Immunosuppressant FK506 activates NF-κB through the proteasome-mediated degradation of IκBα. Requirement for IκBα N-terminal phosphorylation but not ubiquitination sites

Journal of Biological Chemistry

Volumn 274, Issue 49, 1999, Pages 34657-34662

  Zhang, Yong Kang ^b   Sun, Xiangao ^b   Muraoka, Kei Ichi ^b   Ikeda, Akiko ^b   Miyamoto, Shigeki ^a   Shimizu, Hiroko ^b   Yoshioka, Katsuji ^b   Yamamoto, Ken Ichi ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 1; PROTEASOME; PROTEASOME INHIBITOR; TACROLIMUS;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA-BINDING PROTEINS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; LUCIFERASES; LYSINE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NF-KAPPA B; PHOSPHORYLATION; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; SERINE; TACROLIMUS; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; UBIQUITINS;

EID: 0033521112     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.49.34657     Document Type: Article

References (43)

1. Verma, I. M., Stevenson, J. K., Schwarz, E. M., van Antwerp, D., and Miyamoto, S. (1995) Genes Dev. 9, 2733-2735
2. Baldwin, A. S., Jr. (1996) Annu. Rev. Immunol. 14, 649-683
3. May, M. J., and Ghosh, S. (1998) Immunol. Today 19, 80-88
4. Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., and Siebenlist, U. (1995) Science 267, 1485-1488
5. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, Y., and Ballard, D. W. (1995) Mol. Cell. Biol. 15, 2809-2818
6. DiDonato, J., Mercurio, F., Rossete, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin, M. (1996) Mol. Cell. Biol. 16, 1295-1304
7. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D. C., Ballard, D. W., and Maniatis, T. (1995) Genes Dev. 9, 1586-1597
8. Scherer, D. C., Brockman, J. A., Chen, Z., Maniatis, T., and Ballard, D. W. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11259-11263
9. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. (1994) Cell 78, 773-785
10. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. (1997) Nature 388, 548-554
11. Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D., Cao, Z., and Rothe, M. (1997) Cell 90, 373-383
12. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., and Karin, M. (1997) Cell 91, 243-252
13. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M., and Mann, M. (1997) Science 278, 860-866
14. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V. (1997) Science 278, 866-869
15. Ghoda, L., Lin, X., and Greene, W. C. (1997) J. Biol. Chem. 272, 21281-21288
16. Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J., Tatsumi, Y., Kanamaru, A., and Akira, S. (1999) Int. Immunol., 11, 1357-1362
17. Schreiber, S. L., and Crabtree, G. R. (1992) Immunol. Today 13, 136-142
18. Muraoka, K., Fujimoto, K., Sun, X., Yoshioka, K., Shimizu, K., Yagi, M., Bose, H., Jr., Miyazaki, I., and Yamamoto, K. (1996) J. Clin. Invest. 97, 2433-2439
19. Traenckner, B., Wilk, S., and Baeuerle, P. A. (1994) EMBO J. 13, 5433-5441
20. Seeger, M., Kraft, R., Ferrell, K., Bech-Otschir, D., Dumdey, R., Schade, R., Gordon, C., Naumann, M., and Dubiel, W. (1998) FASEB J. 470, 469-478
21. Dick, L. R., Cruikshank, A. A., Destree, A. T., Grenier, L., McCormack, T. A., Melandori, F. D., Nunes, S. L., Palombella, V. J., Parent, L. A., Plamondon, L., and Stein, R. L. (1997) J. Biol. Chem. 272, 182-188
22. Figueiedo-Pereira, M. E., Banik, N., and Wilk, S. (1994) J. Neurochem. 62, 1989-1994
23. Lazebnik, Y. A., Kaufmann, S. H., Dosnoyers, S., Poirier, G. G., and Earnshow, W. C. (1994) Nature 371, 346-347
24. Haskil, S., Beg, A. A., Tompkins, S. M., Morris, J. S., Yurochko, A. D., Sampson-Johannes, A., Mondal, K., and Baldwin, A. S., Jr. (1991) Cell 65, 1281-1289
25. Mizushima, S., and Nagata, S. (1990) Nucleic Acids Res. 18, 5322-5324
26. Onishi, I., Tani, T., Hashimoto, T., Shimizu, K., Yagi, M., Yamamoto, K., and Yoshioka, K. (1997) FEBS Lett. 420, 201-204
27. Beg, A. A., Finco, T. S., Nantermet, P. J., and Baldwin, A. S., Jr. (1993) Mol. Cell. Biol. 13, 3301-3310
28. Imbert, V., Rupee, R. A., Livoisi, A., Pahl, H. L., Traenckner, E. B., Mueller-Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeuerle, P. A., and Peyron, J. (1996) Cell 86, 787-798
29. Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H., and Okumura, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3537-3542
30. Lee, F. S., Peters, R. T., Dang, L., and Maniatis, T. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9319-9324
31. Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., and Akira, S. (1999) Science 284, 313-316
32. Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T., Ellisman, M., Johnson, R., and Karin, M. (1999) Science 284, 316-320
33. Li, Q., van Antwerp, D., Mercurio, F., Lee, K., and Verma, I. M. (1999) Science 284, 321-325
34. Blenis, J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5889-5892
35. Stugill, T. W., Ray, L. B., Erikson, E., and Maller, J. L. (1988) Nature 334, 715-718
36. Dumon, F. J., Staruch, M. J., Koprak, S. J., Siekierka, J. J., Lin, C. S., Harrison, R., Sewell, T., Kindt, V. M., Beattie, T. R., Wyvratt, M., and Sigal, N. H. (1992) J. Exp. Med. 176, 751-760
37. Pahl, H. L., and Baeuerle, P. A. (1995) EMBO J. 14, 2580-2588
38. Brillantes, A. B., Ondrias, K., Scott, A., Kobrinsky, E., Ondrisova, E., Moschella, M. C., Jayaraman, T., Landers, M., Ehlich, B. E., and Marks, A. R. (1994) Cell 77, 512-523
39. Wang, T., Li, B., Danielson, P. D., Shah, P. C., Rockwell, S., Lechleider, R. L., Martin, J., Manganaro, T., and Donahoe, P. K. (1996) Cell 86, 435-444
40. Maniatis, T. (1999) Genes Dev. 13, 505-510
41. Murakami, Y., Mastufuji, S., Kameji, T., Hayashi, S., Igarashi, K., Tamura, T., Tanaka, K., and Ichihara, A. (1992) Nature 360, 597-599
42. Jariel-Encontre, I., Pariat, M., Martin, F., Carillo, S., Salvat, C., and Piechaczyk, M. (1995) J. Biol. Chem. 270, 11623-11627
43. Krappmann, D., Wulczyn, F. G., and Scheidereit, C. (1996) EMBO J. 15, 6716-6726