The pathogenetic role of HLA-B27 in chronic arthritis

Current Opinion in Immunology

Volumn 10, Issue 1, 1998, Pages 59-66

  López De Castro, Joséa ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HLA B27 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE ANTIGEN;

ANTIGEN PRESENTATION; BACTERIAL INFECTION; BACTERIUM ADHERENCE; CHRONIC ARTHRITIS; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; NONHUMAN; PATHOGENESIS; REVIEW; SPONDYLOARTHROPATHY; TRANSGENE;

EID: 0032006144     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80033-2     Document Type: Article

References (74)

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2. *2703 to AS in this population does not imply a differential pathogenetic role of this subtype.
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49. 2m alone. Nitric oxide production was impaired in the HLA-B27 transfectant cells, relative to the other transfectants, which correlated with longer survival of Salmonella. The differences among transfectants in the survival of intracellular bacteria were abolished with an inhibitor of nitric oxide production. Because multiple HLA-B27 transfectant lines were not tested, the direct involvement of HLA-B27 in impairing nitric oxide production was not formally established.
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52. Khare SD, Luthra HS, David CS. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking β2-microglobulin: a model of human spondyloarthropathies. J Exp Med. 182:1995;1153-1158.
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59. b backgrounds. Differences in H-Y antigen presentation and in the repertoire of B27-bound peptides were found, but disease susceptibility was the same in both backgrounds. Since both allelic transporters allow for many peptides to be transported equally, this study does not provide evidence against peptide involvement in B27-associated disease in the rat.
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63. 2m is required. The results suggest a role of altered antigenic or peptide-presenting properties of HLA-B27 in the pathogenesis of this murine disease.
64. 2m. This correlated with cell-surface expression of free B27 heavy chains in peripheral blood and in the thymus. In vivo treatment with an antibody specific for HLA class I heavy chains decreased disease incidence, although the statistical significance of this effect was not analysed. A direct role of HLA-B27 heavy chains in disease was proposed.
65. Brown M, Wordsworth P. Predisposing factors to spondyloarthropathies. of special interest Curr Opin Rheumatol. 9:1997;308-314 An excellent review on the role of genes other than HLA-B27 in susceptibility to ankalosing spondylitis.
66. Awada H, Baddoura R, Naman R, Klayme S, Mansour I, Tamouza R, Marzais F, Raffoux C, Toubert A, Charron D. Weak association between HLA-B27 and the spondyloarthropathies in Lebanon. of special interest Arthritis Rheum. 40:1997;388-390 A population study in Lebanon showed much weaker association of HLA-B27 with spondyloarthropathies than in Caucasian populations. This suggests that non-B27 factors are particularly important in predisposing to spondyloarthopathy in the population analysed.
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68. Kuipers JG, Raybourne RB, Williams KM, Zeidler H, Yu DT. Specificities of human TAP alleles for HLA-B27 binding peptides. of special interest Arthritis Rheum. 39:1996;1892-1895 The translocation of a panel of B27-binding nonamers by different human transporter associated with antigen processing (TAP) allelic products failed to reveal differences in peptide specificity.
69. Soizic D, Caillat-Zucman S, Hammer J, Bach JF, Van Endert PM. Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection. of special interest J Immunol. 159:1997;2350-2357 The peptide selectivity and transport efficiency of the most common transporter associated with antigen processing (TAP) allelic products were analysed with microsomes of the Sf9 insect cells containing TAP1/2 combinations, peptide libraries and polyalanine peptides with substitutions of multiple positions. The results failed to reveal any differences in peptide specificity, or in the efficiency and kinetics of peptide translocation, suggesting that TAP polymorphism does not influence HLA-associated diseases.
70. *2704 alleles were in strong linkage disequilibrium each with a different MICA allele (MICA007 and MICA010, respectively) in the Japanese population, indicating that each B27 subtype takes part in a different haplotype.
71. Goto K, Ota M, Ohno S, Mizuki N, Ando H, Katsuyama Y, Maksymowych WP, Kimura M, Bahram S, Inoko H. MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism. of special interest Tissue Antigens. 49:1997;503-507 Microsatellite allelic polymorphism in the transmembrane coding region of the MHC class I chain-related A locus (MICA) gene was described. One of the alleles was in strong linkage disequilibrium with HLA-B27, but was significantly more frequent among B27-positive-patients than in controls. This suggested that additional closely linked genetic factors, but not the MICA gene itself, might influence disease susceptibility in B27 individuals. HLA-B27 subtype distribution in the control and patients groups, which could influence phenotypic frequencies of MICA alleles in linkage disequilibrium with subtypes, was not analysed.
72. *2706. Immunogenetics. 43:1996;160-162.
73. Fernandez-Viña MA, Lazaro AM, Nulf CJ, Stastny P. Nucleotide sequence of novel subtypes of HLA-B27, B55, and B57 [abstract]. Hum Immunol. 49:1996;43.
74. *2711) endocing an antigen reacting with both B27- and B40-specific antisera. Tissue Antigens. 49:1997;649-652.