-
1
-
-
0025978976
-
Man-made antibodies
-
Winter, G., Milstein, C. Man-made antibodies. Nature 1991, 349: 293-9.
-
(1991)
Nature
, vol.349
, pp. 293-299
-
-
Winter, G.1
Milstein, C.2
-
2
-
-
0026613775
-
Antibody conjugates for the treatment of cancer
-
Pietersz, G.A., McKenzie, I.F. Antibody conjugates for the treatment of cancer. Immunol Rev 1992, 129: 57-80.
-
(1992)
Immunol Rev
, vol.129
, pp. 57-80
-
-
Pietersz, G.A.1
McKenzie, I.F.2
-
3
-
-
0027156735
-
Immunotoxins: Magic bullets or misguided missiles?
-
Vitetta, E.S., Thorpe, P.E., Uhr, J.W. Immunotoxins: Magic bullets or misguided missiles? Immunol Today 1993, 14: 252-9.
-
(1993)
Immunol Today
, vol.14
, pp. 252-259
-
-
Vitetta, E.S.1
Thorpe, P.E.2
Uhr, J.W.3
-
4
-
-
0345678344
-
Design of antitumor prodrugs: Substrates for antibody targeted enzymes
-
Jungheim, L.N., Shepherd, T.A. Design of antitumor prodrugs: Substrates for antibody targeted enzymes. Chem Rev 1994, 94: 1553-6.
-
(1994)
Chem Rev
, vol.94
, pp. 1553-1556
-
-
Jungheim, L.N.1
Shepherd, T.A.2
-
5
-
-
0024722750
-
The first Bagshawe lecture. Towards generating cytotoxic agents at cancer sites
-
Bagshawe, K.D. The first Bagshawe lecture. Towards generating cytotoxic agents at cancer sites. Brit J Cancer 1989, 60: 275-81.
-
(1989)
Brit J Cancer
, vol.60
, pp. 275-281
-
-
Bagshawe, K.D.1
-
6
-
-
0030024847
-
Antibody-enzyme conjugates for cancer therapy
-
Melton, R.G., Sherwood, R.F. Antibody-enzyme conjugates for cancer therapy. J Natl Cancer Inst 1996, 88: 153-65.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 153-165
-
-
Melton, R.G.1
Sherwood, R.F.2
-
7
-
-
0029928543
-
Development of prodrugs for ADEPT (antibody-directed enzyme prodrug therapy)
-
Niculescu-Duvaz, I., Springer, C.J. Development of prodrugs for ADEPT (antibody-directed enzyme prodrug therapy). Exp Opin Invest Drugs 1996, 3: 289-308.
-
(1996)
Exp Opin Invest Drugs
, vol.3
, pp. 289-308
-
-
Niculescu-Duvaz, I.1
Springer, C.J.2
-
8
-
-
0028972656
-
Antibody-directed enzyme prodrug therapy (ADEPT): A targeting strategy in cancer chemotherapy
-
Niculescu-Duvaz, I., Springer, C.J. Antibody-directed enzyme prodrug therapy (ADEPT): A targeting strategy in cancer chemotherapy. Curr Med Chem 1995, 2: 687-706.
-
(1995)
Curr Med Chem
, vol.2
, pp. 687-706
-
-
Niculescu-Duvaz, I.1
Springer, C.J.2
-
9
-
-
0028455028
-
Tumor targeting: Activation of prodrugs by enzyme-monoclonal antibody conjugates
-
Heunnekens, F.M. Tumor targeting: Activation of prodrugs by enzyme-monoclonal antibody conjugates. Trends Biotechnol 1994, 12: 234-9.
-
(1994)
Trends Biotechnol
, vol.12
, pp. 234-239
-
-
Heunnekens, F.M.1
-
10
-
-
0028592664
-
Antibody directed enzyme prodrug therapy (ADEPT): A review of some theoretical, experimental and clinical aspects
-
Bagshawe, K.D., Sharma, S.K., Springer, C.J., Rogers, G.T. Antibody directed enzyme prodrug therapy (ADEPT): A review of some theoretical, experimental and clinical aspects. Ann Oncol 1994, 5: 879-91.
-
(1994)
Ann Oncol
, vol.5
, pp. 879-891
-
-
Bagshawe, K.D.1
Sharma, S.K.2
Springer, C.J.3
Rogers, G.T.4
-
11
-
-
0028963579
-
Antibody-directed enzyme prodrug therapy: A review
-
Bagshawe, K.D. Antibody-directed enzyme prodrug therapy: A review. Drug Dev Res 1995, 34: 220-30.
-
(1995)
Drug Dev Res
, vol.34
, pp. 220-230
-
-
Bagshawe, K.D.1
-
12
-
-
0025014962
-
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
-
Jain, R.K. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res 1990, 50 (Suppl): 814-9.
-
(1990)
Cancer Res
, vol.50
, Issue.SUPPL.
, pp. 814-819
-
-
Jain, R.K.1
-
13
-
-
0024232289
-
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumours: Significance of elevated interstitial pressure
-
Jain, R.K., Baxter, LT. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumours: Significance of elevated interstitial pressure. Cancer Res 1988, 48: 7022-32.
-
(1988)
Cancer Res
, vol.48
, pp. 7022-7032
-
-
Jain, R.K.1
Baxter, L.T.2
-
14
-
-
0023256856
-
Localization of radioiodine conjugated to the monoclonal antibody HMFG2 in human ovarian carcinoma: Assessment of intravenous and intraperitoneal routes of administration
-
Ward, B.C., Mather, S.J., Hawkins, L.R. et al. Localization of radioiodine conjugated to the monoclonal antibody HMFG2 in human ovarian carcinoma: Assessment of intravenous and intraperitoneal routes of administration. Cancer Res 1987, 47: 4719-23.
