Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 53-62

  Maduskuie Jr , Thomas P ^a   McNamara, Kevin J ^a   Yu, Ru ^b   Knabb, Robert M ^a   Stouten, Pieter F W ^a  

^a DUPONT COMPANY   (United States)

^b Smith Kline and Beecham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; BISPHENYLAMIDINE CARBOXYLATE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR; CARBOXYLIC ACID DERIVATIVE; PROTHROMBIN; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; BINDING SITE; BLOOD CLOTTING; DRUG POTENCY; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; MOLECULAR MODEL; NONHUMAN; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

AMIDINES; ANTICOAGULANTS; BINDING SITES; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; FACTOR XA; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS;

EID: 15144344269     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970485a     Document Type: Article

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