The peptide-based thrombin inhibitor CRC 220 is a new substrate of the basolateral rat liver organic anion-transporting polypeptide

Hepatology

Volumn 24, Issue 2, 1996, Pages 380-384

  Eckhardt, Uta ^a   Horz, Jürgen A ^a   Petzinger, Ernst ^a   Stuber, Werner ^b   Reers, Martin ^b   Dickneite, Gerhard ^b   Daniel, Hannelore ^a   Wagener, Meike ^a   Hagenbuch, Bruno ^c   Stieger, Bruno ^c   Meier, Peter J ^c  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Behringwerke AG   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; ASPARTIC ACID; BROMSULFOPHTHALEIN; CARRIER PROTEIN; CHOLIC ACID; CRC 220; DIPEPTIDE; OLIGOPEPTIDE; PHENYLALANINE; POLYADENYLATED RNA; POLYPEPTIDE; TAUROCHOLIC ACID; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG UPTAKE; LIVER; MALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

EID: 15844387507     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008690408     Document Type: Article

References (26)

1. +-independent bile acid uptake systems in the liver. Cell Physiol Biochem 1994;4: 198-205.
2. Petzinger E. Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport. Rev Physiol Biochem Pharmacol 1994; 123:47-211.
3. Frimmer M, Ziegler K. The transport of bile acids in liver cells. Biochim Biophys Acta 1988;947:75-99.
4. Tiribelli C, Lunazzi GC, Sottocasa GL. Biochemical and molecular aspects of the hepatic uptake of organic anions. Biochim Biophys Acta 1990;1031: 261-275.
5. Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. HEPATOLOGY 1991;14:551-566.
6. +/bile acid cotransport system. Proc Natl Acad Sci U S A 1991;88:10629-10633.
7. Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Expression cloning of a sodium-independent organic anion uptake system of rat liver. Proc Natl Acad Sci U S A 1994;91:133-137.
8. Pond MS, Tozer TN. First pass elimination. Basic concepts and clinical consequences. Clin Pharmacokinet 1984;9:1-25.
9. Meijer DKF, Ziegler K. Mechanisms for the hepatic clearance of oligopeptides and proteins: implications for rate of elimination, bioavailability, and cell-specific drug delivery to the liver. In: Audus KL, Raub TJ, eds. Biological barriers to protein delivery. New York: Plenum, 1993:339-392.
10. Wünsch E. Peptide factors as pharmaceuticals: criteria for application. Biopolymers 1983;22:493-505.
11. Caldwell LJ, Parr A, Beihn RM, Agha BJ, Mlodozeniec AR, Jay M, Digenis GA. Drug distribution and biliary excretion pattern of cyclic somatostatin analogs. Pharmacol Res 1985;2:80-83.
12. Ziegler K, Seeberger A. Hepatocellular uptake of peptides-I; carrier-mediated uptake of hydrophilic linear peptides with renin inhibitory activity into isolated rat liver cells. Biochem Pharmacol 1993;45:909-916.
13. Hilpert K, Ackermann J, Banner DW, Gast A, Gubernator K, Hadvary P, Labler L, et al. Design and synthesis of potent and high selective thrombin inhibitors. J Med Chem 1994;37:3889-3901.
14. Stüber W, Koschinsky R, Kolar C, Reers M, Dickneite G, Hoffmann D, Czech J, et al. Inhibition of thrombin by derivatives of the dipeptide aspartic acid-amidinophenylalanine. In: Hodges RS, Smith JA, eds. Peptides, chemistry, structure and biology, Proc XIII Amer Peptide Symp. Leiden: ESCOM, 1994:643-645.
15. Reers M, Koschinsky R, Dickneite G, Hoffmann D, Czech J, Stüber W. Synthesis and characterisation of novel thrombin inhibitors based on 4-amidinophenylalanine. J Enz Inhib 1995;9:61-72.
16. Walter E, Kissel T, Reers M, Dickneite G, Hoffmann D, Stüber W. Transepithelial transport properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data. Pharm Res 1995;12:360-365.
17. Eckhardt U, Stüber W, Dickneite G, Reers M, Petzinger E. First pass elimination of a peptidomimetic thrombin inhibitor is due to carrier-mediated uptake by the liver. Interaction with bile acid transport system. Biochem Pharmacol 1996;52:in press.
18. Colman A. Translation of eucaryotic messenger RNA in Xenopus laevis oocytes. In: Hames BD, Higgins SJ, eds. Transcription and translation: a practical approach. Oxford: IRL Press, 1986:271-302.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium-thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
20. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. Ed 2. New York: Cold Spring Harbor Laboratory, 1989:726-729.
21. Wallace RA, Jared DW, Dumont JN, Sega MW. Protein incorporation by isolated amphibian oocytes. 3. Optimum incubation conditions. J Exp Zool 1973;184:321-333.
22. Kullak-Ublick G-A, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. HEPATOLOGY 1994;20:411-416.
23. +-coupled high affinity peptide transporter (rhaPT) from rabbit kidney cortex. FASEB J 1995;9:5094A.
24. Fei Y-J, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, et al. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 1994;368:563-566.
25. Kramer W, Gutjahr U, Kowalewski S, Girbig F. Interaction of the orally active dianionic cephalosporin cefixime with the uptake system of oligopeptides and a-amino-β-lactam antibiotics in rabbit small intestine. Biochem Pharmacol 1993;46:542-546.
26. Ganapathy V, Leibach FH. Peptide transport in rabbit kidney: studies with L-carnosine. Biochim Biophys Acta 1982;691:362-366.