Predisposing factors to spondyloarthropathies

Current Opinion in Rheumatology

Volumn 9, Issue 4, 1997, Pages 308-314

  Brown, Matthew ^a   Wordsworth, Paul ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B60 ANTIGEN; UNCLASSIFIED DRUG;

ANKYLOSING SPONDYLITIS; ANTIGEN PRESENTATION; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; SPONDYLOARTHROPATHY;

EID: 0030861686     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-199707000-00006     Document Type: Review

References (93)

1. Jarvinen P: Occurrence of ankylosing spondylitis in a nationwide series of twins. Arthritis Rheum 1995, 38:381-383.
2. Brown M, Kennedy L, MacGregor A, Darke C, Duncan E, Shatford J, Taylor A, Calin A, Wordsworth B: Genetic susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 1997: in press.
3. Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez SJ, Balish E, Hammer RE: The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994, 180:2359-2364.
4. Risch N: Linkage strategies for genetically complex traits. I: multilocus models [see comments]. Am J Hum Genet 1990, 46:222-228.
5. Lawrence JS: Rheumatism in Populations. London: Heinemann; 1977.
6. Rubin LA, Amos CI, Wade JA, Martin JR, Bale SJ, Little AH, Gladman DD, Bonney GE, Rubenstein JD, Siminovitch KA: Investigating the genetic basis for ankylosing spondylitis: linkage studies with the major histocompatibility complex region. Arthritis Rheum 1994, 37:1212-1220.
7. Brown M, Pile K, Gibson K, Kennedy L, Calin A, Farrall M, Wordsworth B: The HLA component of the genetic contribution to ankylosing spondylitis [abstract]. Br J Rheumatol 1995, 34(suppl 1):72.
8. van der Linden J, Cats A, Keunig J, Van Rood J, Wuisman J: HL-A 27 and ankylosing spondylitis. Ann Rheum Dis 1975, 34:(suppl):53.
9. Deshayes P, Demangeon S, Cavelier B, Le Loet X, Daragon A, Ropartz C: Genetic study of a family of subjects with ankylosing spondylitis [in French]. Rev Rhum Mal Osteoartic 1987, 54:171-174.
10. Woodrow JC: Genetics of the spondarthropathies. Baillieres Clin Rheumatol 1988, 2:603-622.
11. Nahal R, Gautreau C, Amor B, Berthelot J-M, Combes B, Dougados M, Duquesnoy B, Miossec P, Sauraux A, Breban M: Genetic investigation in familial spondyloarthropathy (SpA) with focus on HLA region using transmission desequilibrium test (TDT). Arthritis Rheum 1996, 39:S122. Confirms role of B27 and suggests linkage of DR1-DQ5 independent of B27 in susceptibility to ankylosing spondylitis.
12. Brown MA, Pile KD, Kennedy LG, Calin A, Darke C, Bell J, Wordsworth BP, Cornelis F: HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Ann Rheum Dis 1996, 55:268-270. Case-control study of British ankylosing spondylitis patients and healthy B27-positive bone marrow donors. No difference in B27 subtype distribution was noted. An association with B60 in B27-positive and B27-negative cases was confirmed.
13. Gladman DD, Urowitz MB, Anhorn KA, Chalmers A, Mervart H: Discordance between HLA-B27 and ankylosing spondylitis: a family investigation. J Rheumatol 1986, 13:129-136.
14. Skomsvoll JF, Ostensen M, Romberg O, Anda S: HLA-B27 negative ankylosing spondylitis in a father and a son. Scand J Rheumatol 1995, 24:321-322.
15. Greenberg A: Linkage analysis of "necessary" disease loci versus "susceptibility" loci. Am J Hum Genet 1993, 52:135-143.
16. Benjamin R, Parham P: Guilt by association: HLA-B27 and ankylosing spondylitis [see comments]. Immunol Today 1990, 11:137-142.
17. Archer JR, Whelan MA, Badakere SS, McLean IL, Archer IV, Winrow VR: Effect of a free sulphydryl group on expression of HLA-B27 specificity. Scand J Rheumatol Suppl 1990, 87:44-50.
18. Woodrow JC: Genetic aspects of the spondyloarthropathies. Clin Rheum Dis 1985, 11:1-24.
19. Nickerson CL, Luthra HS, Savarirayan S, David CS: Susceptibility of HLA-B27 transgenic mice to Yersinia enterocolitica infection. Hum Immunol 1990, 28:382-396.
