T Cell Clonality in Synovial Fluid of a Patient with Rheumatoid Arthritis: Persistent but Fluctuant Oligoclonal T Cell Expansions

Journal of Immunology

Volumn 159, Issue 10, 1997, Pages 5143-5149

  Kato, Tomohiro ^a   Kurokawa, Manae ^a   Masuko Hongo, Kayo ^a   Sasakawa, Hiroko ^a,b   Sekine, Taichi ^a,b   Ueda, Shinichiro ^a   Yamamoto, Kazuhiko ^c   Nishioka, Kusuki ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b LSI MEDIENCE CORPORATION   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CELL CLONE; DNA SEQUENCE; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MULTIGENE FAMILY; PATHOLOGY; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE SUBPOPULATION; TIME;

AMINO ACID SEQUENCE; ARTHRITIS, RHEUMATOID; CLONE CELLS; FEMALE; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE ANALYSIS, DNA; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

EID: 0031573213     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Nepom, G. T., P. Byers, C. Seyfies, L. A. Healey, K. R. Wilske, D. Stage, and B. S. Nepom. 1989. HLA genes associated with rheumatoid arthritis. Arthritis Rheum. 32:15.
2. Todd, J. A., H. Acha-Orbea, J. I. Bell, N. Chao, Z. Fronek, C. O. Jacob, M. McDermott, A. A. Sinha, L. Timmerman, L. Steinman, and H. O. McDevutt. 1988. A molecular basis for MHC class II-associated autoimmunity. Science 240:1003.
3. Hammer, J., F. Gallazzi, E. Bono, R. W. Karr, J. Guenot, P. Valsasnini, Z. A. Nagy, and F. Sinigaglia. 1995. Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J. Exp. Med. 181: 1847.
4. + T cells in rheumatoid arthritis. J. Clin. Invest. 94:2068.
5. Walser-Kuntz, D. R., C. M. Weyand, A. J. Weaver, W. M. O'Fallon, and J. J. Goronzy. 1995. Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis. Immunity 2:597.
6. Panayi, G. S., J. S. Lanchbury, and G. H. Kingsley. 1992. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 35:729.
7. Struyk, L., G. E. Hawes, M. K. Chatila, F. C. Breedveld, J. T. Kurnick, and P. J. van den Elsen. 1995. T cell receptors in rheumatoid arthritis. Arthritis Rheum. 38:577.
8. Engle, I., and S. M. Hedric. 1992. Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition. Cell 54:473.
9. Jorgensen, J., U. Esser, F. de St. Groth, P. Reay, and M. M. Davis. 1992. Mapping T cell receptor-peptide contacts by variant peptide immunization of single-chain transgenic. Nature 355:224.
10. Yamamoto, K., H. Sakoda, T. Nakajima, T. Kato, M. Okubo, M. Dohi, Y. Mizushima, K. Ito, and K. Nishioka. 1992. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int. Immunol. 4:1219.
11. Ikeda, Y., K. Masuko, Y. Nakai, T. Kato, T. Hasunuma, S. Yoshino, Y. Mizushima, K. Nishioka, and K. Yamamoto. 1996. High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses. Arthritis Rheum. 39:446.
12. Alam, A., N. Lambert, J. Lule, H. Coppin, B. Mazieres, C. de Preval, A. Cantagrel. 1996. Persistence of dominant T cell clones in synovial tissues during rheumatoid arthritis. J. Immunol. 156:3480.
13. Gonzales-Quintial, R., R. Baccala, R. M. Pope, and A. N. Theofilopoulos. 1996. Identification of clonally expanded T cells in rheumatoid arthritis using sequence enrichment nuclease assay. J. Clin. Invest. 97:1335.
14. Khazaei, H. A., C. Lunardi, and A. K. So. 1995. CD4 T cells in the rheumatoid joints are oligoclonally activated and change during the course of disease. Ann. Rheum. Dis. 54:314.
15. Modlin, R. L., J. Melancon-Kaplan, S. M. M. Young, C. Pirmez, H. King, J. Convit, T. H. Rea, and B. R. Bloom. 1988. Learning from lesions: patterns of tissue inflammation in leprosy. Proc. Natl. Acad. Sci. USA 1213:1217.
16. Conceica-Silva, F., A. O. Schubach, R. S. Nogueria, and S. G. Coutinho. 1978. Quantitation of T cells which recognize Leishmania braziliensis braziliersis (Lbb) antigens in lesions and peripheral blood of cutaneous or mucosal leishmaniasis patients by limiting dilution analysis. Mem. Inst. Oswaldo Cruz. 82:118.
