous, W. K.; Berman, J. D.; Ellis, W. Y.; Smith, J. W. J. Inf. Dis. 1992, 165, 377.
19. 19. Queener, S. F.; Fujioka, H.; Nishiyama, H.; Bartlett, M. S.; Smith, J. W. Antimicrob. Agents Chemother. 1991, 3 5, 377.