20. Davenport MP: The promiscuous 827 hypothesis [letter]. Lancet 1995, 346:500-501.
21. Damato M, Fiorillo M, Carcassi C, Mathieu A, Zuccarolli A, Bitti P, Tosi R, Sorrentino R: Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis. Eur J Immunol 1995, 25:3199-3201.
22. Lopez-Larrea C, Sujirachato K, Mehra NK, Chiewsilp P, Isarangkura D, Kanga U, Dominguez O, Coto E, Pena M, Setien F, et al.: HLA-B27 subtypes in Asian patients with ankylosing spondylitis: evidence for new associations. Tissue Antigens 1995, 45:169-176.
23. Nasution A, Majuardi A, Kunmartini S, Lardy N, Feltkamp T: HLA-B27 subtypes and their association with ankylosing spondylitis. Melbourne: Proceedings of APLAR Congress of Rheumatology 1996:P43.
24. Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Greenwood BM, McMichael AJ: HLA class I typing by PCR: HLA-B27 and an African B27 subtype [see comments]. Lancet 1991, 337:640-642.
25. Brown M, Jepson A, Young A, Whittle H, Greenwood B, Wordsworth B: Spondyloarthritis in West Africa: evidence for a non-HLA B27 protective effect. Ann Rheum Dis 1997, 56:68-70. Survey of a rural West African population demonstrating an absence of spondyloarthritis in carriers of either B*2703 or B*2705.
26. Reveille J, Fraser P, Taurog J, Pollack M, Ahearn J, Khan M, Appleyard J, Arnett F: HLA-B27 subtypes in African Americans with spondyloarthropathy (SpA). Arthritis Rheum 1996, 39:8204.
27. MacLean L: HLA-B27 subtypes: implications for the spondyloarthropathies. Ann Rheum Dis 1992, 51:929-931.
28. Fiorillo M, Greco G, Sorrentino R: The Asp116-His116 substitution in a novel HLA-B27 subtype influences the acceptance of the peptide C-terminal anchor. Immunogenetics 1995, 41:38-39.
29. Fruci D, Butler RH, Greco G, Rovero P, Pazmany L, Vigneti E, Tosi R, Tanigaki N: Differences in peptide-binding specificity of two ankylosing spondylitis-associated HLA-B27 subtypes. Immunogenetics 1995, 42:123-128.
30. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD: Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 1990, 63:1099112.
31. Chicz RM, Urban RG, Gorga JC, Vignali DA, Lane WS, Strominger JL: Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med 1993, 178:27-47.
32. Scofield RH, Kurien B, Gross T, Warren WL, Harley JB: HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies. Lancet 1995, 345:1542-1544.
33. Breban M, Fernandez-Sueiro J, Richardson J, Hadavand R, Maika S, Hammer R, Taurog J: T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 1996, 156:794-803. Bone marrow transplants in thymic and athymic rats were used to demonstrate that CD4 lymphocytes are required for transfer of disease from B27-transgenic rats to other rat strains.
34. Gaston J, Life P, Granfors K, Merilahti-Palo R, Bailey L, Consalvey S, Toivanen A, Bacon P: Synovial T lymphocyte recognition of organisms that trigger reactive arthritis. Clin Exp Immunol 1989, 76:348-353.
35. Hermann E, Yu DT, Meyer zBK, Fleischer B: HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis [see comments]. Lancet 1993, 342:646-650.
36. Taurog JD, Maika SD, Simmons WA, Breban M, Hammer RE: Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J Immunol 1993, 150:4168-4178.
37. Rich E, Hook E, Alarcon G, Moreland L: Reactive arthritis in patients attending an urban sexually transmitted diseases clinic. Arthritis Rheum 1996, 39:1172-1177. Mild reactive arthritis is a common complication of nongonococcal urethritis and is not associated with HLA-B27.
38. Glennas A, Kvien TK, Melby K, Overboo A, Andrup O, Karstensen B, Thoen JE: Reactive arthritis: a favorable 2 year course and outcome, independent of triggering agent and HLA-B27. J Rheumatol 1994, 21:2274-2280.
