P-glycoprotein is expressed in the mineralizing regions of the skeleton

Calcified Tissue International

Volumn 58, Issue 3, 1996, Pages 186-191

  Mangham, D C ^a,c   Cannon, A ^a   Komiya, S ^a   Gendron, R L ^b   Dunussi, K ^b   Gebhardt, M C ^a   Mankin, H J ^a   Arceci, R J ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Bone; Cartilage; Growth plate; P glycoprotein

Indexed keywords

CHLORIDE CHANNEL; GLYCOPROTEIN P;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; EXTRACELLULAR MATRIX; GROWTH PLATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRABECULAR BONE;

EID: 0029897694     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02526885     Document Type: Article

References (29)

1. Nooter K, Sonneveld P, Janssen A, Oostrum R, Boersma T, Herweijer H, Valerio D, Hagemeijer A, Baas F (1990) Expression of the mdr3 gene in prolymphocytic leukemia: association with cyclosporin-A-induced increase in drug accumulation. Int J Cancer 45:626-631
2. Herweijer H, Sonneveld P, Baas F, Nooter K (1990) Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. J Natl Cancer Inst 82: 1133-1140
3. Chen C, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (p-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381-389
4. van der Bliek AM, Kooiman PM, Schneider C, Borst P (1988) Sequence of mdr3 cDNA encoding a human p-glycoprotein. Gene 71:401-411
5. Higgins CF (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67-113
6. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR (1989) Multidrug-resistance gene (p-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86:695-698
7. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR (1990) Expression of the multidrug resistance gene product (p-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38:1277-1287
8. van Kalken CK, Giaccone G, van der Valk P, Kuiper CM, Hadisaputro MMN, Bosma SAA, Scheper RJ, Meijer CJLM, Pinedo HM (1992) Multidrug resistance gene (p-glycoprotein) expression in the human fetus. Am J Pathol 141:1063-1072
9. Sugawara I, Kataoka I, Morishita Y, Hamada H, Tsuruo T, Itoyama S, Mon S (1988) Tissue distribution of p-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res 48:1926-1929
10. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC (1987) Cellular localization of the multidrug-resistance gene product p-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84:7735-7738
11. Fojo A, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I (1987) Expression of a multidrug-resistant gene in human tumors and tissues. Proc Natl Acad Sci USA 84:265-269
12. Chin JE, Soffir R, Noonan KE, Choi K, Roninson IB (1989) Structure and expression of the human MDR (p-glycoprotein) gene family. Mol Cell Biol 9:3808-3820
13. van der Valk P, van Kalken CK, Ketelaars H, Broxterman HJ, Scheffer G, Kuiper CM, Tsuruo T, Lankelma J, Meijer CJLM, Pinedo HM, Scheper RJ (1990) Distribution of multi-drug resistance-associated p-glycoprotein in normal and neoplastic human tissues. Ann Oncol 1:56-64
14. Arceci RJ, Croop JM, Horwitz SB, Hausman D (1988) The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci USA 85:4350-4354
15. Rosier R, Hicks D, Fox E, Nester T, O'Keefe R, deMesy Jensen K, Reynolds P, Puzas JE (1994) Constitutive expression p-glycoprotein in chondrosarcoma may explain chemotherapeutic resistance. Transactions of the 40th Annual Meeting of the Orthopaedic Research Society 19:252
16. Ichikawa-Haraguchi M, Sumizawa T, Yoshimura A, Furukawa T; Hiramoto S, Sugita M, Akiyama S (1993) Progesterone and its metabolites: the potent inhibitors of the transporting activity of p-glycoprotein in the adrenal gland. Biochim Biophys Acta 1158:201-208
17. Valverde MA, Diaz M, Sepulveda FV (1992) Volume-regulated chloride channels associated with the human multidrug-resistance p-glycoprotein. Nature 355:830-833
18. Gill DR, Hyde SC, Higgins CF, Valverde MA, Mintenig GM, Sepulveda FV (1992) Separation of drug transport and chloride channel functions of the human multidrug resistance p-glycoprotein. Cell 71:23-32
19. Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E, van Deemter L, Mol CAAM, Ottenhoff R, van der Lugt NMT, van Roon MA, van der Valk MA, Offerhaus GJA, Berns AJM, Borst P (1993) Homozygous disruption of the murine mdr2 p-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75:451-462
20. Nonnan KE, Beck C, Holzmayer TA, Chin JE, Wunder JS, Andrulis IL, Gazdar AF, Willman CL, Griffith B, Von Hoff DD, Roninson IB (1990) Quantitative analysis of MDR1 (multidrug resistance) gene in human tumors by polymerase chain reaction. Proc Natl Acad Sci USA 87:7160-7164
21. Lincke CR, van der Bliek AM, Schuurhuis GJ, van der Velde Koerts T, Smit JJ, Borst P (1990) Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA. Cancer Res 50: 1779-1785
22. Mukai K, Yoshimura S, Anzai M (1986) Effects of decalcification on immunoperoxidase staining. Am J Surg Pathol 10:413-419
23. Devaney K, Tuyetoa NV, Sweet DE (1993) Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. Human Pathol 24:1211-1255
24. Kartner N, Evemden-Porelle D, Bradley G, Ling V (1985) Detection of p-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316:820-823
25. Georges E, Bradley G, Gariepy J, Ling V (1990) Detection of p-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc Natl Acad Sci USA 87:152-156
26. Schinkel AH, Roelofs MEM, Borst P (1991) Characterization of the human MDR3 p-glycoprotein-specific monoclonal antibodies. Cancer Res 51:2628-2635
27. Anderson HC (1969) Vesicles associated with calcification in the matrix of epiphyseal cartilage. J Cell Biol 41:59-72
28. Anderson HC (1989) Biology of disease: mechanism of mineral formation in bone. Lab Invest 60:320-330
29. Abraham EH, Prat AG, Gerweck L, Seneveratne T, Arceci RJ, Kramer R, Guidotti G, Cantiello HF (1993) The multidrug-resistant (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci USA. 90:31-316