-
(1987)
Cancer Res
, vol.47
, pp. 4719-4723
-
-
Ward, B.C.1
Mather, S.J.2
Hawkins, L.R.3
-
15
-
-
0025147443
-
Quantitative analysis of antibody localization in human metastatic colon cancer: A phase I study of monoclonal antibody A33
-
Welt, S., Divgi, C.R., Real, F.X. et al. Quantitative analysis of antibody localization in human metastatic colon cancer: A phase I study of monoclonal antibody A33. J Clin Oncol 1990, 8: 1894-906.
-
(1990)
J Clin Oncol
, vol.8
, pp. 1894-1906
-
-
Welt, S.1
Divgi, C.R.2
Real, F.X.3
-
16
-
-
0025943406
-
Regional heterogeneity and complementation in the expression of the tumour-associated glycoprotein 72 epitopes in colorectal cancer
-
Muraro, R., Frati, L., Bei, R. et al. Regional heterogeneity and complementation in the expression of the tumour-associated glycoprotein 72 epitopes in colorectal cancer. Cancer Res 1991, 51: 5378-83.
-
(1991)
Cancer Res
, vol.51
, pp. 5378-5383
-
-
Muraro, R.1
Frati, L.2
Bei, R.3
-
17
-
-
0028878938
-
Problems of delivery of monoclonal antibodies. Pharmaceutical and pharmacokinetic solutions
-
Reilly, R.M., Sanhu, J., Alvarez-Díez, T.M., Gallinger, S., Kirsh, J., Stern, H. Problems of delivery of monoclonal antibodies. Pharmaceutical and pharmacokinetic solutions. Clin Pharmacokinet 1995, 28: 126-42.
-
(1995)
Clin Pharmacokinet
, vol.28
, pp. 126-142
-
-
Reilly, R.M.1
Sanhu, J.2
Alvarez-Díez, T.M.3
Gallinger, S.4
Kirsh, J.5
Stern, H.6
-
18
-
-
0025880550
-
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies
-
Yuan, F., Baxter, L.T., Jain, R.K. Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. Cancer Res 1991, 51: 3119-30.
-
(1991)
Cancer Res
, vol.51
, pp. 3119-3130
-
-
Yuan, F.1
Baxter, L.T.2
Jain, R.K.3
-
19
-
-
0030020857
-
Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: Comparison with experimental data
-
Baxter, L.T., Jain, R.K. Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: Comparison with experimental data. Brit J Cancer 1996, 73: 447-56.
-
(1996)
Brit J Cancer
, vol.73
, pp. 447-456
-
-
Baxter, L.T.1
Jain, R.K.2
-
20
-
-
0027357432
-
Generation of cytotoxic agents by targeted enzymes
-
Senter, P.D., Wallace, P.M., Svensson, H.P. et al. Generation of cytotoxic agents by targeted enzymes. Bioconj Chem 1993, 4: 3-9.
-
(1993)
Bioconj Chem
, vol.4
, pp. 3-9
-
-
Senter, P.D.1
Wallace, P.M.2
Svensson, H.P.3
-
21
-
-
0025373638
-
Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model
-
Sharma, S.K., Bagshawe, K.D., Burke, P.J., Boden, R.W., Rogers, G.T. Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model. Brit J Cancer 1990, 61: 659-62.
-
(1990)
Brit J Cancer
, vol.61
, pp. 659-662
-
-
Sharma, S.K.1
Bagshawe, K.D.2
Burke, P.J.3
Boden, R.W.4
Rogers, G.T.5
-
22
-
-
0028335819
-
Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
-
Wallace, P.M., MacMaster, J.F., Smith, V.F., Kerr, D.E., Senter, P.D., Cosand, W.L. Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res 1994, 54: 2719-23.
-
(1994)
Cancer Res
, vol.54
, pp. 2719-2723
-
-
Wallace, P.M.1
MacMaster, J.F.2
Smith, V.F.3
Kerr, D.E.4
Senter, P.D.5
Cosand, W.L.6
-
23
-
-
0028090161
-
Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
-
Mauger, A.B., Burke, P.B., Somani, H.H., Freidlos, F, Knox, RJ. Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme. J Med Chem 1994, 37: 3452-8.
-
(1994)
J Med Chem
, vol.37
, pp. 3452-3458
-
-
Mauger, A.B.1
Burke, P.B.2
Somani, H.H.3
Freidlos, F.4
Knox, R.J.5
-
24
-
-
0029884764
-
Recent developments in the design of bioreductive drugs
-
Denny, W.A., Wilson, W.R., Hay, M.P. Recent developments in the design of bioreductive drugs. Brit J Cancer 1996, 74(Suppl. 27): 532-8.
-
(1996)
Brit J Cancer
, vol.74
, Issue.27 SUPPL.
, pp. 532-538
-
-
Denny, W.A.1
Wilson, W.R.2
Hay, M.P.3
-
25
-
-
0028789127
-
Antibody-directed enzyme prodrug therapy (ADEPT) for treatment of major solid tumour disease
-
Blakey, D.C., Burke, P.J., Davies, D.H. et al. Antibody-directed enzyme prodrug therapy (ADEPT) for treatment of major solid tumour disease. Biochem Soc Trans 1995, 23: 1047-50.
