Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2456-2466

  Schuh, Kai ^a   Kneitz, Burkhard ^a   Heyer, Jörg ^a   Bommhardt, Ursula ^a   Jankevics, Eriks ^b   Berberich Siebelt, Friederike ^a   Pfeffer, Klaus ^c   Müller Hermelink, Hans Konrad ^a   Schimpl, Anneliese ^a   Serfling, Edgar ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF LATVIA   (Latvia)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Germinal center; NF AT; T cell activation; Thymus involution

Indexed keywords

NUCLEAR FACTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENHANCER REGION; GERMINAL CENTER; LYMPH NODE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0031928669     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2456::AID-IMMU2456>3.0.CO;2-9     Document Type: Article

References (41)

1. Rao, A., Luo, C. and Hogan, P. G., Transcription factors of the NFAT family: Regulation and function. Annu. Rev. Immunol. 1997. 15: 707-747.
2. McCaffrey, P. G., Luo, C., Kerppola, T. K., Jain, J., Badalian, T. M., Ho, A. M., Burgeon, E., Lane, W. S., Lambert, J. N., Curran, T., Verdine, G. L., Rao, A. and Hogan, P. G., Isolation of the cyclosporin-sensitive transcription factor NFATp. Science 1993. 262: 750-754.
3. Northrop, J. P., Ho, S. N., Chen, L., Thomas, D. J., Timmerman, L. A., Nolan, G. P., Admon, A. and Crabtree, G. R., NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 1994. 369: 497-502.
4. Hoey, T., Sun, Y. L., Williamson, K. and Xu, X., Isolation of two new members of the NFAT gene family and functional characterization of the NFAT proteins. Immunity 1995. 2: 461-472.
5. Masuda, E., Naito, Y., Tokumitsu, H., Campbell, B., Saito, F., Hannum, C., Arai, K. I. and Arai, N., NFATx: a novel member of the NFAT family that is predominantly expressed in the thymus. Mol. Cell. Biol. 1995. 15: 2697-2706.
6. Shaw, J.-P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A. and Crabtree, G. R., Identification of a putative regulator of early T cell activation genes. Science 1988. 241: 202-205.
7. Randak, C., Brabletz, T., Hergenröther, M., Sobotta, I. and Serfling, E., Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer. EMBO J. 1990. 9: 2529-2536.
8. Rooney, J. W., Sun, Y. L., Glimcher, L. H. and Hoey, T., Novel NF-AT sites that mediate activation of the Interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell Biol. 1995. 15: 6299-6310.
9. Duncliffe, K. N., Bert, A. G., Vadas, M. A. and Cockerill, P. N., A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNasel-hypersensitivity site. Immunity 1997. 6: 175-185.
10. Chuvpilo, S., Schomberg, C., Gerwig, R., Heinfling, A., Reeves, R., Grummt, F. and Serfling, E., Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 1993. 21: 5694-5705.
11. Szabo, S. J., Gold, J. S., Murphy, T. L. and Murphy, K. M., Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: role for NF-Y and NF-ATc. Mol. Cell. Biol. 1993. 13: 4793-4805.
12. Tsitsikov, E. N., Ramesh, N. and Gehe, R. S., Structure of the murine CD40 ligand gene. Mol. Immunol. 1994. 31: 895-900.
13. Brunner, T., Yoo, N. J., LaFace, D., Ware, C. F. and Green, D. R., Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. Int. Immunol. 1996. 8: 1017-1026.
14. Wolfe, S. A., Zhou, P., Dotsch, V., Chen, L., You, A., Ho, S. A., Crabtree, G. R., Wagner, G. and Verdine, G. L., Unusual Rel-like architecture in the DNA binding domain of the transcription factor NF-ATc. Nature 1997. 385: 172-176.
15. Luo, C., Burgeon, E. and Rao, A., Mechanisms of transactivation by nuclear factor of activated T cells-1. J. Exp. Med. 1996. 184: 141-147.
16. de la Pompa, J. L., Timmerman, L. A., Takimoto, H., Yoshida, H., Elia, A. J., Samper, E., Potter, J., Wakeham, A., Marengere, L., Langille, B. L., Crabtree, G. R. and Mak, T. W., Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 1998. 392: 182-186.
17. Ranger, A. M., Grusby, M. J., Hodge, M. R., Gravallese, E. M., de la Brousse, F. C., Hoey, T., Mickanin, C., Baldwin, H. S. and Glimcher, L. H., The transcription factor NF-ATc is essential for cardiac valve formation. Nature 1998. 392: 186-190.
18. Hodge, M. R., Ranger, A. M., de la Brousse, F. C., Hoey, T., Grusby, M. J. and Glimcher, L. H., Hyperproliferation and dysregulation of IL-4 expression in NF-ATp deficient mice. Immunity 1996. 4: 397-405.