17. Sun, J., H. Link, T. Olsson, B. G. Xiao, G. Anderson, H. P. Ekre, C. Linington, and P. Diener. 1991. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 146:1490.
18. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
19. Choi, Y., B. Kotzin, L. Herron, J. Callahan, P. Marrack, and J. Kappler. 1989. Interaction of staphylococcus aureus toxin 'superantigens' with human T cells. Proc. Natl. Acad. Sci. USA 86:8941.
20. Toyonaga, B., Y. Yoshikai, V. Vadasz, B. Chin, and T. Mak. 1985. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor β-chain. Proc. Natl. Acad. Sci. USA 82:8624.
21. Nanki, T., H. Kohsaka, N. Mizushima, W. E. R. Ollier, D. A. Carson, and N. Miyasaka. 1996. Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. J. Clin. Invest. 98:1335.
22. Wood, W. I., J. Gitschier, L. A. Lasky, and R. M. Lawn. 1985. Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc. Natl. Acad. Sci. USA 82:1585.
23. Jacobs, K. A., R. Rudersdorf, S. D. Neill, J. P. Dougherty, E. L. Brown, and E. F. Fritsch. 1988. The thermal stability of oligonucleotide duplexes is sequence independent in tetraalkylammonium salt solutions: application to identifying recombinant DNA clones. Nucleic Acids Res. 16:4637.
24. Paliard, X., S. G. West, J. A. Lafferty, J. R. Clements, J. W. Lappler, P. Marrack, and B. L. Kotzin. 1991. Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325.
25. Raaphorst, F. M., E. L. Kaizel, M. J. D. von Tol, J. M. Vossen, and P. J. van den Elsen. 1993. Non-random employment of Vβ6 and Jβ gene elements and conserved amino acid usage in CDR3 regions of human fetal and adult TCR chain rearrangements. Int. Immunol. 6:1.
26. Robinson, M. A. 1992. Usage of human T-cell receptor Vβ, Jβ, Cβ, and Vα gene segments is not proportional to gene number. Hum. Immunol. 35:60.
27. Pitzalis, C., G. Kingsley, J. S. S. Lanchbury, J. Murphy, and G. S. Panayi. 1987. Expression of HLA-DR, DQ, and DP antigens and interleukin-2 receptor on synovial fluid T lymphocyte subsets in rheumatoid arthritis: evidence for "frustrated activation." J. Rheum. 14:662.
28. Helmer, M. E., D. Glass, J. S. Coblyn, and J. G. Jacobson. 1986. Very late activation antigens on rheumatoid synovial fluid T lymphocytes: association with stages of T cell activation. J. Clin. Invest. 78:696.
29. Firestein, G. S., and N. J. Zvaifler. 1987. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum. 30:684.
30. Firestein, G. S., D. D. Xu, K. Townsend, K. Brodie, J. M. Alvaro-Gracia, A. Glasebrook, and N. J. Zvaifler. 1988. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J. Exp. Med. 168:1573.
31. Miossec, P., M. Naviliat, J. Sany, and J. Banchereau. 1989. Interleukin 4 in rheumatoid synovitis. Arthritis Rheum. 32:S153 (Abstr.).
32. Saxne, T., M. A. Palladino, Jr., D. Heinegard, N. Talal, and F. A. Wollheim. 1988. Detection of tumor necrosis factor a but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum. 31:1041.
33. Rocha, B., M. P. Lembezat, A. Freitas, and A. Banderira. 1989. Interleukin 2 receptor expression and interleukin 2 production in exponentially growing T cell: major differences between in vivo and in vitro proliferating T lymphocytes. Eur. J. Immunol. 19:1137.
34. Bon, A. L., B. Lucas, F. Vasseur, C. Penit, and M. Papiernik. 1989. In vivo T cell response to viral superantigen. J. Immunol. 156:4602.
35. Pitzalis, C., G. Kingsley, J. Murphy, and G. S. Panayi. 1987. Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint. Clin. Immunol. Immunopathol. 45:252.
36. Matthews, N., P. Emery, D. Pilling, A. Akbar, and A. Salmon,. 1993. Subpopulation of primed T helper cells in rheumatoid arthritis. Arthritis Rheum. 36:603.