-
(1995)
Biochem Soc Trans
, vol.23
, pp. 1047-1050
-
-
Blakey, D.C.1
Burke, P.J.2
Davies, D.H.3
-
26
-
-
0023619243
-
Antibody directed enzymes revive anti-cancer prodrugs concept
-
Bagshawe, K.D. Antibody directed enzymes revive anti-cancer prodrugs concept. Brit J Cancer 1987, 56: 531-2.
-
(1987)
Brit J Cancer
, vol.56
, pp. 531-532
-
-
Bagshawe, K.D.1
-
27
-
-
0024246527
-
A cytotoxic agent can be generated selectively at cancer sites
-
Bagshawe, K.D., Springer, C.J., Searle, F. et al. A cytotoxic agent can be generated selectively at cancer sites. Brit J Cancer 1988, 58: 700-3.
-
(1988)
Brit J Cancer
, vol.58
, pp. 700-703
-
-
Bagshawe, K.D.1
Springer, C.J.2
Searle, F.3
-
28
-
-
0025189891
-
Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2
-
Springer, C.J., Antoniw, P., Bagshawe, K.D., Searle, F., Bisset, G.M., Jarman, M. Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J Med Chem 1990, 33: 677-81.
-
(1990)
J Med Chem
, vol.33
, pp. 677-681
-
-
Springer, C.J.1
Antoniw, P.2
Bagshawe, K.D.3
Searle, F.4
Bisset, G.M.5
Jarman, M.6
-
29
-
-
0026335039
-
Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethylbenzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
-
Springer, C.J., Antoniw, P., Bagshawe, K.D., Wilman, D.E. Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethylbenzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT). Anticancer Drug Des 1991, 6: 467-79.
-
(1991)
Anticancer Drug des
, vol.6
, pp. 467-479
-
-
Springer, C.J.1
Antoniw, P.2
Bagshawe, K.D.3
Wilman, D.E.4
-
30
-
-
0025955579
-
Ablation of human choriocarcinoma xenografts in nude mice by an antibody-directed enzyme prodrug therapy with three novel compounds
-
Springer, C.J., Bagshawe, K.D., Sharma, S.K. et al. Ablation of human choriocarcinoma xenografts in nude mice by an antibody-directed enzyme prodrug therapy with three novel compounds. Eur J Cancer 1991, 21: 1361-6.
-
(1991)
Eur J Cancer
, vol.21
, pp. 1361-1366
-
-
Springer, C.J.1
Bagshawe, K.D.2
Sharma, S.K.3
-
31
-
-
0025720744
-
Antibody directed enzyme prodrug therapy (ADEPT): A three phase system
-
Sharma, S.K., Bagshawe, K.D., Springer, C.J. et al. Antibody directed enzyme prodrug therapy (ADEPT): A three phase system. Disease Markers 1991, 9: 225-31.
-
(1991)
Disease Markers
, vol.9
, pp. 225-231
-
-
Sharma, S.K.1
Bagshawe, K.D.2
Springer, C.J.3
-
32
-
-
0027538834
-
Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with benzoic acid mustard prodrug
-
Blakey, D.C., Valcaccia, B.E., East, S. et al. Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with benzoic acid mustard prodrug. Cell Biophys 1993, 22: 1-8.
-
(1993)
Cell Biophys
, vol.22
, pp. 1-8
-
-
Blakey, D.C.1
Valcaccia, B.E.2
East, S.3
-
33
-
-
0028014458
-
Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy
-
Sharma, S.K. Bagshawe, K.D., Burke, P.J. et al. Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy. Cancer 1994, 73 (Suppl): 1114-20.
-
(1994)
Cancer
, vol.73
, Issue.SUPPL.
, pp. 1114-1120
-
-
Sharma, S.K.1
Bagshawe, K.D.2
Burke, P.J.3
-
34
-
-
0027212228
-
Tumour necrosis factor increases tumour uptake of co-administered antibody-carboxypeptidase G2 conjugate
-
Melton, R.G., Rowland, J.A., Pietersz, G.A., Sherwood, R.F., McKenzie, I.F. Tumour necrosis factor increases tumour uptake of co-administered antibody-carboxypeptidase G2 conjugate. Eur J Cancer 1993, 29A; 1177-83.
-
(1993)
Eur J Cancer
, vol.29 A
, pp. 1177-1183
-
-
Melton, R.G.1
Rowland, J.A.2
Pietersz, G.A.3
Sherwood, R.F.4
McKenzie, I.F.5
-
35
-
-
0028694296
-
Antibody-directed enzyme prodrug therapy (ADEPT): A three phase study in ovarian tumor xenografts
-
Sharma, S.K., Boden, J.A., Springer, C.J., Burke, P.J., Bagshawe, K.D. Antibody-directed enzyme prodrug therapy (ADEPT): A three phase study in ovarian tumor xenografts. Cell Biophys 1994, 24/25: 219-28.
-
(1994)
Cell Biophys
, vol.24-25
, pp. 219-228
-
-
Sharma, S.K.1
Boden, J.A.2
Springer, C.J.3
Burke, P.J.4
Bagshawe, K.D.5
-
36
-
-
0007351186
-
Antibody-enzyme conjugates can generate cytotoxic drugs from inactive precursors at tumor sites
-
Bagshawe, K.D., Sharma, S.K., Springer, C.J. et al. Antibody-enzyme conjugates can generate cytotoxic drugs from inactive precursors at tumor sites. Antibody Immunoconj Radiopharm 1991, 4: 915-22.
