P2X4 purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts

Journal of Cell Science

Volumn 112, Issue 23, 1999, Pages 4425-4435

  Naemsch, Lin N ^a   Weidema, A Frederik ^a,b   Sims, Stephen M ^a   Underhill, T Michael ^a   Dixon, S Jeffrey ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Extracellular nucleotide; Ion channel; Osteoclast; P2X purinoceptor; Purinergic receptor

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CIBACRON BLUE F3GA; DNA FRAGMENT; NUCLEOTIDE; OLIGONUCLEOTIDE; POTASSIUM ION; PURINE P2X RECEPTOR; SURAMIN; URIDINE TRIPHOSPHATE; ZINC ION;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CATION TRANSPORT; DEPOLARIZATION; DNA LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CONSERVED SEQUENCE; DNA PRIMERS; GENE LIBRARY; ION CHANNELS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; OSTEOCLASTS; POLYMERASE CHAIN REACTION; RABBITS; RATS; RECEPTORS, PURINERGIC P2; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033491119     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Al-Awqati, Q. (1995). Regulation of ion channels by ABC transporters that secrete ATP. Science 269, 805-806.
2. Born, G. V. and Kratzer, M. A. (1984). Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man. J. Physiol. (Lond.) 354, 419-429.
3. 2U purinoceptor present in osteoclastoma, bone, and osteoblasts. J. Bone Min. Res. 10, 1137-1145.
4. Bowler, W. B., Littlewood-Evans, A., Bilbe, G., Gallagher, J. A. and Dixon, C. J. (1998). P2Y2 receptors are expressed hy human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption. Bone 22, 195-200.
5. Brake, A. J., Wagenbach, M. J. and Julius, D. (1994). New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371, 519-523.
6. Buell, G., Lewis, C., Collo, G., North, R. A. and Surprenant, A. (1996). An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J. 15, 55-62.
7. Burnstock, G. (1997). The past, present and future of purine nucleotides as signalling molecules. Neuropharmacolgy 36, 1127-1139.
8. Chambers, T. J. and Magnus, C. J. (1982). Calcitonin alters behaviour of isolated osteoclasts. J. Pathol. 136, 27-39.
9. Chen, C. C., Akopian, A. N., Sivilotti, L., Colquhoun, D., Burnstock, G. and Wood, J. N. (1995). A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377, 428-431.
10. 2+ potentiates ATP-activated currents in rat sympathetic neurons. Pflügers Arch. 424, 152-158.
11. 6, receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16, 2495-2507.
12. 4 receptor reveals pharmacological differences to the rat homologue. Mol. Pharmacol. 51, 109-118.
13. Grygorezyk, R. and Hanrahan, J. W. (1997). CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli, Am. J. Physiol. 272, C1058-C1066.
14. Heymann, D., Guicheux, J., Gouin, F., Passuti, N. and Daculsi, G. (1998). Cytokines, growth factors and osteoclasts. Cytokine 10, 155-168.
15. Kelly, M. E., Dixon, S. J. and Sims, S. M. (1992). Inwardly rectifying potassium current in rabbit osteoclasis: a whole-cell and single-channel study, J. Membr. Biol. 126, 171-181.
16. Khakh, B. S., Bao, X. R., Labarca, C. and Lester, H. A. (1999). Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat. Neurosci. 2, 322-330.
17. 3 receptor. Neuroreport 8, 1099-1102.
18. Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H. L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., Khoo, W., Wakeham, A., Dunstan, C. R., Lacey, D. L., Mak, T. W., Boyle, W. J. and Penninger, J. M. (1999). OPGL is a key regulator of osteoclastogenesis. lymphocyte development and lymph-node organogenesis. Nature 397, 315-323.
19. Lazarowski, E. R., Homolya, L., Boucher, R. C. and Harden, T. K. (1997). Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotidc receptor activation. J. Biol. Chem. 272, 24348-24354.
20. 3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377, 432-435.
21. 2+ potentiates excitatory action of ATP on mammalian neurons. Proc. Natl. Acad. Sci. USA 90, 8264-8267.
