P2Y2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption

Bone

Volumn 22, Issue 3, 1998, Pages 195-200

  Bowler, W B ^a   Littlewood Evans, A ^b   Bilbe, G ^b   Gallagher, J A ^a   Dixon, C J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; INOSITOL 1,4,5 TRISPHOSPHATE; NICKEL; PURINE P2Y RECEPTOR; URIDINE TRIPHOSPHATE;

ARTICLE; BONE TUMOR; CALCIUM TRANSPORT; GIANT CELL TUMOR; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS;

ADENOSINE TRIPHOSPHATE; AFFINITY LABELS; BONE NEOPLASMS; BONE RESORPTION; CALCIUM; CYTOSOL; GIANT CELL TUMOR OF BONE; HUMANS; IN SITU HYBRIDIZATION; NICKEL; OSTEOCLASTS; RECEPTORS, PURINERGIC P2; TUMOR CELLS, CULTURED; URIDINE TRIPHOSPHATE;

EID: 0032031288     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00280-9     Document Type: Article

References (24)

1. 2 purinoceptors-from molecular-biology to functional responses. Trends Pharmacol Sci 16:133-139; 1995.
2. 2u purinoceptor present in osteoclastoma, bone, and osteoblasts. J Bone Miner Res 10:1137-1145; 1995.
3. 3. Bowler, W. B., Dixon, C. J., Halleux, C., Hipskind, R. A., Fraser, W. D., Bilbe, G., and Gallagher, J. A. PTH and extracellular nucleotides synergistically induce c-fos expression in osteoblasts via distinct signal transduction pathways. J Bone Miner Res 11:46; 1996.
4. 4. Bowler, W. B. and Gallagher, J. A. Extracellular nucleotides enhance parathyroid hormone-stimulated bone resorption. J Bone Miner Res 11:22; 1996.
5. 5. DiVirgilio, F., Ferrari, D., Chiozzi, P., Falzoni, S., Sanz, J. M., dalSusino, M., Mutini, C., Hanau, S., and Baricordi, O. R. Purinoceptor function in the immune system. Drug Dev Res 39:319-329; 1996.
6. 6. Dixon, C. J., Bowler, W. B., Fleetwood, P., Ginty, A. F., Gallagher, J. A., and Carron, J. A. Extracellular nucleotides stimulate proliferation in MCF-7 breast cancer cells via P2-purinoceptors. Br J Cancer 75:34-39; 1997.
7. 7. Dixon, C. J., Bowler, W. B., Walsh, C. A., and Gallagher, J. A. Effects of extracellular nucleotides on single cells and populations of human osteoblasts: Contribution of cell heterogeneity to relative potencies. Brit J Pharmacol 120:777-780; 1997.
8. 8. Gallagher, J. A. Human bone remodeling. In: Dulbecco, R., Ed. Encyclopedia of Human Biology, Vol. 1. San Diego. CA: Academic; 1991; 811-824.
9. 2 purinergic receptors: Subtype-associated signaling responses and structure. Annu Rev Pharmacol Toxicol 35:541-579; 1995.
10. 10. Harden, T. K., Lazarowski, E. R., and Boucher, R. C. Release, metabolism, and interconversion of adenine and uridine nucleotides: Implications for G-protein-coupled P2 receptor agonist selectivity. T.i.P.S. 18:43-46; 1997.
11. 11. Kano, J., Sugimoto, T., Kanatani, M. Kuroki, Y., Tsukamoto, T., Fukase, M., and Chihara, K. Second messenger signaling of c-fos gene induction by parathyroid-hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells - Its role in osteoblast proliferation and osteoclast-like cell formation. J Cell Physiol 16:358-366; 1994.
12. 2+, but not cyclic adenosine-3′, 5′-monophosphate response to parathyroid-hormone in rat osteoblastic cells. Endocrinology 136:1674-1685; 1995.
13. 13. Littlewood-Evans, A., Kokubo, T., Ishibashi, O., Inoaka, T., Wlodarski B., Gallagher, J. A., and Bilbe, G. Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Bone 20:81-86; 1997.
14. 14. MacDonald, B. R. and Gowen, M. Cytokines and bone. Br J Rheumatol 31:149-155; 1992.
15. 15. McSheehy, P. M. J. and Chambers, T. J. Osteoblastic cells mediate osteoclastic responsiveness to parathyroid-hormone. Endocrinology 118:824-828; 1986.
16. 4+ : Elimination of osteoclasts, macrophages, and their precursors from isolated bone populations and fetal bone rudiments. Calcif Tissue Int 55:141-150; 1994.
17. 17. Pillia, S. and Bikle, D. D. Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes. J Clin Invest 90:42-51; 1992.
18. i in rat osteoblastic cells by interaction with 2 receptor subtypes. Am J Physiol 263:C1040-C1048; 1992.
19. 2+ redistribution, and divalent cation modulation. J Cell Physiol 155:120-129; 1993.
20. 2 purinoceptors on human osteoblastlike cells. J Bone Miner Res 7:485-491; 1992.
21. 7). Science 272:735-737; 1996.
22. 22. Walsh, C. A., Beresford, J. N., Birch, M. A., Boothroyd, B., and Gallagher, J. A. Application of reflected light-microscopy to identify and quantitate resorption by isolated osteoclasts. J Bone Miner Res 6:661-671; 1991.
23. 23. Yu, H. S. and Ferrier, J. ATP induces an intracellular calcium pulse in osteoclasts. Biochem Biophys Res Commun 191:357-363; 1993.
24. 2+ signaling in osteoclasts. Cell Signal 6:905-914; 1994.