-
(1991)
Antibody Immunoconj Radiopharm
, vol.4
, pp. 915-922
-
-
Bagshawe, K.D.1
Sharma, S.K.2
Springer, C.J.3
-
37
-
-
0028122014
-
Novel prodrugs of alkylating agents derived from 2-fluoro- And 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy
-
Springer, C.J., Niculescu-Duvaz, I., Pedley, B.R. Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy. J Med Chem 1994, 37: 2361-70.
-
(1994)
J Med Chem
, vol.37
, pp. 2361-2370
-
-
Springer, C.J.1
Niculescu-Duvaz, I.2
Pedley, B.R.3
-
38
-
-
0029145803
-
Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs
-
Springer, C.J., Niculescu-Duvaz, I. Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs. Anti-Cancer Drug Des 1995, 10: 361-72.
-
(1995)
Anti-Cancer Drug des
, vol.10
, pp. 361-372
-
-
Springer, C.J.1
Niculescu-Duvaz, I.2
-
39
-
-
0029621825
-
Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: A new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT)
-
Springer, C.J., Dowell, R., Burke, P.J. et al. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: A new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT). J Med Chem 1995, 38: 5051-65.
-
(1995)
J Med Chem
, vol.38
, pp. 5051-5065
-
-
Springer, C.J.1
Dowell, R.2
Burke, P.J.3
-
40
-
-
13344276593
-
New mustard prodrugs for antibody-directed enzyme prodrug therapy: Alternatives to the amide link
-
Dowell, R.I., Springer, C.J., Davies, D.H. et al. New mustard prodrugs for antibody-directed enzyme prodrug therapy: Alternatives to the amide link. J Med Chem 1996, 39: 1100-5.
-
(1996)
J Med Chem
, vol.39
, pp. 1100-1105
-
-
Dowell, R.I.1
Springer, C.J.2
Davies, D.H.3
-
41
-
-
10544236672
-
ZD2767, a new adept system which results in tumour regressions in colorectal tumour xenografts
-
Blakey, D.C., Burke, P.J., Davies, D.H. et al. ZD2767, a new adept system which results in tumour regressions in colorectal tumour xenografts. Brit J Cancer 1995, 71 (Suppl): 12.
-
(1995)
Brit J Cancer
, vol.71
, Issue.SUPPL.
, pp. 12
-
-
Blakey, D.C.1
Burke, P.J.2
Davies, D.H.3
-
42
-
-
0028848101
-
Antitumoureffects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
-
Blakey, D.C., Davies, D.H., Dowell, R.I. et al. Antitumoureffects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs. Brit J Cancer 1995, 72: 1083-8.
-
(1995)
Brit J Cancer
, vol.72
, pp. 1083-1088
-
-
Blakey, D.C.1
Davies, D.H.2
Dowell, R.I.3
-
43
-
-
0022481301
-
1H NMR of cephalosporoate intermediates in aqueous solution during the hydrazinolysis and β-lactamase-catalysed hydrolysis of cephalosporins with 3′ leaving groups: Kinetics and equilibria of the 3′ elimination reaction
-
1H NMR of cephalosporoate intermediates in aqueous solution during the hydrazinolysis and β-lactamase-catalysed hydrolysis of cephalosporins with 3′ leaving groups: Kinetics and equilibria of the 3′ elimination reaction. J Amer Chem Soc 1986, 108: 5328-33.
-
(1986)
J Amer Chem Soc
, vol.108
, pp. 5328-5333
-
-
Pratt, R.F.1
Faraci, W.S.2
-
44
-
-
0022472344
-
Mechanism of inhibition of RTEM-2 β-lactamase by cephamycins: Relative importance of the 7α-methoxy group and the 3′ leaving group
-
Faraci, W.S., Pratt, R.F. Mechanism of inhibition of RTEM-2 β-lactamase by cephamycins: Relative importance of the 7α-methoxy group and the 3′ leaving group. Biochemistry 1986, 25: 2934-41.
-
(1986)
Biochemistry
, vol.25
, pp. 2934-2941
-
-
Faraci, W.S.1
Pratt, R.F.2
-
45
-
-
0025098415
-
Cephalosporin 3′-quinolone esters with a dual mode of action
-
Albrecht, H.A., Beskid, G., Chan, K-K. et al. Cephalosporin 3′-quinolone esters with a dual mode of action. J Med Chem 1990, 33: 77-86.
-
(1990)
J Med Chem
, vol.33
, pp. 77-86
-
-
Albrecht, H.A.1
Beskid, G.2
Chan, K.-K.3
-
46
-
-
0026826545
-
Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug
-
Svensson, H.P., Kadow, J.F., Vrudhula, V.M., Wallace, P.M., Senter, P.D. Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug. Bioconj Chem 1992, 3: 176-81.
-
(1992)
Bioconj Chem
, vol.3
, pp. 176-181
-
-
Svensson, H.P.1
Kadow, J.F.2
Vrudhula, V.M.3
Wallace, P.M.4
Senter, P.D.5
-
47
-
-
0027655158
-
Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates
-
Vrudhula, V.M., Svennson, H.P., Kennedy, K.A., Senter, P.D., Wallace, P.M. Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates. Bioconj Chem 1993, 4: 334-40.
-
(1993)
Bioconj Chem
, vol.4
, pp. 334-340
-
-
Vrudhula, V.M.1
Svennson, H.P.2
Kennedy, K.A.3
Senter, P.D.4
Wallace, P.M.5
-
48
-
-
0011341888
-
Immunogenicity of antibody-enzyme conjugates in antibody directed enzyme prodrug therapy
-
Sharma, S.K., Bagshawe, K.D., Melton, R.G. Immunogenicity of antibody-enzyme conjugates in antibody directed enzyme prodrug therapy. Antibody Immunoconj Radiopharm 1991, 4: 226.
