The umbilical cord blood αβ T-cell repertoire: Characteristics of a polyclonal and naive but completely formed repertoire

Blood

Volumn 91, Issue 1, 1998, Pages 340-346

  Garderet, Laurent ^b   Dulphy, Nicolas ^b   Douay, Corinne ^b   Chalumeau, Nathalie ^b   Schaeffer, Véronique ^b   Zilber, Marie Thérèse ^b   Lim, Annick ^b   Even, Jos ^b   Mooney, Nuala ^b   Gelin, Catherine ^b   Gluckman, Eliane ^b   Charron, Dominique ^b   Toubert, Antoine ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; RNA; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS TOXIN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE; HUMAN; HUMAN CELL; NEWBORN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSPLANTATION; UMBILICAL CORD BLOOD;

EID: 0031975093     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.1.340.340_340_346     Document Type: Article

References (44)

1. Wagner JE, Kernan NA, Steinbuch M, Broxmeyer HE, Gluckman E: Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 346:214, 1995
2. Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC, Ciocci G, Carrier C, Stevens CE, Rubinstein P: Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 335:157, 1996
3. Wagner JE, Rosenthal J, Sweetman R, Shu XO, Davies SM, Ramsay NKC, McGlave PB, Sender L, Cairo MS: Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: Analysis of engraftment and acute graft-versus-host disease. Blood 88:795, 1996
4. Gluckman E, Rocha V, Boyer Chammard A, Locatelli F, Arcese W, Souillet G, for Eurocord Transplant Group: Results of cord blood transplants in Europe. Blood 88:485a, 1996 (abstr)
5. Harris DT, Schumacher MJ, Locascio J, Besencon FJ, Olson GB, DeLuca D, Shenker L, Bard J, Boyse EA: Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proc Natl Acad Sci USA 89:10006, 1992
6. Garban F, Ericson M, Roucard C, Rabian-Herzog C, Teisserenc H, Sauvanet E, Charron D, Mooney N: Detection of empty HLA class II molecules on cord blood B cells. Blood 87:3970, 1996
7. Ridson G, Gaddy J, Horie M, Broxmeyer HE: Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells. Proc Natl Acad Sci USA 92:2413, 1995
8. Takahashi N, Imanishi K, Nishida H, Uchiyama T: Evidence for immunologic immaturity of cord blood T cells. Cord blood T cells are susceptible to tolerance induction to in vitro stimulation with a superantigen. J Immunol 155:5213, 1995
9. Harris DT, LoCascio J, Besencon FJ: Analysis of the alloreactive capacity of human umbilical cord blood: Implications for graft-versus-host disease. Bone Marrow Transplant 14:545, 1994
10. Morita CT, Parker CM, Brenner MB, Band H: TCR usage and functional capabilities of human γδ T cells at birth. J Immunol 153:3979, 1994
11. Wei S, Charmley P, Robinson MA, Concannon P: The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40:27, 1994
12. LaRocque R, Robinson MA: Diversity in the human T cell receptor beta chain. Hum Immunol 48:3, 1996
13. Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA: An αβ T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274:209, 1996
14. Panzara MA, Oksenberg JR, Steinman L: The polymerase chain reaction for detection of T cell antigen receptor expression. Curr Opin Immunol 4:205, 1992
15. Genevee C, Farace F, Chung V, Diu A, Raffoux C, Charron D, Hercend T, Triebel F: Influence of Human Leukocyte Antigen genes on TCR V gene segment frequencies. Int Immunol 6:1497, 1994
16. Pannetier C, Cochet M, Darche S, Casrouge A, Zöller M, Kourilsky P: The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segment. Proc Natl Acad Sci USA 90:4319, 1993
17. Even J, Lim A, Puisieux I, Ferradini L, Dietrich PY, Toubert A, Hercend T, Triebel F, Pannetier C, Kourilsky P: T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain size determination: Evidence for oligoclonal expansions in tumours and inflammatory diseases. Res Immunol 146:65, 1995
18. Chomczynski P, Saachi N: Single-step method of RNA isolation by acid guanidium thiocyanater-phenol-chloroform extraction. Anal Biochem 162:156, 1987
19. Puisieux I, Even J, Pannetier C, Jotereau F, Favrot M, Kourilsky P: Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J Immunol 153:2807, 1994
20. Currier JR, Yassai M, Robinson MA, Gorski J: Molecular defects in TCRBV genes preclude thymic selection and limit the expressed TCR repertoire. J Immunol 157:170, 1996
