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Volumn 46, Issue 10, 1997, Pages 1557-1562

Relative hyperproinsulinemia of NIDDM persists despite the reduction of hyperglycemia with insulin or sulfonylurea therapy

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLICLAZIDE; INSULIN; INSULIN ZINC SUSPENSION; SULFONYLUREA;

EID: 0030845937     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.46.10.1557     Document Type: Article
Times cited : (33)

References (42)
  • 1
    • 0015717745 scopus 로고
    • Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects
    • Rastogi G, Sinha MK, Dash RJ: Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects. Diabetes 22:804-807, 1973
    • (1973) Diabetes , vol.22 , pp. 804-807
    • Rastogi, G.1    Sinha, M.K.2    Dash, R.J.3
  • 2
    • 0016582510 scopus 로고
    • Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood
    • Horwitz D, Starr JL, Mako ME, Blackard WG, Rubenstein AH: Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55:1278-1283, 1975
    • (1975) J Clin Invest , vol.55 , pp. 1278-1283
    • Horwitz, D.1    Starr, J.L.2    Mako, M.E.3    Blackard, W.G.4    Rubenstein, A.H.5
  • 4
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
    • Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D: Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 30:698-702, 1987
    • (1987) Diabetologia , vol.30 , pp. 698-702
    • Ward, W.K.1    LaCava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte, D.6
  • 5
    • 0023759449 scopus 로고
    • Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y: Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 31:355-360, 1988
    • (1988) Diabetologia , vol.31 , pp. 355-360
    • Yoshioka, N.1    Kuzuya, T.2    Matsuda, A.3    Taniguchi, M.4    Iwamoto, Y.5
  • 6
    • 0025989824 scopus 로고
    • Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance
    • Shiraishi I, Iwamoto Y, Kuzuya T, Matsuda A, Kumakura S: Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance. Diabetologia 34:737-741, 1991
    • (1991) Diabetologia , vol.34 , pp. 737-741
    • Shiraishi, I.1    Iwamoto, Y.2    Kuzuya, T.3    Matsuda, A.4    Kumakura, S.5
  • 7
    • 0015416775 scopus 로고
    • Direct measurement of plasma proinsulin in normal and diabetic subjects
    • Duckworth WC, Kitabchi AE, Heinemann M: Direct measurement of plasma proinsulin in normal and diabetic subjects. Am J Med 53:418-427, 1972
    • (1972) Am J Med , vol.53 , pp. 418-427
    • Duckworth, W.C.1    Kitabchi, A.E.2    Heinemann, M.3
  • 8
    • 0016209121 scopus 로고
    • Circulating proinsulin-like component in man: Increased proportion in hypoinsulinaemic states
    • Gorden P, Hendricks CM, Roth J: Circulating proinsulin-like component in man: increased proportion in hypoinsulinaemic states. Diabetologia 10:469-474, 1974
    • (1974) Diabetologia , vol.10 , pp. 469-474
    • Gorden, P.1    Hendricks, C.M.2    Roth, J.3
  • 12
    • 0027251602 scopus 로고
    • Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose intolerance
    • Davies MJ, Rayman G, Gray IP, Day JL, Hales CN: Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose intolerance. Diabet Med 10:313-320, 1993
    • (1993) Diabet Med , vol.10 , pp. 313-320
    • Davies, M.J.1    Rayman, G.2    Gray, I.P.3    Day, J.L.4    Hales, C.N.5
  • 14
    • 85036493279 scopus 로고
    • Recently released β-cell granule constituents as an indicator of proinsulin processing in NIDDM
    • Kahn SE, Halban PA: Recently released β-cell granule constituents as an indicator of proinsulin processing in NIDDM (Abstract). Diabetologia 38 (Suppl. 1):A114, 1995
    • (1995) Diabetologia , vol.38 , Issue.1 SUPPL.