-
(1991)
Antibody Immunoconj Radiopharm
, vol.4
, pp. 226
-
-
Sharma, S.K.1
Bagshawe, K.D.2
Melton, R.G.3
-
49
-
-
0025864963
-
A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer
-
Shepherd, T.A., Jungheim, L.N., Meyer, D.L., Starling, J.J. A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer. Bioorg Med Chem Lett 1991, 1: 21-6.
-
(1991)
Bioorg Med Chem Lett
, vol.1
, pp. 21-26
-
-
Shepherd, T.A.1
Jungheim, L.N.2
Meyer, D.L.3
Starling, J.J.4
-
50
-
-
0026562808
-
Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: Substrates for an antibody-targeted enzyme
-
Jungheim, L.A., Shepherd, T.A., Meyer, D.L. Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: Substrates for an antibody-targeted enzyme. J Org Chem 1992, 57: 2334-40.
-
(1992)
J Org Chem
, vol.57
, pp. 2334-2340
-
-
Jungheim, L.A.1
Shepherd, T.A.2
Meyer, D.L.3
-
51
-
-
0026487592
-
Preparation and characterization of a beta-lactamase-Fab' conjugate for the site-specific activation of oncolytic agents
-
Meyer, M.L., Jungheim, L.N., Mikolajczyk, S.D., Shepherd T.A., Starling, J.J., Ahlem, C.N. Preparation and characterization of a beta-lactamase-Fab' conjugate for the site-specific activation of oncolytic agents. Bioconj Chem 1992, 3: 42-8.
-
(1992)
Bioconj Chem
, vol.3
, pp. 42-48
-
-
Meyer, M.L.1
Jungheim, L.N.2
Mikolajczyk, S.D.3
Shepherd, T.A.4
Starling, J.J.5
Ahlem, C.N.6
-
52
-
-
0027220125
-
Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
-
Meyer, M.L., Jungheim, L.N. Law, K.L. et al. Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res 1993, 53: 3956-63.
-
(1993)
Cancer Res
, vol.53
, pp. 3956-3963
-
-
Meyer, M.L.1
Jungheim, L.N.2
Law, K.L.3
-
53
-
-
0029019242
-
In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates
-
Svennson, H.P., Vrudhula, V.M., Emswiler, J.E. et al. In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates. Cancer Res 1995, 55: 2357-65.
-
(1995)
Cancer Res
, vol.55
, pp. 2357-2365
-
-
Svennson, H.P.1
Vrudhula, V.M.2
Emswiler, J.E.3
-
54
-
-
0028939031
-
Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-β-lactamase conjugates
-
Vrudhula, V.M., Svennson, H.P., Senter, P.D. Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-β-lactamase conjugates. J Med Chem 1995, 38: 1380-5.
-
(1995)
J Med Chem
, vol.38
, pp. 1380-1385
-
-
Vrudhula, V.M.1
Svennson, H.P.2
Senter, P.D.3
-
55
-
-
0029340354
-
Poly(ethylene glycol)doxorubicin conjugates containing β-lactamase-sensitive linkers
-
Senter, P.D., Svennson, H.P., Schreiber, G.J., Rodríguez, J.L., Vrudhula, V.M. Poly(ethylene glycol)doxorubicin conjugates containing β-lactamase-sensitive linkers. Bioconj Chem 1995, 6: 389-94.
-
(1995)
Bioconj Chem
, vol.6
, pp. 389-394
-
-
Senter, P.D.1
Svennson, H.P.2
Schreiber, G.J.3
Rodríguez, J.L.4
Vrudhula, V.M.5
-
56
-
-
0029328639
-
Site-specific prodrug activation by β-lactamase conjugates: Preclinical investigation of the efficacy and toxicity of doxorubicin delivered by antibody directed catalysis
-
Meyer, D.L., Law, K.L., Kindle Payne, J. et al. Site-specific prodrug activation by β-lactamase conjugates: Preclinical investigation of the efficacy and toxicity of doxorubicin delivered by antibody directed catalysis. Bioconj Chem 1995, 6: 440-6.
-
(1995)
Bioconj Chem
, vol.6
, pp. 440-446
-
-
Meyer, D.L.1
Law, K.L.2
Kindle Payne, J.3
-
57
-
-
0014024073
-
Cure of mice bearing advanced plasma cell tumours with aniline mustard: The relationship between glucuronidase activity and tumour sensitivity
-
Conners, T.A., Whisson, M.E. Cure of mice bearing advanced plasma cell tumours with aniline mustard: the relationship between glucuronidase activity and tumour sensitivity. Nature 1966, 210: 866-7.
-
(1966)
Nature
, vol.210
, pp. 866-867
-
-
Conners, T.A.1
Whisson, M.E.2
-
58
-
-
0015813383
-
Metabolism of aniline mustard [N,N-di-(2-chloroethyl)aniline]
-
Conners, T.A., Farmer, P.B., Foster, A.B., Gilsenan, A.M., Jarman, M., Tisdale, M.J. Metabolism of aniline mustard [N,N-di-(2-chloroethyl)aniline]. Biochem Pharmacol 1973, 22: 1971-80.
-
(1973)
Biochem Pharmacol
, vol.22
, pp. 1971-1980
-
-
Conners, T.A.1
Farmer, P.B.2
Foster, A.B.3
Gilsenan, A.M.4
Jarman, M.5
Tisdale, M.J.6
-
59
-
-
0015621801
-
Evaluation of aniline mustard in patients with multiple myeloma
-
Kyle, R.A., Costa, G., Cooper, R.M. et al. Evaluation of aniline mustard in patients with multiple myeloma. Cancer Res 1973, 33: 956-60.
