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Volumn 151, Issue 6, 1997, Pages 1767-1774

Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CLINICAL ARTICLE; COHORT ANALYSIS; DNA DETERMINATION; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; METHYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030708545     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (124)

References (44)
  • 2
    • 0027769876 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDk4
    • Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDk4. Nature 1993, 366:704-707
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 3
    • 0028931152 scopus 로고
    • Inhibition of ras-induced proliferation and cellular transformation by p16INK4
    • Serrano M, Gomez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D: Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science 1995, 267:249-252
    • (1995) Science , vol.267 , pp. 249-252
    • Serrano, M.1    Gomez-Lahoz, E.2    DePinho, R.A.3    Beach, D.4    Bar-Sagi, D.5
  • 5
    • 9544251503 scopus 로고    scopus 로고
    • p 16 and p 16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro
    • Liggett WH, Sewell DA, Rocco J, Ahrendt SA, Koch W, Sidransky D: p 16 and p 16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res 1996, 56:4119-4123
    • (1996) Cancer Res , vol.56 , pp. 4119-4123
    • Liggett, W.H.1    Sewell, D.A.2    Rocco, J.3    Ahrendt, S.A.4    Koch, W.5    Sidransky, D.6
  • 6
    • 0028829571 scopus 로고
    • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage
    • Nakagawa K, Conrad NK, Williams JP, Johnson BE, Kelley MJ: Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. Oncogene 1995, 11: 1843-1851
    • (1995) Oncogene , vol.11 , pp. 1843-1851
    • Nakagawa, K.1    Conrad, N.K.2    Williams, J.P.3    Johnson, B.E.4    Kelley, M.J.5
  • 7
    • 0029121279 scopus 로고
    • Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia
    • Ohnishi H, Kawamura M, Ida K, Sheng XM, Hanada R, Nobori T, Yamamouri S, Hayashi Y: Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. Blood 1995, 86:1269-1275
    • (1995) Blood , vol.86 , pp. 1269-1275
    • Ohnishi, H.1    Kawamura, M.2    Ida, K.3    Sheng, X.M.4    Hanada, R.5    Nobori, T.6    Yamamouri, S.7    Hayashi, Y.8
  • 9
    • 0028808824 scopus 로고
    • Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines
    • Southgate J, Proffitt J, Roberts P, Smith B, Selby P: Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines. Br J Cancer 1995, 72:1214-1218
    • (1995) Br J Cancer , vol.72 , pp. 1214-1218
    • Southgate, J.1    Proffitt, J.2    Roberts, P.3    Smith, B.4    Selby, P.5
  • 11
    • 0028566272 scopus 로고
    • MTS1/CDk4l is altered in cell lives derived from primary and metastatic oral squamous cell carcinoma
    • Yendall WA, Crawford RY, Ensley J, Robbins KC: MTS1/CDk4l is altered in cell lives derived from primary and metastatic oral squamous cell carcinoma. Carcinogenesis 1994, 15:2683-2686
    • (1994) Carcinogenesis , vol.15 , pp. 2683-2686
    • Yendall, W.A.1    Crawford, R.Y.2    Ensley, J.3    Robbins, K.C.4
  • 13
    • 0029066731 scopus 로고
    • p16 gene alterations in nasopharyngeal carcinoma
    • Lo KW, Huang DP, Lau K-M: p16 gene alterations in nasopharyngeal carcinoma. Cancer Res 1995, 55:2039-2043
    • (1995) Cancer Res , vol.55 , pp. 2039-2043
