-
1
-
-
0015717745
-
Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects
-
Rastogi G, Sinha MK, Dash RJ: Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects. Diabetes 22:804-807, 1973
-
(1973)
Diabetes
, vol.22
, pp. 804-807
-
-
Rastogi, G.1
Sinha, M.K.2
Dash, R.J.3
-
2
-
-
0016582510
-
Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood
-
Horwitz D, Starr JL, Mako ME, Blackard WG, Rubenstein AH: Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55:1278-1283, 1975
-
(1975)
J Clin Invest
, vol.55
, pp. 1278-1283
-
-
Horwitz, D.1
Starr, J.L.2
Mako, M.E.3
Blackard, W.G.4
Rubenstein, A.H.5
-
3
-
-
0021269443
-
The metabolic effects of biosynthetic human proinsulin in individuals with type 1 diabetes
-
Bergenstal RM, Cohen RM, Lever E, Polonsky K, Jaspan J, Blix PM, Revers R, Olefsky JM, Kolterman O, Steiner K, Cherrington A, Frank B, Galloway J, Rubenstein AH: The metabolic effects of biosynthetic human proinsulin in individuals with type 1 diabetes. J Clin Endocrinol Metab 58:973-979, 1984
-
(1984)
J Clin Endocrinol Metab
, vol.58
, pp. 973-979
-
-
Bergenstal, R.M.1
Cohen, R.M.2
Lever, E.3
Polonsky, K.4
Jaspan, J.5
Blix, P.M.6
Revers, R.7
Olefsky, J.M.8
Kolterman, O.9
Steiner, K.10
Cherrington, A.11
Frank, B.12
Galloway, J.13
Rubenstein, A.H.14
-
4
-
-
0023634652
-
Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
-
Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D: Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 30:698-702, 1987
-
(1987)
Diabetologia
, vol.30
, pp. 698-702
-
-
Ward, W.K.1
LaCava, E.C.2
Paquette, T.L.3
Beard, J.C.4
Wallum, B.J.5
Porte, D.6
-
5
-
-
0023759449
-
Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
-
Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y: Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 31:355-360, 1988
-
(1988)
Diabetologia
, vol.31
, pp. 355-360
-
-
Yoshioka, N.1
Kuzuya, T.2
Matsuda, A.3
Taniguchi, M.4
Iwamoto, Y.5
-
6
-
-
0025989824
-
Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance
-
Shiraishi I, Iwamoto Y, Kuzuya T, Matsuda A, Kumakura S: Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance. Diabetologia 34:737-741, 1991
-
(1991)
Diabetologia
, vol.34
, pp. 737-741
-
-
Shiraishi, I.1
Iwamoto, Y.2
Kuzuya, T.3
Matsuda, A.4
Kumakura, S.5
-
7
-
-
0015416775
-
Direct measurement of plasma proinsulin in normal and diabetic subjects
-
Duckworth WC, Kitabchi AE, Heinemann M: Direct measurement of plasma proinsulin in normal and diabetic subjects. Am J Med 53:418-427, 1972
-
(1972)
Am J Med
, vol.53
, pp. 418-427
-
-
Duckworth, W.C.1
Kitabchi, A.E.2
Heinemann, M.3
-
8
-
-
0016209121
-
Circulating proinsulin-like component in man: Increased proportion in hypoinsulinaemic states
-
Gorden P, Hendricks CM, Roth J: Circulating proinsulin-like component in man: increased proportion in hypoinsulinaemic states. Diabetologia 10:469-474, 1974
-
(1974)
Diabetologia
, vol.10
, pp. 469-474
-
-
Gorden, P.1
Hendricks, C.M.2
Roth, J.3
-
9
-
-
0024214959
-
Preferential release of proinsulin relative to insulin in non-insulin-dependent diabetes mellitus
-
Deacon CF, Schleser-Mohr S, Ballmann M, Willms B, Conlon JM, Creutzfeldt W: Preferential release of proinsulin relative to insulin in non-insulin-dependent diabetes mellitus. Acta Endocrinol 119:549-554, 1988
-
(1988)
Acta Endocrinol
, vol.119
, pp. 549-554
-
-
Deacon, C.F.1
Schleser-Mohr, S.2
Ballmann, M.3
Willms, B.4
Conlon, J.M.5
Creutzfeldt, W.6
-
10
-
-
0024494876
-
Insulin deficiency in non-insulin-dependent diabetes
-
Temple RC, Carrington CA, Luzio SD, Owens DR, Schneider AE, Sobey WJ, Hales CN: Insulin deficiency in non-insulin-dependent diabetes. Lancet i:293-295, 1989
-
(1989)