-
(1973)
Cancer Res
, vol.33
, pp. 956-960
-
-
Kyle, R.A.1
Costa, G.2
Cooper, R.M.3
-
60
-
-
0017167325
-
Therapeutic trial of aniline mustard in patients with advanced cancer
-
Young, C.W., Yagoda, A., Bittar, E.S., Smith, S.W., Grabstald, H., Whitmore, W. Therapeutic trial of aniline mustard in patients with advanced cancer. Cancer 1976, 38: 1887-95.
-
(1976)
Cancer
, vol.38
, pp. 1887-1895
-
-
Young, C.W.1
Yagoda, A.2
Bittar, E.S.3
Smith, S.W.4
Grabstald, H.5
Whitmore, W.6
-
61
-
-
0026794283
-
Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy
-
Wang, S-M., Chern, J-W., Yeh, M-Y, Ng, J.C., Tung, E., Roffler, S.R. Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy. Cancer Res 1992, 52: 4484-91.
-
(1992)
Cancer Res
, vol.52
, pp. 4484-4491
-
-
Wang, S.-M.1
Chern, J.-W.2
Yeh, M.-Y.3
Ng, J.C.4
Tung, E.5
Roffler, S.R.6
-
62
-
-
0345678344
-
Design of antitumor prodrugs: Substrates for antibody targeted enzymes
-
Jungheim, L.N., Shepherd, T.A. Design of antitumor prodrugs: Substrates for antibody targeted enzymes. Chem Rev 1994, 94: 1553-66.
-
(1994)
Chem Rev
, vol.94
, pp. 1553-1566
-
-
Jungheim, L.N.1
Shepherd, T.A.2
-
63
-
-
0025936081
-
Antineoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate
-
Roffler, S.F., Wang, S-M., Chern, J-W., Yeh, M-Y., Tung, E. Antineoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate. Biochem Pharmacol 1991, 42: 2062-5.
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 2062-2065
-
-
Roffler, S.F.1
Wang, S.-M.2
Chern, J.-W.3
Yeh, M.-Y.4
Tung, E.5
-
64
-
-
0026802983
-
A monoclonalantibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer
-
Haisma, H.J., Boven, E., van Muijen, M., de Jong, J., van der Vijgh, W.J., Pinedo, H.M. A monoclonalantibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer. Brit J Cancer 1992, 66: 474-8.
-
(1992)
Brit J Cancer
, vol.66
, pp. 474-478
-
-
Haisma, H.J.1
Boven, E.2
Van Muijen, M.3
De Jong, J.4
Van Der Vijgh, W.J.5
Pinedo, H.M.6
-
65
-
-
0028718114
-
Comparison of two anthracycline-based prodrugs for activation by a monoclonal antibody-β-glucuronidase conjugate in the specific treatment of cancer
-
Haisma, H.J., van Muijen, M., Pinedo, H.M., Boven, E. Comparison of two anthracycline-based prodrugs for activation by a monoclonal antibody-β-glucuronidase conjugate in the specific treatment of cancer. Cell Biophys 1994, 24/25: 185-92.
-
(1994)
Cell Biophys
, vol.24-25
, pp. 185-192
-
-
Haisma, H.J.1
Van Muijen, M.2
Pinedo, H.M.3
Boven, E.4
-
66
-
-
10544223006
-
A conjugate between deglycosylated human β-glucuronidase and the anti-pancarcinoma monoclonal antibody 323/A3 for activation of a daunorubicin prodrug in antibody-directed enzyme prodrug therapy (ADEPT)
-
Abst 3221
-
Houba, P.H., Boven, E., Leenders, R.G., Scheeren, J.W., Pinedo, H.M., Haisma, H.J. A conjugate between deglycosylated human β-glucuronidase and the anti-pancarcinoma monoclonal antibody 323/A3 for activation of a daunorubicin prodrug in antibody-directed enzyme prodrug therapy (ADEPT). Proc Amer Assoc Cancer Res 1996, 37: Abst 3221.
-
(1996)
Proc Amer Assoc Cancer Res
, vol.37
-
-
Houba, P.H.1
Boven, E.2
Leenders, R.G.3
Scheeren, J.W.4
Pinedo, H.M.5
Haisma, H.J.6
-
67
-
-
10544252457
-
Construction and characterization of a single chain human β-glucuronidase-anti-CD20 antibody fusion protein for antibody-directed enzyme prodrug therapy (ADEPT)
-
Abst 3222
-
Haisma, H.J., Sernee, F, Brakenhoff, R.H., van der Meulen-Muileman, I., Pinedo, H.M., Boven, E. Construction and characterization of a single chain human β-glucuronidase-anti-CD20 antibody fusion protein for antibody-directed enzyme prodrug therapy (ADEPT). Proc Amer Assoc Cancer Res 1996, 37: Abst 3222.
-
(1996)
Proc Amer Assoc Cancer Res
, vol.37
-
-
Haisma, H.J.1
Sernee, F.2
Brakenhoff, R.H.3
Van Der Meulen-Muileman, I.4
Pinedo, H.M.5
Boven, E.6
-
68
-
-
0029085586
-
A monoclonal antibody against human β-glucuronidase for application in antibody-directed enzyme prodrug therapy
-
Haisma, H.J., van Muijen, M., Scheffer, G., Scheper, R.J., Pinedo, H.M., Boven, E. A monoclonal antibody against human β-glucuronidase for application in antibody-directed enzyme prodrug therapy. Hybridoma 1995, 14: 377-82.
