Level of α-catenin expression in colorectal cancer correlates with invasiveness, metastatic potential, and survival

Journal of Surgical Oncology

Volumn 68, Issue 2, 1998, Pages 92-99

  Raftopoulos, Ioannis ^a,b   Davaris, Panagiotis ^a   Karatzas, Gabriel ^a   Karayannacos, Panagiotis ^a   Kouraklis, Gregory ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b NONE   (United States)

Author keywords

Colorectal cancer; Differentiation; Liver metastases; Lymph node metastases; Prognosis; catenin

Indexed keywords

ALPHA CATENIN;

ARTICLE; CANCER INVASION; CANCER SURVIVAL; COLON ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECTUM ADENOMA; TUMOR DIFFERENTIATION;

EID: 0031809583     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9098(199806)68:2<92::AID-JSO4>3.0.CO;2-F     Document Type: Article

References (30)

1. Albelda SM: Role of the integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 1993;68: 4-17.
2. Takeichi M: Cadherin cell adhesion receptors as a morphological regulator. Science 1991;262:1451-1455.
3. Shiozaki H, Oka H, Inoue M, et al.: E-Cadherin mediated adhesion system in cancer cells. Cancer Suppl 1996;77:1605-1613.
4. Gagliardi G, Kandemir O, Liu D, et al.: Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Arch 1995;426:149-154.
5. Dorudi S, Sheffield JP, Poulsom R, et al.: E-Cadherin expression in colorectal cancer. Am J Pathol 1993;142:981-986.
6. Dorudi S, Hanby AM, Poulsom R, et al.: Level of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 1995;71:614-616.
7. Ozawa M, Baribault H, Kemler R: The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 1989;8:1711-1717.
8. Hoschuetzky H, Aberle H, Kemler R: β-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 1994;127:1375-1380.
9. Rubinfeld B, Souza B, Albert I, et al.: Association of the APC gene product with β-catenin. Science 1993;262:1731-1734.
10. Kadowaki T, Shiozaki H, Inoue M, et al.: E-Cadherin and α-catenin expression in human esophageal cancer. Cancer Res 1994; 54:291-296.
11. Matsui S, Shiozaki H, Inoue M, et al.: Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Arch 1994;424:375-381.
12. Rimm DL, Sinard JH, Morrow JS: Reduced α-catenin and E-cadherin expression in breast cancer. Lab Invest 1995;72:506-512.
13. Andrews NA, Jones AS, Helliwell TR, Kinsella AR: Expression of E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Br J Cancer 1997;75:1474-1480.
14. Shiozaki H, Gofuku J, Inoue M, Tamura S: Correlation between the intercellular adhesion molecule E-cadherin and its associated protein alpha-catenin expression and metastasis in human digestive cancers. Nippon Rinsho 1995;53:1602-1606 [English abst].
15. Skoudy A, Gomez S, Fabre M, Garcia de Herreros A: Alterations in p120-catenin levels are a common event in colon cancer and suggest that the distribution of this protein and E-cadherin is coordinately regulated. Int J Cancer 1996:68:14-20.
16. Shiozaki H, Iihara K, Oka H, et al.: Immunohistochemical detection of α-catenin expression in human cancers. Am J Pathol 1994; 144:667-674.
17. Hugh TJ, Poston GJ, Kinsella AR: Expression of the cytoplasmic proteins α-catenin and β-catenin in primary and metastatic colorectal cancer: Evidence of altered cellular adhesion. Br J Cancer 1997;75:1242 (abst).
18. Van der Wurff AAM, Vermeulen SJT, Van der Linden EPM, et al.: Patterns of α-and β-catenin and E-cadherin expression in colorectal adenomas and carcinomas. J Pathol 1997;182:325-330.
19. Cuevas EC, Bateman AC, Wilkins BS, et al.: Microwave antigen retrieval in immunohistochemistry: A study of 80 antibodies. J Clin Pathol 1994;47:448-452.
20. Valizadeh A, Karayiannakis AJ, El-Hariry I, et al.: Expression of E-cadherin-associated molecules (α-, β-, and γ-catenins and p120) in colorectal polyps. Am J Pathol 1997;150:1977-1984).
21. Van Der Wurff AAM, Kate JT, Van Der Linden EPM, et al.: L-CAM expression in normal, premalignant and malignant colon mucosa. J Pathol 1992;168:287-291.
22. Ochiai A, Akimoto S, Shimoyama Y, et al.: Frequent loss of α-catenin expression in schirrhous carcinomas with scattered cell growth. Jpn J Cancer Res 1994;85:266-273.
23. Shimoyama Y, Hirohashi S: Expression of E-and P-cadherin in gastric carcinomas. Cancer Res 1991;51:2185-2192.
24. Wagner HE, Steele GD Jr, Thomas P: Experimental liver metastases of human colonic cancer: Correlation with degree of differentiation and CEA production. Helv Chir Acta 1992;58:759-761.
25. Breen E, Clarke A, Steele G Jr, Mercurio AM: Poorly differentiated colon carcinoma cell lines deficient in alpha-catenin expression express high levels of surface E-cadherin but lack Ca(2+)-dependent cell-cell adhesion. Cell Adhes Commun 1993;1:239-250.
26. Vermeulen SJ, Bruyneel EA, Bracke ME, et al.: Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells. Cancer Res 1995;55:4722-4728.
27. Breen E, Steele G Jr, Mercurio AM: Role of the E-cadherin/α-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells. Ann Surg Oncol 1995;2:378-385.
28. Van Der Wurff AAM, Arenas JW, Van Der Linden EPM, et al.: L-CAM expression in lymph node and liver metastases of colorectal carcinomas. J Pathol 1994;172:177-182.
29. Oka H, Shiozaki H, Kobayashi K, et al.: Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer. Virchows Arch [A] 1992;421:149-156.
30. Schipper JH, Frixen UH, Behrens J, et al.: E-Cadherin expression in squamous cell carcinomas of head and neck: Inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 1991;51:6328-6337.