19. Xanthoudakis, S., Viola, J. P. B., Shaw, K. T. Y., Luo, C., Wallace, J. D., Bozza, P. T., Curran, T. and Rao, A., An enhanced immune response in mice lacking the transcription factor NFAT1. Science 1996. 272: 892-895.
20. Schuh, K., Kneitz, B., Heyer, J., Siebelt, F., Fischer, C., Jankevics, E., Rüde, E., Schmitt, E., Schimpl, A. and Serfling, E., NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokine genes. Immunol. Lett. 1997. 57: 171-175.
21. Ranger, A. M., Hodge, M. R., Gravallese, E. M., Oukka, M., Davidson, L., Alt, F. W., de la Brousse, F. C., Hoey, T., Grusby, M. and Glimcher, L. H., Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 1998. 8: 125-134.
22. Yoshida, H., Nishina, H., Takimoto, H., Marengere, L. E. M., Wakeham, A. C., Bouchard, D., Kong, Y.-Y., Ohteki, T., Shahinian, A., Bachmann, M., Ohashi, P. S., Penninger, J. M., Crabtree, G. R. and Mak, T. W., The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 1998. 8: 115-124.
23. Molkentin, J. D., Lu, J.-R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R. and Olson, E. N., A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998. 93: 215-228.
24. Alimzhanov, M. B., Kuprash, D. V., Kosco-Vilbois, M. H., Luz, A., Turetskaya, R. L., Tarakovsky, A., Rajewsky, K., Nedospasov, S. A. and Pfeffer, K., Abnormal development of secondary lymphoid tissues in lymphtoxin β-deficient mice. Proc. Natl. Acad. Sci. USA 1997. 94: 9302-9307.
25. Kosco-Vilbois, M. H., Zentgraf, H., Gerdes, J. and Bonnefoy, J. Y., To 'B' or not to 'B' a germinal center? Immunol. Today 1997. 5: 225-230.
26. Kneitz, B., Herrmann, T., Yonehara, S. and Schimpl, A., Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 1995. 25: 2572-2577.
27. Sadlack, B., Kühn, R., Schorle, H., Rajewsky, K., Müller, W. and Horak, I., Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur. J. Immunol. 1994. 24: 281-284.
28. Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. and Alt, F. W., Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995. 3: 521-530.
29. Müller-Hermelink, H. K., Marx, A. and Kirchner, T., Thymus and mediastinum. In Damjanov, I. and Linder, J. (Eds.), Mosby-Year Book. Mosby, St. Louis 1996, pp 1218-1243.
30. Kiani, A., Viola, J. P. B., Lichtman, A. H. and Rao, A., Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 1997. 7: 849-860.
31. Lee, H. J., Masuda, E. S., Arai, N., Arai, K.-I. and Yokota, T., Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. J. Biol. Chem. 1995. 270: 17541-17550.
32. Prieschl, E. E., Pendl, G. G., Harrer, N. E. and Baumruker, T., p21ras linked FCR1 to NF-AT family members in mast cells: the AP3-like factor in this cell type is an NF-AT family member. J. Immunol. 1995. 155: 4963-4970.
33. Dolganov, G., Bort, S., Lovett, M., Burr, J., Schubert, L., Short, D., McGurn, M., Gibson, C. and Lewis, D. B., Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood 1996. 87: 3316-3326.
34. Rincon, M. and Flavell, R., Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells. Mol. Cell. Biol. 1997. 17: 1522-1534.
35. Luo, C., Burgeon, E., Carew, J. A., McCaffrey, P. G., Badalian, T. M., Lane, W. S., Hogan, P. G. and Rao, A., Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol. Cell. Biol. 1996. 16: 3955-3966.
36. Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T. and Mulligan, R. C., Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 1991. 65: 1153-1163.
37. Hooper, M., Hardy, K., Handyside, A., Hunter, S. and Monk, M., HRPT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 1987. 326: 292-295.
38. Neumann, M., Grieshammer, T., Chuvpilo, S., Kneitz, B., Lohoff, M., Schimpl, A., Franza, B. R. and Serfling, E., RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO J. 1995. 14: 1991-2004.
39. Ho, A. M., Jain, J., Rao, A. and Hogan, P. G., Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J. Biol. Chem. 1994. 269: 181-186.
40. Shaw, K. T. Y., Ho, A. M., Raghavan, A., Kim, J., Jain, J., Park, J., Sharma, S., Rao, A. and Hogan, P. G., Immunosuppressive drugs prevent a rapid dephosphorylation of the transcription factor NFAT1 in stimulated immune cells. Proc. Natl. Acad. Sci. USA 1995. 92: 11205-11209.
41. Refaeli, Y., van Parijs, L., London, C. A., Tschopp, J., and Abbas, A. K., Biochemical mechanisms of IL-2 regulated Fas-mediated T cell apoptosis. Immunity 8: 615:623.