-
(1995)
Hybridoma
, vol.14
, pp. 377-382
-
-
Haisma, H.J.1
Van Muijen, M.2
Scheffer, G.3
Scheper, R.J.4
Pinedo, H.M.5
Boven, E.6
-
69
-
-
0024041278
-
Antitumour effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate
-
Senter, P.D., Saulnier, M.G., Schreiber, G.J. et al. Antitumour effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate. Proc Natl Acad Sci USA 1988, 85: 4842-6.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4842-4846
-
-
Senter, P.D.1
Saulnier, M.G.2
Schreiber, G.J.3
-
70
-
-
0025174052
-
Activation of prodrugs by antibody-enzyme conjugates: A new approach to cancer therapy
-
Senter, P.D. Activation of prodrugs by antibody-enzyme conjugates: A new approach to cancer therapy. FASEB J 1990, 4: 188-93.
-
(1990)
FASEB J
, vol.4
, pp. 188-193
-
-
Senter, P.D.1
-
71
-
-
0024446208
-
Enhancement of the in vitro and in vivo antitumour activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates
-
Senter. P.D., Schreiber, G.J., Hirschberg, D.L., Ashe, S.A., Hellstrom, K.E., Hellstrom, I. Enhancement of the in vitro and in vivo antitumour activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates. Cancer Res 1989, 49: 5789-92.
-
(1989)
Cancer Res
, vol.49
, pp. 5789-5792
-
-
Senter, P.D.1
Schreiber, G.J.2
Hirschberg, D.L.3
Ashe, S.A.4
Hellstrom, K.E.5
Hellstrom, I.6
-
72
-
-
0025186181
-
Specific activation of the prodrug mitomycin phosphate by a specific anti-CD30/anti-alkaline phosphatase monoclonal antibody
-
Sahin, U., Hartmann, F., Senter, P. et al. Specific activation of the prodrug mitomycin phosphate by a specific anti-CD30/anti-alkaline phosphatase monoclonal antibody. Cancer Res 1990, 50: 6944-8.
-
(1990)
Cancer Res
, vol.50
, pp. 6944-6948
-
-
Sahin, U.1
Hartmann, F.2
Senter, P.3
-
73
-
-
0026212613
-
In vitro and in vivo effects of antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate
-
Wallace, P.M., Senter P.D. In vitro and in vivo effects of antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate. Bioconj Chem 1991, 2: 349-52.
-
(1991)
Bioconj Chem
, vol.2
, pp. 349-352
-
-
Wallace, P.M.1
Senter, P.D.2
-
74
-
-
0028144884
-
Clinical and pharmacokinetic overview of parenteral etoposide phosphate
-
Schacter, L.P, Igwemezie, L.N., Seyedsadr, M. et al. Clinical and pharmacokinetic overview of parenteral etoposide phosphate. Cancer Chemother Pharmacol 1994, 34 (Suppl): 58-63.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, Issue.SUPPL.
, pp. 58-63
-
-
Schacter, L.P.1
Igwemezie, L.N.2
Seyedsadr, M.3
-
75
-
-
0028091914
-
Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates
-
Wallace, P.M., Senter, P.D. Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates. Meth Find Exp Clin Pharmacol 1994, 17: 505-12.
-
(1994)
Meth Find Exp Clin Pharmacol
, vol.17
, pp. 505-512
-
-
Wallace, P.M.1
Senter, P.D.2
-
76
-
-
0026250463
-
Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates
-
Senter, P.D., Su, P.C., Katsuragi, T. et al. Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates. Bioconj Chem 1991, 2: 447-51.
-
(1991)
Bioconj Chem
, vol.2
, pp. 447-451
-
-
Senter, P.D.1
Su, P.C.2
Katsuragi, T.3
-
77
-
-
0026745562
-
The bioactivation of 5-(aziridin-l-yl)-2,4-dinitrobenzamide(CB 1954) I. Purification and properties of a nitroreductase enzyme from Escherichia coli - A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
-
Anlezark, G.M., Melton, R.G., Sherwood, R.F., Coles, B., Freidlos, F., Knox, R.J. The bioactivation of 5-(aziridin-l-yl)-2,4-dinitrobenzamide(CB 1954) I. Purification and properties of a nitroreductase enzyme from Escherichia coli - a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). Biochem Pharmacol 1992, 44: 2289-95.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 2289-2295
-
-
Anlezark, G.M.1
Melton, R.G.2
Sherwood, R.F.3
Coles, B.4
Freidlos, F.5
Knox, R.J.6
-
78
-
-
0026713627
-
Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system
-
Freidlos, F., Knox, R.J. Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system. Biochem Pharmacol 1992, 44: 631-5.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 631-635
-
-
Freidlos, F.1
Knox, R.J.2
-
79
-
-
0026773434
-
Identification of novel reduced pyridinium derivatives as synthetic cofactors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)
-
Freidlos, F., Jarman, M., Davies, L.C., Boland, M.P., Knox, R.J. Identification of novel reduced pyridinium derivatives as synthetic cofactors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2). Biochem Pharmacol 1992, 44: 25-31.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 25-31
-
-
Freidlos, F.1
Jarman, M.2
Davies, L.C.3
Boland, M.P.4
Knox, R.J.5
-
80
-
-
0029009389
-
Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT)
-
Knox, R.J., Freidlos, F., Jarman, M. et al. Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT). Biochem Pharmacol 1995, 49: 1641-7.