    • Lo, K.W.1    Huang, D.P.2    Lau, K.-M.3
  • 16
    • 0028906985 scopus 로고
    • No point mutation but decreased expression of the p16/ MTS1 tumor suppressor gene in nasopharyngeal carcinomas
    • Sun Y, Hildesheim A, Lanier AEP, Cao Y, Yao K-T, Raab-Traub N, Yang C-S: No point mutation but decreased expression of the p16/ MTS1 tumor suppressor gene in nasopharyngeal carcinomas. Oncogene 1995, 10:785-788
    • (1995) Oncogene , vol.10 , pp. 785-788
    • Sun, Y.1    Hildesheim, A.2    Lanier, A.E.P.3    Cao, Y.4    Yao, K.-T.5    Raab-Traub, N.6    Yang, C.-S.7
  • 17
    • 0029664483 scopus 로고    scopus 로고
    • p16INK4a; A gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression
    • Larsen G-J: p16INK4a; a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression. Oncogene 1996, 12:2041-2044
    • (1996) Oncogene , vol.12 , pp. 2041-2044
    • Larsen, G.-J.1
  • 18
    • 0029912290 scopus 로고    scopus 로고
    • A novel clonality assay for the mouse: Application to hepatocellular carcinomas induced with diethylnitrosamine
    • Tsunashima K, Endo Y, Asakura H, Kanda H, Nomura K, Kitagawa T, Kominami R: A novel clonality assay for the mouse: application to hepatocellular carcinomas induced with diethylnitrosamine. Mol Carcinogen 1996, 15:33-37
    • (1996) Mol Carcinogen , vol.15 , pp. 33-37
    • Tsunashima, K.1    Endo, Y.2    Asakura, H.3    Kanda, H.4    Nomura, K.5    Kitagawa, T.6    Kominami, R.7
  • 19
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen TD, Beart RW, Van Turnout JM, Jones PA: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995, 55: 4531-4535
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.D.4    Beart, R.W.5    Van Turnout, J.M.6    Jones, P.A.7
  • 20
    • 0001068650 scopus 로고
    • DNA methylation in the 5′ region of the mouse PGK-1 gene and a quantitative PCR assay for methylation
    • Edited by Clawson GA, Willis DB, Weissbach A, Jones PA. New York, Alan R Liss
    • Singer-Sam J, Yang TP, Mori N, Tanguay RL, Le Bon JM, Flores JC, Riggs AD: DNA methylation in the 5′ region of the mouse PGK-1 gene and a quantitative PCR assay for methylation. Nucleic Acid Methylation, vol. 128. Edited by Clawson GA, Willis DB, Weissbach A, Jones PA. New York, Alan R Liss, pp 285-289, 1990
    • (1990) Nucleic Acid Methylation , vol.128 , pp. 285-289
    • Singer-Sam, J.1    Yang, T.P.2    Mori, N.3    Tanguay, R.L.4    Le Bon, J.M.5    Flores, J.C.6    Riggs, A.D.7
  • 21
    • 0028820566 scopus 로고
    • LOH and mutation analysis of CDKN2 in primary human ovarian cancers
    • Campbell IG, Beynon G, Davis M, Englefield P: LOH and mutation analysis of CDKN2 in primary human ovarian cancers, Int J Cancer 1995, 63:222-225
    • (1995) Int J Cancer , vol.63 , pp. 222-225
    • Campbell, I.G.1    Beynon, G.2    Davis, M.3    Englefield, P.4
  • 23
    • 0029121213 scopus 로고
    • Mutational analysis of CDKN2 (CDK4I/MTS1) gene in tissues and cell lines of human prostate cancer
    • Komiya A, Suzuki H, Aida S, Yatani R, Shimazaki J: Mutational analysis of CDKN2 (CDK4I/MTS1) gene in tissues and cell lines of human prostate cancer. Jpn J Cancer Res 1995, 86:622-625
    • (1995) Jpn J Cancer Res , vol.86 , pp. 622-625
    • Komiya, A.1    Suzuki, H.2    Aida, S.3    Yatani, R.4    Shimazaki, J.5
  • 24
    • 0028879664 scopus 로고
    • Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers.