Lancet
, vol.1
, pp. 293-295
-
-
Temple, R.C.1
Carrington, C.A.2
Luzio, S.D.3
Owens, D.R.4
Schneider, A.E.5
Sobey, W.J.6
Hales, C.N.7
-
11
-
-
0025850898
-
Raised proinsulin concentration as early indicator of β-cell dysfunction
-
Williams DRR, Byrne C, Clark PMS, Cox L, Day NE, Rayman G, Wang T, Hales CN: Raised proinsulin concentration as early indicator of β-cell dysfunction. BMJ 303:95-96, 1991
-
(1991)
BMJ
, vol.303
, pp. 95-96
-
-
Williams, D.R.R.1
Byrne, C.2
Clark, P.M.S.3
Cox, L.4
Day, N.E.5
Rayman, G.6
Wang, T.7
Hales, C.N.8
-
12
-
-
0027251602
-
Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose intolerance
-
Davies MJ, Rayman G, Gray IP, Day JL, Hales CN: Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose intolerance. Diabet Med 10:313-320, 1993
-
(1993)
Diabet Med
, vol.10
, pp. 313-320
-
-
Davies, M.J.1
Rayman, G.2
Gray, I.P.3
Day, J.L.4
Hales, C.N.5
-
13
-
-
0025292213
-
Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics
-
Temple RC, Clark PMS, Nagi DK, Schneider AE, Yudkin JS, Hales CN: Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics. Clin Endocrinol 32:689-693, 1990
-
(1990)
Clin Endocrinol
, vol.32
, pp. 689-693
-
-
Temple, R.C.1
Clark, P.M.S.2
Nagi, D.K.3
Schneider, A.E.4
Yudkin, J.S.5
Hales, C.N.6
-
14
-
-
85036493279
-
Recently released β-cell granule constituents as an indicator of proinsulin processing in NIDDM
-
Kahn SE, Halban PA: Recently released β-cell granule constituents as an indicator of proinsulin processing in NIDDM (Abstract). Diabetologia 38 (Suppl. 1):A114, 1995
-
(1995)
Diabetologia
, vol.38
, Issue.1 SUPPL.
-
-
Kahn, S.E.1
Halban, P.A.2
-
15
-
-
0027386638
-
Normal proinsulin responses to glucose in mild type II subjects with subnormal insulin response
-
Levy JC, Clark PM, Hales CN, Turner RC: Normal proinsulin responses to glucose in mild type II subjects with subnormal insulin response. Diabetes 42:162-169, 1993
-
(1993)
Diabetes
, vol.42
, pp. 162-169
-
-
Levy, J.C.1
Clark, P.M.2
Hales, C.N.3
Turner, R.C.4
-
16
-
-
0017761172
-
Circulating proinsulin in patients with maturity onset diabetes
-
Mako ME, Starr JI, Rubenstein AH: Circulating proinsulin in patients with maturity onset diabetes. Am J Med 63:865-869, 1977
-
(1977)
Am J Med
, vol.63
, pp. 865-869
-
-
Mako, M.E.1
Starr, J.I.2
Rubenstein, A.H.3
-
17
-
-
0025268864
-
Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus
-
Saad MF, Kahn SE, Nelson RG, Pettitt DJ, Knowler WC, Schwartz MW, Kowalyk S, Bennett PH, Porte D: Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 70:1247-1253, 1990
-
(1990)
J Clin Endocrinol Metab
, vol.70
, pp. 1247-1253
-
-
Saad, M.F.1
Kahn, S.E.2
Nelson, R.G.3
Pettitt, D.J.4
Knowler, W.C.5
Schwartz, M.W.6
Kowalyk, S.7
Bennett, P.H.8
Porte, D.9
-
18
-
-
14444270617
-
Elevated intact proinsulin in NIDDM is not due to obesity
-
Roder ME, Dinesen B, Houssa P, Hartling SG, Sodoyez-Goffaux F, Binder C: Elevated intact proinsulin in NIDDM is not due to obesity (Abstract). Diabetologia 38 (Suppl. 1):A114, 1995
-
(1995)
Diabetologia
, vol.38
, Issue.1 SUPPL.
-
-
Roder, M.E.1
Dinesen, B.2
Houssa, P.3
Hartling, S.G.4
Sodoyez-Goffaux, F.5
Binder, C.6
-
19
-
-
0024271685
-
Reduction of glycemic potentiation: Sensitive indicator of β-cell loss in partially pancreatectomized dogs
-
Ward WK, Wallum BJ, Beard JC, Taborsky GJ, Porte D: Reduction of glycemic potentiation: sensitive indicator of β-cell loss in partially pancreatectomized dogs. Diabetes 37:723-729, 1988
-
(1988)
Diabetes
, vol.37
, pp. 723-729
-
-
Ward, W.K.1
Wallum, B.J.2
Beard, J.C.3
Taborsky, G.J.4
Porte, D.5
-
20
-
-
0024463227
-
Hyperproinsulinemia and amyloid in NIDDM: Clues to etiology of islet β-cell dysfunction?