    • Kahn, S.E.1    Halban, P.A.2
  • 15
    • 0027386638 scopus 로고
    • Normal proinsulin responses to glucose in mild type II subjects with subnormal insulin response
    • Levy JC, Clark PM, Hales CN, Turner RC: Normal proinsulin responses to glucose in mild type II subjects with subnormal insulin response. Diabetes 42:162-169, 1993
    • (1993) Diabetes , vol.42 , pp. 162-169
    • Levy, J.C.1    Clark, P.M.2    Hales, C.N.3    Turner, R.C.4
  • 16
    • 0017761172 scopus 로고
    • Circulating proinsulin in patients with maturity onset diabetes
    • Mako ME, Starr JI, Rubenstein AH: Circulating proinsulin in patients with maturity onset diabetes. Am J Med 63:865-869, 1977
    • (1977) Am J Med , vol.63 , pp. 865-869
    • Mako, M.E.1    Starr, J.I.2    Rubenstein, A.H.3
  • 19
    • 0024271685 scopus 로고
    • Reduction of glycemic potentiation: Sensitive indicator of β-cell loss in partially pancreatectomized dogs
    • Ward WK, Wallum BJ, Beard JC, Taborsky GJ, Porte D: Reduction of glycemic potentiation: sensitive indicator of β-cell loss in partially pancreatectomized dogs. Diabetes 37:723-729, 1988
    • (1988) Diabetes , vol.37 , pp. 723-729
    • Ward, W.K.1    Wallum, B.J.2    Beard, J.C.3    Taborsky, G.J.4    Porte, D.5
  • 20
    • 0024463227 scopus 로고
    • Hyperproinsulinemia and amyloid in NIDDM: Clues to etiology of islet β-cell dysfunction?
    • Porte D, Kahn SE: Hyperproinsulinemia and amyloid in NIDDM: clues to etiology of islet β-cell dysfunction? Diabetes 38:1333-1336, 1989
    • (1989) Diabetes , vol.38 , pp. 1333-1336
    • Porte, D.1    Kahn, S.E.2
  • 22
    • 0027217510 scopus 로고
    • Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans
    • Kahn SE, Horber FF, Prigeon RL, Haymond MW, Porte D: Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans. Diabetes 42:1082-1085, 1993
    • (1993) Diabetes , vol.42 , pp. 1082-1085
    • Kahn, S.E.1    Horber, F.F.2    Prigeon, R.L.3    Haymond, M.W.4    Porte, D.5
  • 23
    • 0023932360 scopus 로고
    • Increased proinsulin levels as an early indicator of β-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients
    • Heaton DA, Millward BA, Gray IP, Tun Y, Hales CN, Pyke DA, Leslie RDG: Increased proinsulin levels as an early indicator of β-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia 31:182-184, 1988
    • (1988) Diabetologia , vol.31 , pp. 182-184
    • Heaton, D.A.1    Millward, B.A.2    Gray, I.P.3    Tun, Y.4    Hales, C.N.5    Pyke, D.A.6    Leslie, R.D.G.7
  • 24
    • 0024435846 scopus 로고
    • Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
    • Hartling SG, Lindgren F, Dahlqvist G, Persson B, Binder C: Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 38:1271-1274, 1989
    • (1989) Diabetes , vol.38 , pp. 1271-1274
    • Hartling, S.G.1    Lindgren, F.2    Dahlqvist, G.3    Persson, B.4    Binder, C.5
  • 25
    • 0026585133 scopus 로고
    • Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients
    • Spinas GA, Snorgaard O, Hartling SG, Oberholzer M, Berger W: Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients. Diabetes Care 15:632-637, 1992
    • (1992) Diabetes Care , vol.15 , pp. 632-637
    • Spinas, G.A.1    Snorgaard, O.2    Hartling, S.G.3    Oberholzer, M.4    Berger, W.5
  • 26
    • 0020603334 scopus 로고
    • Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year
    • U.K. Prospective Study of Therapies of Maturity-Onset Diabetes: Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year. Diabetologia 24:404-411, 1983
    • (1983) Diabetologia , vol.24 , pp. 404-411
  • 27
    • 0024496341 scopus 로고
    • Unbiased and flexible iterative computer program to achieve glucose clamping
    • Matthews DR, Hosker JP: Unbiased and flexible iterative computer program to achieve glucose clamping. Diabetes Care 12:156-159, 1989
    • (1989) Diabetes Care , vol.12 , pp. 156-159
    • Matthews, D.R.1    Hosker, J.P.2
  • 28
    • 0028364363 scopus 로고
    • Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects
    • U.K. Prospective Diabetes Study (UKPDS) XI: Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects. Diabet Med 11:534-544, 1994
    • (1994) Diabet Med , vol.11 , pp. 534-544
  • 30
    • 0027436630 scopus 로고
    • Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies
    • Kjems LL, Roder ME, Dinesen B, Hartling SG, Jorgensen PN, Binder C: Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies. Clin Chem 39:2146-2150, 1993
    • (1993) Clin Chem , vol.39 , pp. 2146-2150
    • Kjems, L.L.1    Roder, M.E.2    Dinesen, B.3    Hartling, S.G.4    Jorgensen, P.N.5    Binder, C.6
  • 31
    • 0028314832 scopus 로고
    • Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus
    • Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP: Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus. Diabet Med 11:293-298, 1994
    • (1994) Diabet Med , vol.11 , pp. 293-298
    • Davies, M.J.1    Metcalfe, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 32
    • 0029834356 scopus 로고    scopus 로고
    • Effect of sulfonylurea withdrawal on proinsulin levels, B cell function, and glucose disposal in subjects with non-insulin-dependent diabetes mellitus
    • Prigeon RL, Jacobson RK, Porte D, Kahn SE: Effect of sulfonylurea withdrawal on proinsulin levels, B cell function, and glucose disposal in subjects with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81:3295-3298, 1996
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3295-3298
    • Prigeon, R.L.1    Jacobson, R.K.2    Porte, D.3    Kahn, S.E.4
  • 33
    • 3943110287 scopus 로고
    • Sulphonylurea therapy stimulates basal and post glucose load levels of proinsulin
    • Mohammed-Ali V, Panahloo A, Denver E, Andres C, Yudkin JS: Sulphonylurea therapy stimulates basal and post glucose load levels of proinsulin (Abstract). Diabetologia 38 (Suppl. 1):A115, 1995
    • (1995) Diabetologia , vol.38 , Issue.1 SUPPL.
    • Mohammed-Ali, V.1    Panahloo, A.2    Denver, E.3    Andres, C.4    Yudkin, J.S.5
  • 34
    • 0003348482 scopus 로고
    • C-peptide and proinsulin
    • Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, Eds. Chichester, Wiley
    • Madsbad S, Hartling SG, Faber OK: C-peptide and proinsulin. In International Textbook of Diabetes Mellitus. Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, Eds. Chichester, Wiley, 1992, p. 303-332
    • (1992) International Textbook of Diabetes Mellitus , pp. 303-332
    • Madsbad, S.1    Hartling, S.G.2    Faber, O.K.3
  • 36
    • 0028339912 scopus 로고
    • Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM
    • Polonsky KS, Gumbiner B, Ostrega D, Griver K, Tager H, Henry RR: Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes 43:871-877, 1994
    • (1994) Diabetes , vol.43 , pp. 871-877
    • Polonsky, K.S.1    Gumbiner, B.2    Ostrega, D.3    Griver, K.4    Tager, H.5    Henry, R.R.6
  • 37
    • 0024493106 scopus 로고
    • Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM
    • Yoshioka N, Kuzuya T, Matsuda A, Iwamoto Y: Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM. Diabetes 38:262-266, 1989
    • (1989) Diabetes , vol.38 , pp. 262-266
    • Yoshioka, N.1    Kuzuya, T.2    Matsuda, A.3    Iwamoto, Y.4
  • 38
    • 0028137716 scopus 로고
    • Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus
    • Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP: Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus. Diabet Med 11:71-78, 1994
    • (1994) Diabet Med , vol.11 , pp. 71-78
    • Davies, M.J.1    Metcalfe, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 39
    • 0028230040 scopus 로고
    • What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism
    • Rhodes CJ, Alarcon C: What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes 43:511-517, 1994
    • (1994) Diabetes , vol.43 , pp. 511-517
    • Rhodes, C.J.1    Alarcon, C.2
  • 41
    • 0029050206 scopus 로고
    • Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects
    • Mykkanen L, Haffner SM, Kuusisto J, Pyorala K, Hales CN, Laakso M: Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. Diabetologia 38:1176-1182, 1995
    • (1995) Diabetologia , vol.38 , pp. 1176-1182
    • Mykkanen, L.1    Haffner, S.M.2    Kuusisto, J.3    Pyorala, K.4    Hales, C.N.5    Laakso, M.6
  • 42
    • 0030045866 scopus 로고    scopus 로고
    • Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: The Hoorn Study
    • Nijpels G, Popp-Snijders C, Kostense PJ, Bouter LM, Heine RJ: Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia 39:113-118, 1996
    • (1996) Diabetologia , vol.39 , pp. 113-118
    • Nijpels, G.1    Popp-Snijders, C.2    Kostense, P.J.3    Bouter, L.M.4    Heine, R.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.