39. Calin A, Marder A, Marks S, Burns T: Familial aggregation of Reiter's syndrome and ankylosing spondylitis: a comparative study. J Rheumatol 1984, 11:672-677.
40. Li F, Bulbul R, Schumacher HR Jr, Kieber Emmons T, Callegari PE, Von Feldt JM, Norden D, Freundlich B, Wang B, Imonitie V, et al.: Molecular detection of bacterial DNA in venereal-associated arthritis. Arthritis Rheum 1996, 39:950-958. Bacterial DNA was detected by polymerase chain reaction in synovial fluid and tissue in patients with inflammatory arthropathies, including reactive arthritis.
41. Bas S, Griffais R, Kvien TK, Glennas A, Melby K, Vischer TL: Amplification of plasmid and chromosome chlamydia DNA in synovial fluid of patients with reactive arthritis and undifferentiated seronegative oligoarthropathies. Arthritis Rheum 1995, 38:1005-1013.
42. Robinson WP, van dLS, Khan MA, Rentsch HU, Cats A, Russell A, Thomson G: HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients [see comments]. Arthritis Rheum 1989, 32:1135-1141.
43. Vargas-Alarcon G, Garcia A, Bahena S, Melin-Aldana H, Andrade F, Ibanez-de-Kasep G, Alcocer-Varela J, Alarcon-Segovia D, Granados J: HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies. Ann Rheum Dis 1994, 53:755-758.
44. Reveille JD, Suarez-Almazor ME, Russell AS, Go RC, Appleyard J, Barger BO, Acton RT, Koopman WJ, McDaniel DO: HLA in ankylosing spondylitis: is HLA-B27 the only MHC gene involved in disease pathogenesis? Semin Arthritis Rheum 1994, 23:295-309.
45. Sanmarti R, Canete JD, Collado A, Ercilla MG, Brancos MA, Munoz GJ: Comment on the article by Robinson et al [letter; comment]. Arthritis Rheum 1991, 34:247-248.
46. Yamaguchi A, Tsuchiya N, Mitsui H, Shiota M, Ogawa A, Tokunaga K, Yoshinoya S, Juji T, Ito K: Association of HLA-B39 with HLA-B27-negative ankylosing spondylitis and pauclarticular juvenile rheumatoid arthritis in Japanese patients: evidence for a role of the peptide-anchoring B pocket. Arthritis Rheum 1995, 38:1672-1677.
47. Falk K, Rotzschke O, Takiguchi M, Gnau V, Stevanovic S, Jung G, Rammensee H: Peptide motifs of HLA-B58, B60, B61 and B62 molecules. Immunogenetics 1995, 41:165-168.
48. Lopez D, Garcia-Hoyo R, Lopez-de-Castro JA: Clonal analysis of alloreactive T cell responses against the closely related B*2705 and B*2703 subtypes: implications for HLA-B27 association to spondyloarthropathy. J Immunol 1994, 152:5557-5571.
49. Gladman DD, Anhorn KA, Schachter RK, Mervart H: HLA antigens in psoriatic arthritis. J Rheumatol 1986, 13:586-592.
50. Brown M, Bunce M, Calin A, Darke C, Wordsworth P: HLA-B associations of HLA-B27 negative ankylosing spondylitis: comment on article by Yamaguchi et al. Arthritis Rheum 1996, 39:1768-1769. This is a comment on the study by Yamaguchi et al. (Arthritis Rheum 1995, 38:1672-1677). HLA-B39 is not associated with B27-negative ankylosing spondylitis in British patients.
51. Brown M, Bunce M, Calin A, Darke C, Wordsworth P: HLA-B associations of HLA-B27 negative ankylosing spondylitis: comment on article by Yamaguchi et al. Arthritis Rheum 1996, 39:1768-1769. This is a comment on the study by Yamaguchi et al. (Arthritis Rheum 1995, 38:1672-1677). HLA-B39 is not associated with B27-negative ankylosing spondylitis in British patients.
52. Westman P, Leirisalo-Repo M, Partanen J, Koskimies S: A comparative study of HLA genes in HLA-B27 positive ankylosing spondylitis and HLA-B27 positive peripheral reactive arthritis. Arthritis Rheum 1996, 39:943-949. No significant difference was found in HLA-A, B, C, DR, or DQ frequencies of B27-positive ankylosing spondylitis or reactive arthritis patients compared with each other or with healthy B27-positive controls. Insufficient numbers were studied to exclude small to moderate effects.