-
Porte D, Kahn SE: Hyperproinsulinemia and amyloid in NIDDM: clues to etiology of islet β-cell dysfunction? Diabetes 38:1333-1336, 1989
-
(1989)
Diabetes
, vol.38
, pp. 1333-1336
-
-
Porte, D.1
Kahn, S.E.2
-
21
-
-
0024538602
-
Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance
-
Kahn SE, Beard JC, Schwartz MW, Ward WK, Lun Ding H, Bergman RN, Taborsky GJ, Porte D: Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes 38:562-568, 1989
-
(1989)
Diabetes
, vol.38
, pp. 562-568
-
-
Kahn, S.E.1
Beard, J.C.2
Schwartz, M.W.3
Ward, W.K.4
Lun Ding, H.5
Bergman, R.N.6
Taborsky, G.J.7
Porte, D.8
-
22
-
-
0027217510
-
Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans
-
Kahn SE, Horber FF, Prigeon RL, Haymond MW, Porte D: Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans. Diabetes 42:1082-1085, 1993
-
(1993)
Diabetes
, vol.42
, pp. 1082-1085
-
-
Kahn, S.E.1
Horber, F.F.2
Prigeon, R.L.3
Haymond, M.W.4
Porte, D.5
-
23
-
-
0023932360
-
Increased proinsulin levels as an early indicator of β-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients
-
Heaton DA, Millward BA, Gray IP, Tun Y, Hales CN, Pyke DA, Leslie RDG: Increased proinsulin levels as an early indicator of β-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia 31:182-184, 1988
-
(1988)
Diabetologia
, vol.31
, pp. 182-184
-
-
Heaton, D.A.1
Millward, B.A.2
Gray, I.P.3
Tun, Y.4
Hales, C.N.5
Pyke, D.A.6
Leslie, R.D.G.7
-
24
-
-
0024435846
-
Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
-
Hartling SG, Lindgren F, Dahlqvist G, Persson B, Binder C: Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 38:1271-1274, 1989
-
(1989)
Diabetes
, vol.38
, pp. 1271-1274
-
-
Hartling, S.G.1
Lindgren, F.2
Dahlqvist, G.3
Persson, B.4
Binder, C.5
-
25
-
-
0026585133
-
Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients
-
Spinas GA, Snorgaard O, Hartling SG, Oberholzer M, Berger W: Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients. Diabetes Care 15:632-637, 1992
-
(1992)
Diabetes Care
, vol.15
, pp. 632-637
-
-
Spinas, G.A.1
Snorgaard, O.2
Hartling, S.G.3
Oberholzer, M.4
Berger, W.5
-
26
-
-
0020603334
-
Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year
-
U.K. Prospective Study of Therapies of Maturity-Onset Diabetes: Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year. Diabetologia 24:404-411, 1983
-
(1983)
Diabetologia
, vol.24
, pp. 404-411
-
-
-
27
-
-
0024496341
-
Unbiased and flexible iterative computer program to achieve glucose clamping
-
Matthews DR, Hosker JP: Unbiased and flexible iterative computer program to achieve glucose clamping. Diabetes Care 12:156-159, 1989
-
(1989)
Diabetes Care
, vol.12
, pp. 156-159
-
-
Matthews, D.R.1
Hosker, J.P.2
-
28
-
-
0028364363
-
Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects
-
U.K. Prospective Diabetes Study (UKPDS) XI: Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects. Diabet Med 11:534-544, 1994
-
(1994)
Diabet Med
, vol.11
, pp. 534-544
-
-
-
29
-
-
0027499784
-
Enzyme immunoassay for intact human insulin in serum or plasma
-
Andersen L, Dinesen B, Jorgensen PN, Poulsen F, Roder ME: Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 39:578-582, 1993
-
(1993)
Clin Chem
, vol.39
, pp. 578-582
-
-
Andersen, L.1
Dinesen, B.2
Jorgensen, P.N.3
Poulsen, F.4
Roder, M.E.5
-
30
-
-
0027436630
-
Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies
-
Kjems LL, Roder ME, Dinesen B, Hartling SG, Jorgensen PN, Binder C: Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies. Clin Chem 39:2146-2150, 1993
-
(1993)
Clin Chem
, vol.39
, pp. 2146-2150
-
-
Kjems, L.L.1
Roder, M.E.2
Dinesen, B.3
Hartling, S.G.4
Jorgensen, P.N.5
Binder, C.6
-
31
-
-
0028314832
-
Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus
-
Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP: Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus. Diabet Med 11:293-298, 1994
-
(1994)
Diabet Med
, vol.11
, pp. 293-298
-
-
Davies, M.J.1
Metcalfe, J.2
Day, J.L.3
Grenfell, A.4
Hales, C.N.5
Gray, I.P.6
-
32
-
-
0029834356
-
Effect of sulfonylurea withdrawal on proinsulin levels, B cell function, and glucose disposal in subjects with non-insulin-dependent diabetes mellitus
-
Prigeon RL, Jacobson RK, Porte D, Kahn SE: Effect of sulfonylurea withdrawal on proinsulin levels, B cell function, and glucose disposal in subjects with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81:3295-3298, 1996
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 3295-3298
-
-
Prigeon, R.L.1
Jacobson, R.K.2
Porte, D.3
Kahn, S.E.4
-
33
-
-
3943110287
-
Sulphonylurea therapy stimulates basal and post glucose load levels of proinsulin
-
Mohammed-Ali V, Panahloo A, Denver E, Andres C, Yudkin JS: Sulphonylurea therapy stimulates basal and post glucose load levels of proinsulin (Abstract). Diabetologia 38 (Suppl. 1):A115, 1995
-
(1995)
Diabetologia
, vol.38
, Issue.1 SUPPL.
