메뉴 건너뛰기




Volumn 45, Issue 12, 1996, Pages 1774-1782

Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β-cells

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN; INSULIN; PROTEIN;

EID: 0029859966     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.12.1774     Document Type: Article
Times cited : (104)

References (44)
  • 1
  • 2
    • 0024351557 scopus 로고
    • Type II diabetes, glucose "non-sense," and islet desensitization
    • Robertson RP: Type II diabetes, glucose "non-sense," and islet desensitization. Diabetes 38:1501-1505, 1989
    • (1989) Diabetes , vol.38 , pp. 1501-1505
    • Robertson, R.P.1
  • 3
    • 0002678511 scopus 로고
    • Pathogenesis of non-insulin-dependent (type II) diabetes mellitus
    • Hahn CR, Weir GC, Eds. Philadelphia, Lea & Febiger
    • Weir GC, Leahy JL: Pathogenesis of non-insulin-dependent (type II) diabetes mellitus. In Joslin's Diabetes Mellitus. 13th ed. Hahn CR, Weir GC, Eds. Philadelphia, Lea & Febiger, 1994, p. 240-264
    • (1994) Joslin's Diabetes Mellitus 13th Ed. , pp. 240-264
    • Weir, G.C.1    Leahy, J.L.2
  • 5
    • 0021220641 scopus 로고
    • Abnormal glucose regulation of insulin secretion in models of reduced β-cell mass
    • Leahy JL, Bonner-Weir S, Weir GC: Abnormal glucose regulation of insulin secretion in models of reduced β-cell mass. Diabetes 33:667-673, 1984
    • (1984) Diabetes , vol.33 , pp. 667-673
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 6
    • 0022522943 scopus 로고
    • Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: A study in normal rats using chronic in vivo glucose infusions
    • Leahy JL, Cooper HE, Deal DA, Weir GC: Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: a study in normal rats using chronic in vivo glucose infusions. J Clin Invest 77:908-915, 1986
    • (1986) J Clin Invest , vol.77 , pp. 908-915
    • Leahy, J.L.1    Cooper, H.E.2    Deal, D.A.3    Weir, G.C.4
  • 7
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • Bonner-Weir S, Trent DF, Weir GC: Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 71:1544-1553, 1983
    • (1983) J Clin Invest , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 8
    • 0026511753 scopus 로고
    • β-cell dysfunction induced by chronic hyperglycemia: Current ideas on mechanism of impaired glucose- Induced insulin secretion
    • Leahy JL, Bonner-Weir S, Weir GC: β-cell dysfunction induced by chronic hyperglycemia: current ideas on mechanism of impaired glucose- induced insulin secretion. Diabetes Care 15:442-455, 1992
    • (1992) Diabetes Care , vol.15 , pp. 442-455
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 9
    • 0025600472 scopus 로고
    • Hyperglycemia-induced β-cell toxicity: The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background
    • Korsgren O, Jansson L, Sandler S, Andersson A: Hyperglycemia-induced β-cell toxicity: the fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J Clin Invest 86:2161-2168, 1990
    • (1990) J Clin Invest , vol.86 , pp. 2161-2168
    • Korsgren, O.1    Jansson, L.2    Sandler, S.3    Andersson, A.4
  • 10
    • 0026451942 scopus 로고
    • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β- Cell function
    • Eizirik DL, Korbutt GS, Hellerström C: Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β- cell function. J Clin Invest 90:1263-1268, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1263-1268
    • Eizirik, D.L.1    Korbutt, G.S.2    Hellerström, C.3
  • 11
    • 0023947320 scopus 로고
    • Characteristics of desensitization of insulin secretion in fully in vitro system
    • Bolaffi JL, Bruno L, Heldt A, Grodsky GM: Characteristics of desensitization of insulin secretion in fully in vitro system. Endocrinology 122:1801-1809, 1988
    • (1988) Endocrinology , vol.122 , pp. 1801-1809
    • Bolaffi, J.L.1    Bruno, L.2    Heldt, A.3    Grodsky, G.M.4
  • 12
    • 0026607455 scopus 로고
    • Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: Evidence supporting specific desensitization rather than β-cell exhaustion