-
(1995)
Biochem Pharmacol
, vol.49
, pp. 1641-1647
-
-
Knox, R.J.1
Freidlos, F.2
Jarman, M.3
-
81
-
-
0026677838
-
The bioactivation of 5-(aziridinl-yl)-2,4-dinitrobenzamide (CB 1954) II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase
-
Knox, R.J., Freidlos, F., Sherwood, R.F., Melton, R.G., Anlezark, G.M. The bioactivation of 5-(aziridinl-yl)-2,4-dinitrobenzamide (CB 1954) II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase. Biochem Pharmacol 1992, 44: 2297-301.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 2297-2301
-
-
Knox, R.J.1
Freidlos, F.2
Sherwood, R.F.3
Melton, R.G.4
Anlezark, G.M.5
-
82
-
-
0026665360
-
Hypoxiaselective antitumour agents. 5. Synthesis of water soluble nitroaniline mustards with selective toxicity to hypoxic mammalian cells
-
Palmer, B.P., Wilson, W.R., Cliffe, S., Denny, W.A. Hypoxiaselective antitumour agents. 5. Synthesis of water soluble nitroaniline mustards with selective toxicity to hypoxic mammalian cells. J Med Chem 1992, 35: 3214-22.
-
(1992)
J Med Chem
, vol.35
, pp. 3214-3222
-
-
Palmer, B.P.1
Wilson, W.R.2
Cliffe, S.3
Denny, W.A.4
-
83
-
-
0028246907
-
Hypoxia-selective antitumour agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
-
Palmer, B.P., Wilson, W.R., Atwell, G.J., Schultz, D., Xu, X.Z., Denny, W.A. Hypoxia-selective antitumour agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. J Med Chem 1994, 37: 2175-84.
-
(1994)
J Med Chem
, vol.37
, pp. 2175-2184
-
-
Palmer, B.P.1
Wilson, W.R.2
Atwell, G.J.3
Schultz, D.4
Xu, X.Z.5
Denny, W.A.6
-
84
-
-
0029147264
-
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase
-
Anlezark, G.M., Mellon, R.G., Sherwood, R.F. et al. Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase. Biochem Pharmacol 1995, 50: 609-18.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 609-618
-
-
Anlezark, G.M.1
Mellon, R.G.2
Sherwood, R.F.3
-
85
-
-
0028793511
-
A novel enediyne prodrug for antibody-directed enzyme prodrug therapy (ADEPT) using E. coli B nitroreductase
-
Hay, M.P., Wilson, W.R., Denny, W.A. A novel enediyne prodrug for antibody-directed enzyme prodrug therapy (ADEPT) using E. coli B nitroreductase. Bioorg Med Chem Lett 1995, 5: 2829-34.
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 2829-2834
-
-
Hay, M.P.1
Wilson, W.R.2
Denny, W.A.3
-
87
-
-
33751554864
-
Catalytic antibodies
-
Schultz, P.G., Lemer, R.A., Benkovic, S.J. Catalytic antibodies. Chem Eng News 1990, May 28: 26-40.
-
(1990)
Chem Eng News
, vol.MAY 28
, pp. 26-40
-
-
Schultz, P.G.1
Lemer, R.A.2
Benkovic, S.J.3
-
88
-
-
0028076759
-
Antibody-catalyzed prodrug activation
-
Campbell, D.A., Gong, B., Kochsperger, L.M., Yonkovich, S., Gallop, M.A., Schultz, P.G. Antibody-catalyzed prodrug activation. J Amer Chem Soc 1994, 116: 2165-6.
-
(1994)
J Amer Chem Soc
, vol.116
, pp. 2165-2166
-
-
Campbell, D.A.1
Gong, B.2
Kochsperger, L.M.3
Yonkovich, S.4
Gallop, M.A.5
Schultz, P.G.6
-
89
-
-
0026569992
-
Molecular and functional characterization of a fusion protein suited for tumour specific prodrug activation
-
Bosslet, K., Czech, J., Lorenz, P., Sedlacek, H.H., Schuermann, M., Seeman, G., Molecular and functional characterization of a fusion protein suited for tumour specific prodrug activation. Brit J Cancer 1992, 65: 234-8.
-
(1992)
Brit J Cancer
, vol.65
, pp. 234-238
-
-
Bosslet, K.1
Czech, J.2
Lorenz, P.3
Sedlacek, H.H.4
Schuermann, M.5
Seeman, G.6
-
90
-
-
0028348376
-
Tumor-selective prodrug activation by fusion protein-mediated catalysis
-
Bosslet, K., Czech, J., Hoffmann, D. Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res 1994, 54: 2151-9.
-
(1994)
Cancer Res
, vol.54
, pp. 2151-2159
-
-
Bosslet, K.1
Czech, J.2
Hoffmann, D.3
-
91
-
-
0028721102
-
Fusion protein mediated prodrug activation (FMPA) in vivo
-
Bosslet, K., Czech, J., Seeman, G., Monneret, C., Hoffmann, D. Fusion protein mediated prodrug activation (FMPA) in vivo. Cell Biophys 1994, 24/25: 51-63.
-
(1994)
Cell Biophys
, vol.24-25
, pp. 51-63
-
-
Bosslet, K.1
Czech, J.2
Seeman, G.3
Monneret, C.4
Hoffmann, D.5
-
92
-
-
10544254422
-
-
Bristol-Myers Co. EP 484870A2
-
Bristol-Myers Co. EP 484870A2.
-
-
-
|