22. Mangham, D. C., Cannon, A., Komiya, S., Gendron, R. L., Dunussi, K., Gebhardt, M. C., Mankin, H. J. and Arceci, R. J. (1996). P-alycoprotein is expressed in the mineralizing regions of the skeleton. Calcif. Tissue Int. 58, 186-191.
23. Maniatis, T., Kritsch, E. F. and Sambrook, J. (1982). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor. N.Y.: Cold Spring Harbor.
24. 4 receptor. Neuropharmacologt 37, 1579-1 1586.
25. 4-: elimination of osteoclasts, macrophages, and their precursors from isolated bone cell populations and fetal bone rudiments, Calcif. Tissue Int. 55, 141-150.
26. Morrison, M. S., Turin, L., King, B. F., Burnstock, G. and Arnett, T. R. (1998). ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J. Physiol. (Lond.) 511, 495-500.
27. 3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J. 17, 3016-3028.
28. North, R. A. and Barnard, E. A. (1997). Nucleotide receptors, Curr. Opin. Neurobiol. 7, 346-357.
29. 3 receptors. J. Neurosci. 17, 6529-6533.
30. Ralevic, V. and Burnstock, G. (1998). Receptors for purities and pyrimidines. Pharmacol. Rev. 50, 413-492.
31. 7, Cloning and expression of a human cDNA. J. Biol. Chem. 272, 5482-5486.
32. Sakai, D., Tong, H. S. and Minkin, C. (1995). Osteoclast molecular phenotyping by random cDNA sequencing. Bone 17, 111-119.
33. Seguela, P., Haghighi, A., Soghoninnian, J. J. and Cooper, K. (1996). A novel neuronal P2X ATP receptor ion channel with widespread distribution in the brain. J. Neurosci. 16, 448-455.
34. Shifnian, M. I. and Stein, D. G. (1195). A reliable and sensitive method for non-radioactive northern blot analysis of nerve growth factor mRNA from brain tissues. J. Neurosci. Methods 59, 205-208.
35. Soto, F., Lamhrecht, G., Nickel, P., Stuhmer, W. and Busch, A. E. (1990). Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38, 141-149.
36. 4: an ATP-activated ionotropic receptor cloned from rat brain. Proc: Natl. Acad. Sci. USA 93, 3684-3688.
37. Suda, T., Nakamura, I., Jimi, E. and Takahashi, N. (1997). Regulation of osteoclast function. J. Bone Min. Res. 12, 869-879.
38. Sun, X. P. and Stanley, E. F. (1996). An ATP-activated, ligand-gated ion channel on a cholinergic presynaptic nerve terminal Proc. Natl. Acad. Sci. USA 93, 1859-1863.
39. 7). Science 272, 735-738.
40. Terao, M., Studer, M., Gianni, M. and Garattini, E. (1990). Isolation and characterization of the mouse liver/bone/kidney-type alkaline phosphatase gene. Biochem. J. 268, 641-648.
41. Tezuka, K., Sato, T., Kamioka, H., Nijweide, P. J., Tanaka, K., Matsuo, T., Ohta, M., Kurihara, N., Hakeda, Y. and Kumegawa, M. (1992). Identitication of osteopontin in isolated rabbit osteoclasts. Biochem. Biophys. Res. Commun. 186, 911-917.
42. Tong, H. S., Sakai, D. D., Sims, S. M., Dixon, S. J., Yamin, M., Goldring, S. R., Snead, M. L. and Minkin, C. (1994). Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA phenotyping. J. Bone Min. Res. 9, 577-584.
43. Valera, S., Hussy, N., Evans, R. J., Adami, N., North, R. A., Surprenant, A. and Buell, G. (1994). A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature 371, 516-519.
44. 7 receptor. Neuropharmacolgy 36, 1285-1294.
45. Virginio, C., MacKenzie, A., Rasscendren, F. A., North, R. A. and Surprenant, A. (1999). Pore dilation of neuronal P2X receptor channels. Nat. Neurosci. 2, 315-321.
46. + channels in rat osteoclasts. J. Physiol. (Lond.) 503, 303-315.
47. Wiebe, S. H., Hafezi, M., Sandhu, H. S., Sims, S. M. and Dixon, S. J. (1996). Osteoclast activation in inflammatory pcriodontal diseases. Oral Dis. 2, 167-180.
48. Wiebe, S. H., Sims, S. M. and Dixon, S. J. (1999). Calcium signalling via multiple P2 purinoceptor subtypes in rat osteoclasts. Cell. Physiol. Biochem. 9, 323-337.
49. 4 receptors by extracellular pH and zinc. Br. J. Pharmacol. 126, 762-768.
50. Yu, H. and Ferrier, J. (1993). ATP induces an intracellular calcium pulse in osteoclasts. Biochem. Biophys. Res. Commun. 191, 357-363.
51. 2+ signaling in osteoclasts. Cell Signal. 6, 905-914.