21. Boumsell L: T-cell antigen report, in Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder T, Todd R (eds): Leucocyte Typing V. Proceedings of the Fifth International Workshop, Oxford, Great Britain, Oxford University Press, 1995
22. Cochet M, Pannetier C, Regnault A, Darche S, Leclerc C, Kourilsky P: Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Bur J Immunol 22:2639, 1992
23. Schwab R, Szabo P, Manavalan JS, Weksler ME, Posnett DN, Pannetier C, Kourilsky P, Even J: Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 158:4493, 1997
24. Hingorani R, Choi IH, Akolkar P, Gulwam-Akolkar B, Pergolizzi R, Silver J, Gregersen PK: Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J Immunol 151:5762, 1993
25. Raaphorst FM, Kaijzel EL, van Tol MJD, Vossen JM, van den Elsen PJ: Non-random employment of Vβ6 and Jβ gene elements and conserved amino acid usage profiles in CDR3 regions of human fetal and adult TCR β chain rearrangements. Int Immunol 6:1, 1993
26. Quiros Roldan E, Sottini A, Bettinardi A, Albertini A, Imberti L, Primi D: Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells. Immunogenetics 41:91, 1995
27. Kappler J, Kotzin B, Herron L, Gelfand EW, Bigler RD, Boylston A, Carrel S, Posnett DN, Choi Y, Marrack P: V beta-specific Stimulation of human T cells by staphylococcal toxins. Science 224:811, 1989
28. low T cells in the human cord blood. J Immunol 152:5613, 1994
29. Newton DW, Dohlsten M, Olsson C, Segren S, Lundin KEA, Lando PA, Kalland T, Kotb M: Mutations in the MHC class II binding domains of staphylococcal enterotoxin A differentially affect T cell receptor Vβ specificity. J Immunol 157:3988, 1996
30. Rosenberg WMC, Moss PAH, Bell JI: Variation in human T cell receptor Vβ and Jβ repertoire: Analysis using anchor polymerase chain reaction. Eur J Immunol 22:541, 1992
31. Rieux-Laucat F, LeDeist F, Selz F, Fischer A, de Villartay JP: Normal T cell receptor Vβ usage in a primary immunodeficiency associated with HLA class II deficiency. Eur J Immunol 23:928, 1993
32. Robinson MA: Usage of human T cell receptor Vβ, Jβ, Cβ, and Vα gene segments is not proportional to gene number. Hum Immunol 35:60, 1992
33. Donahue JP, Ricalton NS, Behrendt CE, Ritterhaus C, Calaman S, Marrack P, Kappler JW, Kotzin BL: Genetic analysis of lew Vβ3 expression in humans. J Exp Med 179:1701, 1994
34. George JF, Schroeder HW: Developmental regulation of Dβ reading frame and junctional diversity in T cell receptor-β transcripts from human thymus. J Immunol 148:1230, 1992
35. Raaphorst FM, vanBergen J, Langlois van den Bergh R, van der Keur M, de Krijger R, Bruining J, van Tol JD, Vossen JM, van den Elsen P: Usage of TCRAV and TCRBV gene families in human fetal and adult TCR rearrangements, Immunogenetics 39:343, 1994
36. Moss PAH, Bell JI: Sequence analysis of the human αβ T-cell receptor CDR3 region. Immunonogenetics 42:40, 1995
37. Mortari F, Wang JY, Schroeder HW: Human cord blood antibody repertoire. Mixed population of Vh gene segments and CDR3 distribution in the expressed Ca and Cγ repertoires. J Immunol 150:1348, 1993
38. Currier JR, Deulofeut H, Barron KS, Kehn PJ, Robinson MA: Mitogens, superantigens and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity. Hum Immunol 48:39, 1996
39. Hudson KR, Robinson H, Fraser JD: Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor Vβ specificity. J Exp Med 177:175, 1993
40. Dietrich PY, Caignard A, Lim A, Chung V, Pico J, Pannetier C, Kourilsky P, Hercend T, Even J, Triebel F: In vivo T-cell clonal amplification at time of acute graft-versus-host disease. Blood 84:2815, 1994
41. Gaschet J, Lim A, Liem L, Vivien R, Hallet MM, Harousseau JL, Even J, Goulmy E, Bonneville M, Milpied N, Vie H: Acute graft versus host disease due to T lymphocytes recognizing a single HLA-DPB1*0501 mismatch. J Clin Invest 98:100, 1996
42. Roux E, Helg C, Dumont-Girard F, Chapuis B, Jeannet M, Roosnek E: Analysis of T-cell repopulation after allogeneic bone marrow transplantation: Significant differences between recipients of T-cell depleted and unmanipulated grafts. Blood 87:3984, 1996
43. Liu X, Chesnokova V, Forman SJ, Diamond DJ: Molecular analysis of T-cell receptor repertoire in bone marrow transplant recipients: Evidence for oligoclonal T-cell expansion in graft-versus-host disease lesions. Blood 87:3032, 1996
44. Gorski J, Yassai M, Zhu X, Kissella B, Keever C, Flomenberg N: Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. J Immunol 152:5109, 1994