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Volumn 4, Issue 1, 1999, Pages 61-65

Tumor suppressor gene p16 (CDKN2A) mutation status and promoter inactivation in head and neck cancer

Author keywords

Head and neck cancer; Methylation; Mutation analysis; p16ISK41

Indexed keywords

DNA; PRIMER DNA;

EID: 0033159463     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm.4.1.61     Document Type: Article
Times cited : (51)

References (32)
  • 1
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Scrrano M, Hannon GJ and Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707, 1993.
    • (1993) Nature , vol.366 , pp. 704-707
    • Scrrano, M.1    Hannon, G.J.2    Beach, D.3
  • 2
    • 0344301900 scopus 로고    scopus 로고
    • Role of the p16 tumor suppressor gene in cancer
    • Liggett WH and Sidransky D: Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 16: 1197-1206, 1998.
    • (1998) J Clin Oncol , vol.16 , pp. 1197-1206
    • Liggett, W.H.1    Sidransky, D.2
  • 4
    • 0029060657 scopus 로고
    • Complex structure and regulation of the PI6 (MTS1) locus
    • Stone S, Jiang P, Dayananth P, el a!: Complex structure and regulation of the PI6 (MTS1) locus. Cancer Res 55: 2988-2994, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2988-2994
    • Stone, S.1    Jiang, P.2    Dayananth, P.3
  • 5
    • 0029119852 scopus 로고
    • Cloning and characterization of murinc p16INK4a and p15INK4b genes
    • Quelle DE, Ashmun RA, Hannon GJ, et al: Cloning and characterization of murinc p16INK4a and p15INK4b genes. Oncogenc 11:635-645, 1995.
    • (1995) Oncogenc , vol.11 , pp. 635-645
    • Quelle, D.E.1    Ashmun, R.A.2    Hannon, G.J.3
  • 6
    • 0031771497 scopus 로고    scopus 로고
    • The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced b/DNA methylation and down-reeulated by wild-type p53
    • Robertson KD and Jones PA: The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced b/DNA methylation and down-reeulated by wild-type p53. Mol Cell Biol 18: 6457-6473, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 6457-6473
    • Robertson, K.D.1    Jones, P.A.2
  • 7
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives C: Signaling to p53: breaking the MDM2-p53 circuit. ' Cell 95: 5-8, 1998.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 8
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang YP, Xiong Y and Yarbrough WG: ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92: 725-734, 1998.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.P.1    Xiong, Y.2    Yarbrough, W.G.3
  • 9
    • 9444255067 scopus 로고    scopus 로고
    • High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma
    • Reed AL, Califano J, Cairns P, et al: High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 56: 3630-3633, 1996.
    • (1996) Cancer Res , vol.56 , pp. 3630-3633
    • Reed, A.L.1    Califano, J.2    Cairns, P.3
  • 10
    • 0030612712 scopus 로고    scopus 로고
    • Frequent inactivation of p16(INK4a) in oral premalignant lesions
    • Papadimitrakopoulou V, Izzo J, Lippman SM, et al: Frequent inactivation of p16(INK4a) in oral premalignant lesions. Oncogene 14: 1799-1803, 1997.
    • (1997) Oncogene , vol.14 , pp. 1799-1803
    • Papadimitrakopoulou, V.1    Izzo, J.2    Lippman, S.M.3
  • 12
    • 0031038935 scopus 로고    scopus 로고
    • Alterations of the p16 gene in head and neck cancer: Frequency and association with P53, PRAD-1 and HPV
    • Olshan AF, Wcisslcr MC, Pei H, et al: Alterations of the p16 gene in head and neck cancer: frequency and association with P53, PRAD-1 and HPV. Oncogene 14: 811-818, 1997.