    • Shimizu T, Sekiya T: Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers. Int J Cancer 1995, 63:616-620
    • (1995) Int J Cancer , vol.63 , pp. 616-620
    • Shimizu, T.1    Sekiya, T.2
  • 28
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa J-P J, Davidson NE, Sidransky D, Baylin SB: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995, 55:4525-4530
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.-P.J.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 29
    • 0029156810 scopus 로고
    • Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16(MTS1) genes in gliomas
    • Li Y-J, Hoang H-X, Delattre J-Y, Poisson M, Thomas G, Hamelin R: Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16(MTS1) genes in gliomas. Oncogene 1995, 11:597-600
    • (1995) Oncogene , vol.11 , pp. 597-600
    • Li, Y.-J.1    Hoang, H.-X.2    Delattre, J.-Y.3    Poisson, M.4    Thomas, G.5    Hamelin, R.6
  • 30
    • 0029165749 scopus 로고
    • Mutational state of P16/CDKN2 and VHL genes in squamous cell carcinoma of the oral cavity
    • Uzawa K, Suzuki H, Yokoe H, Tanzawa H, Sato K: Mutational state of P16/CDKN2 and VHL genes in squamous cell carcinoma of the oral cavity. Int J Oncol 1995, 7:895-899
    • (1995) Int J Oncol , vol.7 , pp. 895-899
    • Uzawa, K.1    Suzuki, H.2    Yokoe, H.3    Tanzawa, H.4    Sato, K.5
  • 31
    • 0029851041 scopus 로고    scopus 로고
    • Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betal quid chewers
    • Heinzel PA, Balaram P, Bernard HU: Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betal quid chewers. Int J Cancer 1996, 68:420-423
    • (1996) Int J Cancer , vol.68 , pp. 420-423
    • Heinzel, P.A.1    Balaram, P.2    Bernard, H.U.3
  • 34
    • 0028979432 scopus 로고
    • Mutational effects on the p16INk4a tumor suppressor protein
    • Yang R, Gombart AF, Serrano M, Koeffler HP: Mutational effects on the p16INk4a tumor suppressor protein. Cancer Res 1995, 55:2503-2506
    • (1995) Cancer Res , vol.55 , pp. 2503-2506
    • Yang, R.1    Gombart, A.F.2    Serrano, M.3    Koeffler, H.P.4
  • 35
    • 0029898837 scopus 로고    scopus 로고
    • DNA methylation errors and cancer
    • Jones AP: DNA methylation errors and cancer. Cancer Res 1996, 56:2463-2467
    • (1996) Cancer Res , vol.56 , pp. 2463-2467
    • Jones, A.P.1
  • 36
    • 0028787221 scopus 로고
    • CDKN2 gene silencing in lung by DNA hypermethylation and kinetics of p16INk4 protein induction by 5-aza,2-deoxycytidine
    • Otterson GA, Khleif SA, Chen W, Coxon AB, Kaye FJ: CDKN2 gene silencing in lung by DNA hypermethylation and kinetics of p16INk4 protein induction by 5-aza,2-deoxycytidine. Oncogene 1995, 11: 1211-1216
    • (1995) Oncogene , vol.11 , pp. 1211-1216
    • Otterson, G.A.1    Khleif, S.A.2    Chen, W.3    Coxon, A.B.4    Kaye, F.J.5
  • 39
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancer
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancer. Nature Med 1995, 1:686-692
    • (1995) Nature Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 40
    • 0029963169 scopus 로고    scopus 로고
    • p16 inhibition of transformed and primary squamous epithelial cells
    • Enders GH, Koh J, Missero C, Rustgi AK, Harlow E: p16 inhibition of transformed and primary squamous epithelial cells. Oncogene 1996, 12:1239-1245
    • (1996) Oncogene , vol.12 , pp. 1239-1245
    • Enders, G.H.1    Koh, J.2    Missero, C.3    Rustgi, A.K.4    Harlow, E.5
  • 43
    • 0026653420 scopus 로고
    • The essentials of DNA methylation
    • Bird A: The essentials of DNA methylation. Cell 1992, 70:5-8
    • (1992) Cell , vol.70 , pp. 5-8
    • Bird, A.1
  • 44
    • 0029837009 scopus 로고    scopus 로고
    • Methylated CpG points identified within MAGE-1 promoter are involved in gene expression
    • Serrano A, Garcia A, Abril E, Garrido F, Ruiz-Cabello F: Methylated CpG points identified within MAGE-1 promoter are involved in gene expression. Int J Cancer 1996, 68:464-470
    • (1996) Int J Cancer , vol.68 , pp. 464-470
    • Serrano, A.1    Garcia, A.2    Abril, E.3    Garrido, F.4    Ruiz-Cabello, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.