-
-
Mohammed-Ali, V.1
Panahloo, A.2
Denver, E.3
Andres, C.4
Yudkin, J.S.5
-
34
-
-
0003348482
-
C-peptide and proinsulin
-
Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, Eds. Chichester, Wiley
-
Madsbad S, Hartling SG, Faber OK: C-peptide and proinsulin. In International Textbook of Diabetes Mellitus. Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, Eds. Chichester, Wiley, 1992, p. 303-332
-
(1992)
International Textbook of Diabetes Mellitus
, pp. 303-332
-
-
Madsbad, S.1
Hartling, S.G.2
Faber, O.K.3
-
36
-
-
0028339912
-
Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM
-
Polonsky KS, Gumbiner B, Ostrega D, Griver K, Tager H, Henry RR: Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes 43:871-877, 1994
-
(1994)
Diabetes
, vol.43
, pp. 871-877
-
-
Polonsky, K.S.1
Gumbiner, B.2
Ostrega, D.3
Griver, K.4
Tager, H.5
Henry, R.R.6
-
37
-
-
0024493106
-
Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM
-
Yoshioka N, Kuzuya T, Matsuda A, Iwamoto Y: Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM. Diabetes 38:262-266, 1989
-
(1989)
Diabetes
, vol.38
, pp. 262-266
-
-
Yoshioka, N.1
Kuzuya, T.2
Matsuda, A.3
Iwamoto, Y.4
-
38
-
-
0028137716
-
Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus
-
Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP: Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus. Diabet Med 11:71-78, 1994
-
(1994)
Diabet Med
, vol.11
, pp. 71-78
-
-
Davies, M.J.1
Metcalfe, J.2
Day, J.L.3
Grenfell, A.4
Hales, C.N.5
Gray, I.P.6
-
39
-
-
0028230040
-
What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism
-
Rhodes CJ, Alarcon C: What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes 43:511-517, 1994
-
(1994)
Diabetes
, vol.43
, pp. 511-517
-
-
Rhodes, C.J.1
Alarcon, C.2
-
40
-
-
0028898539
-
Proinsulin as a marker for the development of NIDDM in Japanese-American men
-
Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY: Proinsulin as a marker for the development of NIDDM in Japanese-American men. Diabetes 44:173-179, 1995
-
(1995)
Diabetes
, vol.44
, pp. 173-179
-
-
Kahn, S.E.1
Leonetti, D.L.2
Prigeon, R.L.3
Boyko, E.J.4
Bergstrom, R.W.5
Fujimoto, W.Y.6
-
41
-
-
0029050206
-
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects
-
Mykkanen L, Haffner SM, Kuusisto J, Pyorala K, Hales CN, Laakso M: Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. Diabetologia 38:1176-1182, 1995
-
(1995)
Diabetologia
, vol.38
, pp. 1176-1182
-
-
Mykkanen, L.1
Haffner, S.M.2
Kuusisto, J.3
Pyorala, K.4
Hales, C.N.5
Laakso, M.6
-
42
-
-
0030045866
-
Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: The Hoorn Study
-
Nijpels G, Popp-Snijders C, Kostense PJ, Bouter LM, Heine RJ: Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia 39:113-118, 1996
-
(1996)
Diabetologia
, vol.39
, pp. 113-118
-
-
Nijpels, G.1
Popp-Snijders, C.2
Kostense, P.J.3
Bouter, L.M.4
Heine, R.J.5
|