Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras · Raf complex in the cytosol

FEBS Letters

Volumn 378, Issue 1, 1996, Pages 15-18

  Miyake, Mika ^a   Mizutani, Shin ^a   Koide, Hiroshi ^a   Kaziro, Yoshito ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Dominant negative mutant; Farnesylation; Raf; Ras

Indexed keywords

ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOCHEMISTRY; EMBRYO; ENZYME INHIBITION; GENE ACTIVATION; HUMAN; HUMAN CELL; KIDNEY CELL; MUTANT; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

CELL LINE; CELL MEMBRANE; CYTOSOL; EMBRYO; GENES, RAS; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; HUMANS; IMMUNOSORBENT TECHNIQUES; KIDNEY; MUTATION; PROTEIN ISOPRENYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030068062     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(95)01416-0     Document Type: Article

References (44)

1. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827.
2. Kaziro, Y., Itoh, H., Kozasa, T., Nakafuku, M. and Satoh, T. (1991) Annu. Rev. Biochem. 60, 349-400.
3. Lowy, D.R. and Willumsen, B.M. (1993) Annu. Rev. Biochem. 62, 851-891.
4. Clarke, S. (1992) Annu. Rev. Biochem. 61, 355-386.
5. Cox, A.D. and Der, C.J. (1992) Curr. Opin. Cell Biol. 4, 1008-1016.
6. Willumsen, B.M., Norris, K., Papageorge, A.G., Hubbert, N.L. and Lowy, D.R. (1984) EMBO J. 3, 2581-2585.
7. Tamanoi, F. (1993) Trends Biochem. Sci. 18, 349-353.
8. Gibbs, J.B., Oliff, A. and Kohl, N.E. (1994) Cell 77, 175-178.
9. Bos, J.L. (1989) Cancer Res. 49, 4682-4689.
10. Kohl, N.E., Mosser, S.D., deSolms, S.J., Giuliani, E.A., Pompliano, D.L., Graham, S.L., Smith, R.L., Scolnick, E.M., Oliff, A. and Gibbs, J.B. (1993) Science 260, 1934-1937.
11. James, G.L., Goldstein, J.L., Brown, M.S., Rawson, T.E., Somers T.C., McDowell, R.S., Crowley, C.W., Lucas, B.K., Levinson, A.D. and Mersters, J.C., Jr. (1993) Science 260, 1937-1942.
12. James, G.L., Brown, M.S., Cobb, M.H. and Goldstein, J.L. (1994) J. Biol. Chem. 269, 27705-27714.
13. Prendergast, G.C., Davide, J.P., deSolms, S.J., Giuliani, E.A., Graham, S.L., Gibbs, J.B., Oliff, A. and Kohl, N.E. (1994) Mol. Cell. Biol. 14, 4193-4202.
14. Gibbs, J.B., Schaber, M.D., Schofield, T.L., Scolnick, E.M. and Sigal, I.S. (1989) Proc. Natl. Acad. Sci. USA 86, 6630-6634.
15. Michaeli, T., Field, J., Ballester, R., O'Neill, K. and Wigler, M. (1989) EMBO J. 8, 3039-3044.
16. Benito, M., Porras, A., Nebreda, A.R. and Santos, E. (1991) Science 253, 565-568
17. Stacy, D.W., Feig, L.A. and Gibbs, J.B. (1991) Mol. Cell. Biol. 11, 4053-4064.
18. Koide, H., Satoh, T., Nakafuku, M. and Kaziro, Y. (1993) Proc. Natl. Acad. Sci. USA 90, 8683-8686.
19. Moodie, S.A., Willumsen, B.M., Weber, M.J. and Wolfman, A. (1993) Science 260, 1658-1661.
20. Van Aelst, L., Barr, M., Marcus, S., Polverino, A. and Wigler, M. (1993) Proc. Natl. Acad. Sci. USA 90, 6213-6217.
21. Vojtek, A.B., Hollenberg, S.M. and Cooper, J. (1993) Cell 74, 205-214.
22. Warne, P.H., Viciana, P.R. and Downward, J. (1993) Nature (London) 364, 352-355.
23. Morrison, D.K. (1990) Cancer Cells (1990) 2, 377-382.
24. Daum, G., Eisenmann-Tappe, I., Fries, H.-W., Troppmair, J. and Rapp, U.R. (1994) Trends Biochem. Sci. 19, 474-480.
25. Avruch, J., Zhang, X.-f. and Kyriakis, J.M. (1994) Trends Biochem. Sci. 19, 279-283.
26. Nishida, E. and Gotoh, Y. (1993) Trends Biochem. Sci. 18, 128-131.
27. Marshall, C.J. (1994) Curr. Opin. Genet. Dev. 4, 82-89.
28. Leevers, S.J., Paterson, H.F. and Marshall, C.J. (1994) Nature (London) 369, 411-414.
29. Stokoe, D, Macdonald, S.G., Cadwallader, K., Symons, M. and Hancock, J.F. (1994) Science 264, 1463-1467.
30. Gotoh, Y. Matsuda, S., Takenaka, K., Hattori, S., Iwamatsu, A., Ishikawa, M., Kosako, H. and Nishida, E. (1994) Oncogene 9, 1891-1898.
31. Kosako, H., Nishida, E. and Gotoh, Y. (1993) EMBO J. 12, 787-794.
32. Andersson, S., Davis, D.N., Dahlback, H., Jornvall, H. and Russell, D.W. (1989) J. Biol. Chem. 264, 8222-8229.
33. Ito, A., Satoh, T., Kaziro, Y. and Itoh, H. (1995) FEBS Lett. 368, 183-187.
34. Williams, N.D., Roberts, T.M. and Li, P. (1992) Proc. Natl. Acad. Sci. USA 89, 2922-2926.
35. Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Waterfield, M. and Downward, J. (1994) Nature (London) 370, 527-532.
36. Hofer, F., Fields, S., Schneider, C. and Martin, G.S. (1994) Proc. Natl. Acad. Sci. USA 91, 11089-11093.
37. Kikuchi, A., Demo, S.D., Ye, Z.H., Chen, Y.W. and Williams, L.T. (1994) Mol. Cell. Biol. 14, 7483-7491.
38. Spaargaren, M. and Bischoff, J.R. (1994) Proc. Natl. Acad. Sci. USA 91, 12609-12613.
39. Ridley, A.J., Paterson, H.F., Johnson, C.L., Diekmann, D. and Hall, A. (1992) Cell 70, 401-410.
40. Khosravi-Far, R., Solski, P.A., Clark, G.J., Kinch, M.S. and Der, C.J. (1995) Mol. Cell. Biol. 15, 6443-6453.
41. Qiu, R.-G., Chen, L., Kirn, D., McCormick, F. and Symons, M. (1995) Nature (London) 374, 457-459.
42. Ridley, A.J. and Hall, A. (1992) Cell 70, 389-399.
43. Aitken, A. (1995) Trends Biochem. Sci. 20, 95-97.
44. Stancato, L.F., Chow, Y.-H., Hutchison, K.A., Perdew, G.H., Jove, R. and Pratt, W.B. (1993) J. Biol. Chem. 268, 21711-21716.