    • (1997) Oncogene , vol.14 , pp. 811-818
    • Olshan, A.F.1    Wcisslcr, M.C.2    Pei, H.3
  • 13
    • 0030611596 scopus 로고    scopus 로고
    • P16MTSI/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx
    • Jarcs P, Fernandez PL, Nadal A, et al: p16MTSI/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx. Oncogene 15: 1445-1453, 1997.
    • (1997) Oncogene , vol.15 , pp. 1445-1453
    • Jarcs, P.1    Fernandez, P.L.2    Nadal, A.3
  • 14
    • 0029011539 scopus 로고
    • 51 CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTSI in human cancers
    • Merlo A, Herman JG, Mao L, et al: 51 CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTSI in human cancers. Nat Med 1: 686-692, 1995.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3
  • 15
    • 0029067841 scopus 로고
    • Methylation and p16: Suppressing the suppressor
    • Little M and Wainwright B: Methylation and p16: suppressing the suppressor. Nat Med 1: 633-634, 1995.
    • (1995) Nat Med , vol.1 , pp. 633-634
    • Little, M.1    Wainwright, B.2
  • 16
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez Zulucta M, Bender CM, Yang AS, et al: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55: 4531-4535, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gonzalez Zulucta, M.1    Bender, C.M.2    Yang, A.S.3
  • 17
    • 0024799116 scopus 로고
    • Increased detcctability of somatic changes in the DNA from human tumours after probing with 'synthetic' and 'genome-derived' hypervariable multilocus probes
    • Lagoda PJ, Seitz G, Epplen JT and Issinger OG: Increased detcctability of somatic changes in the DNA from human tumours after probing with 'synthetic' and 'genome-derived' hypervariable multilocus probes. Hum Genet 84: 35-40, 1989.
    • (1989) Hum Genet , vol.84 , pp. 35-40
    • Lagoda, P.J.1    Seitz, G.2    Epplen, J.T.3    Issinger, O.G.4
  • 19
    • 0028862489 scopus 로고
    • Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16
    • Wick ST, Dubay MM, Imanil I and Brizuela L: Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16. Oncogene 11: 2013-2019, 1995.
    • (1995) Oncogene , vol.11 , pp. 2013-2019
    • Wick, S.T.1    Dubay, M.M.2    Imanil, I.3    Brizuela, L.4
  • 20
    • 0031985318 scopus 로고    scopus 로고
    • Crystal structure of the CDK4/6 inhibitory protein p18(INK4c) provides insights into ankyrin-like repeat structure/function and tumor-derived p16(INK4) mutations
    • Venkataramani R, Swaminathan K and Marmorstein R: Crystal structure of the CDK4/6 inhibitory protein p18(INK4c) provides insights into ankyrin-like repeat structure/function and tumor-derived p16(INK4) mutations. Nat Struct Biol 5: 74-81, 1998.
    • (1998) Nat Struct Biol , vol.5 , pp. 74-81
    • Venkataramani, R.1    Swaminathan, K.2    Marmorstein, R.3
  • 21
    • 0032541623 scopus 로고    scopus 로고
    • Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16(INK4a)
    • Russo AA, Tong L, Lee JO, Jeffrey PD and Pavletich NP: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16(INK4a). Nature 395:237-243, 1998.
    • (1998) Nature , vol.395 , pp. 237-243
    • Russo, A.A.1    Tong, L.2    Lee, J.O.3    Jeffrey, P.D.4    Pavletich, N.P.5
  • 23
    • 0028971713 scopus 로고
    • Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds
    • Walker GJ, Hussussian CJ, Flores JF, et al: Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds. Hum Mol Genet 4: 1845-1852, 1995.
    • (1995) Hum Mol Genet , vol.4 , pp. 1845-1852
    • Walker, G.J.1    Hussussian, C.J.2    Flores, J.F.3
  • 24
    • 0032467112 scopus 로고    scopus 로고
    • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors
    • Heidenreich A, Gaddipati JP, Moul JW and Srivastava S: Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. J Urol 159: 1725-1730, 1998.
    • (1998) J Urol , vol.159 , pp. 1725-1730
    • Heidenreich, A.1    Gaddipati, J.P.2    Moul, J.W.3    Srivastava, S.4
  • 25
    • 0028998866 scopus 로고
    • Mutations associated with familial melanoma impair p16INK4 function
    • Ranade K, Hussussian CJ, Sikorski RS, et al: Mutations associated with familial melanoma impair p16INK4 function. Nat Genet 10: 114-116, 1995.
    • (1995) Nat Genet , vol.10 , pp. 114-116
    • Ranade, K.1    Hussussian, C.J.2    Sikorski, R.S.3
  • 26
    • 0030294842 scopus 로고    scopus 로고
    • MTS1 gene mutations in archival oral squamous cell carcinomas
    • Dawson CD, Chang KW and Solt DB: MTS1 gene mutations in archival oral squamous cell carcinomas. J Oral Pathol Med 25: 541-546, 1996.
    • (1996) J Oral Pathol Med , vol.25 , pp. 541-546
    • Dawson, C.D.1    Chang, K.W.2    Solt, D.B.3
  • 27
    • 12644251969 scopus 로고    scopus 로고
    • Rare mutations of the growth suppressor genes involved in negative regulation of the cell cycle: P15, p16 and p18 genes in oral squamous cell carcinoma
    • Nakanishi H, Uzawa K, Yokoe H, et al: Rare mutations of the growth suppressor genes involved in negative regulation of the cell cycle: p15, p16 and p18 genes in oral squamous cell carcinoma. Int J Oncol 11: 1129-1133, 1997.
    • (1997) Int J Oncol , vol.11 , pp. 1129-1133
    • Nakanishi, H.1    Uzawa, K.2    Yokoe, H.3
  • 28
    • 0030199087 scopus 로고    scopus 로고
    • Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma
    • Sakata K: Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma. J Oral Pathol Med 25: 302-307, 1996.
    • (1996) J Oral Pathol Med , vol.25 , pp. 302-307
    • Sakata, K.1
  • 29
    • 0030837110 scopus 로고    scopus 로고
    • Deletion and methylation of the tumour suppressor gene pl6/CDKN2 in primary head and neck squamous cell carcinoma
    • Gonzalez MV, Pello MF, Lopez Larrea C, Suarez C, Mcncndez MJ and Goto E: Deletion and methylation of the tumour suppressor gene pl6/CDKN2 in primary head and neck squamous cell carcinoma. J Clin Pathol 50: 509-512, 1997.
    • (1997) J Clin Pathol , vol.50 , pp. 509-512
    • Gonzalez, M.V.1    Pello, M.F.2    Lopez Larrea, C.3    Suarez, C.4    Mcncndez, M.J.5    Goto, E.6
  • 30
    • 0031863635 scopus 로고    scopus 로고
    • Frequent mutation of p16 in squamous cell carcinoma of the head and neck
    • Lang JC, Tobin FJ, Knobloch TJ, et al: Frequent mutation of p16 in squamous cell carcinoma of the head and neck. Laryngoscope 108: 923-928, 1998.
    • (1998) Laryngoscope , vol.108 , pp. 923-928
    • Lang, J.C.1    Tobin, F.J.2    Knobloch, T.J.3
  • 31
    • 0030708545 scopus 로고    scopus 로고
    • Methylation, a major mechanism of p!6/CDKN2 gene inactivation in head and neck squamous carcinoma
    • El-Naggar AK, Lai SL, dayman G, et al: Methylation, a major mechanism of p!6/CDKN2 gene inactivation in head and neck squamous carcinoma. Am J Pathol 151: 1767-1774, 1997.
    • (1997) Am J Pathol , vol.151 , pp. 1767-1774
    • El-Naggar, A.K.1    Lai, S.L.2    Dayman, G.3
  • 32
    • 0029898582 scopus 로고    scopus 로고
    • Field cancerization: Are multiple primary cancers monoclonal or polyclonal?
    • Carey TE: Field cancerization: are multiple primary cancers monoclonal or polyclonal? Ann Med 28: 183-188, 1996.
    • (1996) Ann Med , vol.28 , pp. 183-188
    • Carey, T.E.1


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