    • Davalli AM, Pontiroli AE, Socci C, Bertuzzi F, Fattor B, Braghi S, Di Carlo V, Pozza G: Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than β-cell exhaustion. J Clin Endocrine Metab 74:790-794, 1992
    • (1992) J Clin Endocrine Metab , vol.74 , pp. 790-794
    • Davalli, A.M.1    Pontiroli, A.E.2    Socci, C.3    Bertuzzi, F.4    Fattor, B.5    Braghi, S.6    Di Carlo, V.7    Pozza, G.8
  • 13
    • 0024451490 scopus 로고
    • Effects of high glucose on insulin secretion by isolated rat islets and purified β-cells and possible role of glycosylation
    • Purrello F, Vetri M, Gatta C, Gullo D, Vigneri R: Effects of high glucose on insulin secretion by isolated rat islets and purified β-cells and possible role of glycosylation. Diabetes 38:1417-1422, 1989
    • (1989) Diabetes , vol.38 , pp. 1417-1422
    • Purrello, F.1    Vetri, M.2    Gatta, C.3    Gullo, D.4    Vigneri, R.5
  • 14
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou Y-P, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.-P.1    Grill, V.E.2
  • 16
    • 0028318109 scopus 로고
    • Preservation of glucose-responsive islet beta cells during serum-free culture
    • Ling Z, Pipeleers DG: Preservation of glucose-responsive islet beta cells during serum-free culture. Endocrinology 134:2614-2621, 1994
    • (1994) Endocrinology , vol.134 , pp. 2614-2621
    • Ling, Z.1    Pipeleers, D.G.2
  • 17
    • 0026651708 scopus 로고
    • Heterogeneity in pancreatic β-cell population
    • Pipeleers D: Heterogeneity in pancreatic β-cell population. Diabetes 41:777-781, 1992
    • (1992) Diabetes , vol.41 , pp. 777-781
    • Pipeleers, D.1
  • 18
    • 0028095283 scopus 로고
    • Physiologic relevance of heterogeneity in pancreatic β-cell population
    • Pipeleers D, Kiekens R, Ling Z, Wilikens A, Schuit F: Physiologic relevance of heterogeneity in pancreatic β-cell population. Diabetologia 37 (Suppl. 2):S57-S64, 1994
    • (1994) Diabetologia , vol.37 , Issue.2 SUPPL.
    • Pipeleers, D.1    Kiekens, R.2    Ling, Z.3    Wilikens, A.4    Schuit, F.5
  • 19
    • 0039829851 scopus 로고
    • Glucose stimulated proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
    • Schuit FC, In't Veld PA, Pipeleers DG: Glucose stimulated proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci USA 85:3865-3869, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 20
    • 0026593276 scopus 로고
    • Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity
    • Kiekens R, In't Veld PA, Mahler T, Schuit FC, Van De Winkel M, Pipeleers DG: Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity. J Clin Invest 89:117-125, 1991
    • (1991) J Clin Invest , vol.89 , pp. 117-125
    • Kiekens, R.1    In't Veld, P.A.2    Mahler, T.3    Schuit, F.C.4    Van de Winkel, M.5    Pipeleers, D.G.6
  • 22
    • 0028084965 scopus 로고
    • Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
    • Ling Z, Hannaert JC, Pipeleers D: Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture. Diabetologia 37:15-21, 1994
    • (1994) Diabetologia , vol.37 , pp. 15-21
    • Ling, Z.1    Hannaert, J.C.2    Pipeleers, D.3
  • 23
    • 0026666964 scopus 로고
    • Possible role of glycogen accumu- Lation in β-cell glucotoxicity
    • Malaisse WJ, Marynissen G, Sener A: Possible role of glycogen accumu- lation in β-cell glucotoxicity. Metabolism 41:814-819, 1992
    • (1992) Metabolism , vol.41 , pp. 814-819
    • Malaisse, W.J.1    Marynissen, G.2    Sener, A.3
  • 24
    • 0025324515 scopus 로고
    • A sensitive radioisotopic method for the measurement of NAD(P)H: Its application to assay of metabolites and enzymatic activities
    • Sener A, Malaisse, WJ: A sensitive radioisotopic method for the measurement of NAD(P)H: its application to assay of metabolites and enzymatic activities. Anal Biochem 186:236-242, 1990
    • (1990) Anal Biochem , vol.186 , pp. 236-242
    • Sener, A.1    Malaisse, W.J.2
  • 25
    • 0020513514 scopus 로고
