Tissue specific transcriptional activity of a pancreatic islet cell-specific enhancer sequence/Pax6-binding site determined in normal adult tissues in vivo using transgenic mice

Molecular Endocrinology

Volumn 13, Issue 5, 1999, Pages 718-728

  Beimesche, Stephan ^a   Neubauer, Andrea ^a   Herzig, Stephan ^a   Grzeskowiak, Rafal ^a   Diedrich, Thomas ^a   Cierny, Irmgard ^a   Scholz, Doris ^a   Alejel, Tahseen ^a   Knepel, Willhart ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INSULIN; MESSENGER RNA; SOMATOSTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

ADOLESCENT; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL MATURATION; CEREBELLUM; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENHANCER REGION; EYE; GENETIC TRANSCRIPTION; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

EID: 0033305059     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.5.0273     Document Type: Article

References (59)

1. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus
2. Insulinpromoter-factor 1 is required for pancreas development in mice
3. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
4. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
5. Pax genes and their roles in cell differentiation and development
6. Pax-6 in development and evolution
7. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas
8. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
9. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
10. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
11. Expression of Stf-1, a putative insulin gene transcription factor, in b-cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
12. IPF1, a homeodomain-containing transactivator of the insulin gene
13. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
14. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
15. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
16. Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines
17. Modulation of glucose-induced insulin secretion from a rat clonal β-cell line
18. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons
19. The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes
20. Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES)
21. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
22. Genetic analysis reveals that Pax6 is required for normal transcription of pancreatic hormone genes and islet development
23. A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins
24. An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer
25. Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor
26. Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation
27. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells
28. + T helper 2 (Th2) cells but not in Th1 cells
29. Roles of pax-genes in developing and adult brain as suggested by expression patterns
30. Pax-6, a murine paired box gene, is expressed in the developing CNS
31. Role of Olf-1 and Pax-6 transcription factors in neurodevelopment
32. Pax-QNR/Pax6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells
33. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region
34. Pax proteins and eye development
35. Antibodies against Pax6 immunostain amacrine and ganglion cells and neuronal progenitors, but not rod precursors, in the normal and regenerating retina of the goldfish
36. Pax6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects
37. Pax6: More than meets the eye
38. Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic α cells
39. Region- and age-specific differences in proglucagon gene expression in the central nervous system of wild-type and glucagonsimian virus-40 T-antigen transgenic mice
40. Glucagon gene expression in vertebrate brain
41. Distribution of somatostatin mRNA in the rat nervous system as visualized by a novel non-radioactive in situ hybridization histochemistry procedure
42. Somatostatin in the retina
43. Transcriptional regulation of the mouse αA-crystallin gene: Activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site
44. A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord
45. POU domain transcription factor brain 4 confers pancreatic α-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
46. The homeobox-containing engrailed (En-1) product down-regulates the expression of Pax-6 through a DNA binding-independent mechanism
47. Pancreatic beta cells express a diverse set of homeobox genes
48. Dual roles for Pax6: A transcriptional repressor of lens fiber cell-specific β-crystallin genes
49. Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hind-brain neurons of transgenic mice
50. Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: Evidence for a conserved function in photoreceptors
51. Structure and DNA-binding properties of Pax-QNR, a paired box- and homeobox-containing gene
52. Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element
53. 2+-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements
54. Characterization of a novel protein kinase C response element in the glucagon gene
55. Distinct properties of the cAMP-responsive element of the rat insulin I gene
56. Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock
57. Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release