    • Autofluorescence-activated cell sorting of pancreatic islet cells: Purification of insulin-containing β-cells according to glucose-induced changes in cellular redox state
    • Van De Winkel M, Pipeleers DG: Autofluorescence-activated cell sorting of pancreatic islet cells: purification of insulin-containing β-cells according to glucose-induced changes in cellular redox state. Biochem Biophys Res Commun 114:835-842, 1983
    • (1983) Biochem Biophys Res Commun , vol.114 , pp. 835-842
    • Van de Winkel, M.1    Pipeleers, D.G.2
  • 26
    • 0025077507 scopus 로고
    • Direct effect of insulin and insulin-like growth factor-I on the secretory activity of rat pancreatic beta cells
    • Van Schravendijk C, Heylen L, Van den Brande JL, Pipeleers D: Direct effect of insulin and insulin-like growth factor-I on the secretory activity of rat pancreatic beta cells. Diabetologia 33:649-653, 1990
    • (1990) Diabetologia , vol.33 , pp. 649-653
    • Van Schravendijk, C.1    Heylen, L.2    Van den Brande, J.L.3    Pipeleers, D.4
  • 27
    • 0027203345 scopus 로고
    • Heterogeneity in glucose sensitivity among pancreatic β- Cells is correlated to differences in glucose phosphorylation rather than glucose transport
    • Heimberg H, De Vos A, Vandercammen A, Van Schaftingen E, Pipeleers D, Schuit F: Heterogeneity in glucose sensitivity among pancreatic β- cells is correlated to differences in glucose phosphorylation rather than glucose transport. EMBO J 12:2873-2879, 1993
    • (1993) EMBO J , vol.12 , pp. 2873-2879
    • Heimberg, H.1    De Vos, A.2    Vandercammen, A.3    Van Schaftingen, E.4    Pipeleers, D.5    Schuit, F.6
  • 28
    • 0022254988 scopus 로고
    • The insulin factory: A tour of the plant surroundings and a visit to the assembly line
    • Orci L: The insulin factory: a tour of the plant surroundings and a visit to the assembly line. Diabetologia 28:528-546, 1985
    • (1985) Diabetologia , vol.28 , pp. 528-546
    • Orci, L.1
  • 29
    • 0016354383 scopus 로고
    • Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture
    • Andersson A, Westman J, Hellerström C: Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture. Diabetologia 10:743-753, 1974
    • (1974) Diabetologia , vol.10 , pp. 743-753
    • Andersson, A.1    Westman, J.2    Hellerström, C.3
  • 30
    • 0017666506 scopus 로고
    • Specific glucose protection of pancreatic β-cell function during culture in chemically defined medium
    • Gylfe E: Specific glucose protection of pancreatic β-cell function during culture in chemically defined medium. Endocrinology 101:1281-1285, 1977
    • (1977) Endocrinology , vol.101 , pp. 1281-1285
    • Gylfe, E.1
  • 31
    • 0025825175 scopus 로고
    • Long-term effects of a high glucose concentration in vitro on the oxidative metabolism and insulin production of isolated rat pancreatic islets
    • Svensson C, Hellerström C: Long-term effects of a high glucose concentration in vitro on the oxidative metabolism and insulin production of isolated rat pancreatic islets. Metabolism 40:513-518, 1991
    • (1991) Metabolism , vol.40 , pp. 513-518
    • Svensson, C.1    Hellerström, C.2
  • 32
    • 0025083434 scopus 로고
    • Glucose regulates glucokinase activity in cultured islets from rat pancreas
    • Liang Y, Najafi H, Matschinsky FM: Glucose regulates glucokinase activity in cultured islets from rat pancreas. J Bio Chem 265:16863-16866, 1990
    • (1990) J Bio Chem , vol.265 , pp. 16863-16866
    • Liang, Y.1    Najafi, H.2    Matschinsky, F.M.3
  • 33
    • 0026625602 scopus 로고
    • Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture
    • Liang Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM: Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41:792-806, 1992
    • (1992) Diabetes , vol.41 , pp. 792-806
    • Liang, Y.1    Najafi, H.2    Smith, R.M.3    Zimmerman, E.C.4    Magnuson, M.A.5    Tal, M.6    Matschinsky, F.M.7
  • 34
    • 0027391166 scopus 로고
    • Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic β-cells
    • Purrello F, Buscema M, Rabuazzo AM, Caltabiano V, Forte F, Vinci C, Vetri M, Vigneri R: Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic β-cells. Diabetes 42:199-205, 1993
    • (1993) Diabetes , vol.42 , pp. 199-205
    • Purrello, F.1    Buscema, M.2    Rabuazzo, A.M.3    Caltabiano, V.4    Forte, F.5    Vinci, C.6    Vetri, M.7    Vigneri, R.8
  • 35
    • 0026033901 scopus 로고
    • Abnormal sensitivity to glucose of human islets cultured in a high glucose medium: Partial reversibility after an additional culture in a normal glucose medium
    • Davalli AM, Ricordi C, Socci C, Braghi S, Bertuzzi F, Fattor B, Di Carlo V, Pontiroli AE, Pozza G: Abnormal sensitivity to glucose of human islets cultured in a high glucose medium: partial reversibility after an additional culture in a normal glucose medium. J Clin Endocrinol Metab 72:202-208, 1991
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 202-208
    • Davalli, A.M.1    Ricordi, C.2    Socci, C.3    Braghi, S.4    Bertuzzi, F.5    Fattor, B.6    Di Carlo, V.7    Pontiroli, A.E.8    Pozza, G.9
  • 36
    • 0025736821 scopus 로고
    • Diabetic hyperglycemia: Link to impaired glucose transport in pancreatic β-cells
    • Unger RH: Diabetic hyperglycemia: link to impaired glucose transport in pancreatic β-cells. Science 251:1200-1205, 1991
    • (1991) Science , vol.251 , pp. 1200-1205
    • Unger, R.H.1
  • 37
    • 0026065018 scopus 로고
    • Content of CoA-esters in perifused rat islets stimulated by glucose and other fuels
    • Liang Y, Matschinsky FM: Content of CoA-esters in perifused rat islets stimulated by glucose and other fuels. Diabetes 40:327-333, 1991
    • (1991) Diabetes , vol.40 , pp. 327-333
    • Liang, Y.1    Matschinsky, F.M.2
  • 38
    • 0018643965 scopus 로고
    • Effects of glucose on the cytosolic ratio of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans
    • Ashcroft SJH, Christie MR: Effects of glucose on the cytosolic ratio of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans. Biochem J 184:697-700, 1979
    • (1979) Biochem J , vol.184 , pp. 697-700
    • Ashcroft, S.J.H.1    Christie, M.R.2
  • 39
    • 0026051640 scopus 로고
    • Measuring the balance between insulin synthesis and insulin release
    • Schuit FC, Kiekens R, Pipeleers DG: Measuring the balance between insulin synthesis and insulin release. Biochem Biophys Res Commun 178:1182-1187, 1991
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 1182-1187
    • Schuit, F.C.1    Kiekens, R.2    Pipeleers, D.G.3
  • 40
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-663, 1995
    • (1995) Diabetes , vol.14 , pp. 619-663
    • Gepts, W.1
  • 41
    • 0347240386 scopus 로고
    • Glycogen infiltration (so-called hydropic degeneration) in the pancreas in human and experimental diabetes mellitus
    • Toreson WE: Glycogen infiltration (so-called hydropic degeneration) in the pancreas in human and experimental diabetes mellitus. Am J Pathol 27:327-347, 1951
    • (1951) Am J Pathol , vol.27 , pp. 327-347
    • Toreson, W.E.1
  • 42
    • 0015959246 scopus 로고
    • Effects of glucose on the content of ATP and glycogen and the rate of glucose phosphorylation of isolated pancreatic islets maintained in tissue culture
    • Andersson A, Borglund E, Brolin S: Effects of glucose on the content of ATP and glycogen and the rate of glucose phosphorylation of isolated pancreatic islets maintained in tissue culture. Biochem Biophys Res Commun 56:1045-1051, 1974
    • (1974) Biochem Biophys Res Commun , vol.56 , pp. 1045-1051
    • Andersson, A.1    Borglund, E.2    Brolin, S.3
  • 44
    • 0027509353 scopus 로고
    • Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats
    • Malaisse WJ, Maggetto C, Leclercq-Meyer V, Sener A: Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats. J Clin Invest 91:432-436, 1993
    • (1993) J Clin Invest , vol.91 , pp. 432-436
    • Malaisse, W.J.1    Maggetto, C.2    Leclercq-Meyer, V.3    Sener, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.