53. Aki M, Shimbara N, Takashina M, Akiyama K, Kagawa S, Tamura T, Tanahashi N, Yoshimura T, Tanaka K, Ichihara A: Interferon-gamma induces different subunit organizations and functional diversity of proteasomes. J Biochem Tokyo 1994, 115:257-269.
54. Maksymowych WP, Suarez Almazor M, Chou CT, Russell AS: Polymorphism in the LMP2 gene Influences susceptibility to extraspinal disease in HLA-B27 positive Individuals with ankylosing spondylitis. Ann Rheum Dis 1995, 54:321-324.
55. Ploski R, Flato B, Vinje O, Maksymowych W, Forre O, Thorsby E: Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis. Hum Immunol 1995, 44:88-96.
56. Burney RO, Pile KD, Gibson K, Calin A, Kennedy LG, Sinnort PJ, Powis SH, Wordsworth BP: Analysis of the MHC class II encoded components of the HLA class I antigen processing pathway in ankylosing spondylitis. Ann Rheum Dis 1994, 53:58-60.
57. Maksymowych W, Luong M, Wong C, Gorodezky C, Burgos-Vargas R, Hernandez O, Morenott M, Sanchez-Corona J, Ramos-Remus C, Russell A: The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican individuals with ankylosing spondylitis. Arthritis Rheum 1996, 39:3205.
58. Hajeer AH, Worthington J, Silman AJ, Ollier WE: Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis Rheum 1996, 39:1109-1114.
59. Mulcahy B, Waldron Lynch F, McDermott MF, Adams C, Amos CI, Zhu DK, Ward RH, Clegg DO, Shanahan F, Molloy MG, et al.: Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis. Am J Hum Genet 1996, 59:676-683.
60. Powis SJ, Young LL, Barker PJ, Richardson L, Howard JC, Butcher GW: Major histocompatibility complex-encoded ABC transporters and rat class I peptide motifs. Transplant Proc 1993, 25:2752-2753.
61. Westman P, Partanen J, Leirisalorepo M, Koskimies S: TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. Hum Immunol 1995, 44:236-242.
62. Maksymowych WP, Tao S, Li Y, Wing M, Russell AS: Allelic variation at the TAP 1 locus influences disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis. Tissue Antigens 1995, 45:328-332.
63. Barron KS, Reveille JD, Carrington M, Mann DL, Robinson MA: Susceptibility to Reiter's syndrome is associated with alleles of TAP genes. Arthritis Rheum 1995, 38:684-689.
64. Obst R, Armandola E, Nijenhuis M, Momburg F, Hammerling G: TAP polymorphism does not influence transport of peptide variants in mice and humans. Eur J Immunol 1995, 25:2170-2176.
65. Brown MA, Pile KD, Klinke J, Gibson K, Bunce M, Calin A, Darke C, Davis J, Wordsworth BP: HLA class II associations of ankylosing spondylitis [abstract]. Br J Rheumatol 1995, 34(suppl 1):146.
66. Roussomousstakaki M, Satsangi J, Welsh K, Louis E, Fanning G, Targan S, Landers C, Jewell D: Genetics of ulcerative colitis: HLA DRB1*0103 (DR103) is associated with extraintestinal manifestations and the need for surgery. Gastroenterology 1997, in press.
67. Laivoranta S, Ilonen J, Tuokko J, Luukkainen R, Toivanen A: HLA frequencies in HLA-B27 negative patients with reactive arthritis. Clin Exp Rheumatol 1995, 13:637-640.
68. Monowarul Islam SM, Numaga J, Fujino Y, Masuda K, Ohda H, Hirata R, Maeda H, Mitsui H: HLA-DR8 and acute anterior uveitis in ankylosing spondylitis. Arthritis Rheum 1995, 38:547-550.
69. Muto M, Nagai K, Mogami S, Nakano J, Sasazuki T, Asagami C: HLA antigens in Japanese patients with psoriatic arthritis. Tissue Antigens 1995, 45:362-364.
70. Ploski R, Maksymowych W, Forre O: HLA-DR8 and susceptibility to acute anterior uveitis in ankylosing spondylitis: comment on the article by Monowarul Islam et al [letter]. Arthritis Rheum 1996, 39:351-352. This is a comment on the study by Monowarul Islam et al. (Arthritis Rheum 1995, 38:547-550). HLA-DR8, which is associated with juvenile but not adult ankylosing spondylitis in Finland, and may be associated with younger age of onset in Japanese patients with ankylosing spondylitis.
71. Ploski R, Maksymowych W, Forre O: HLA-DR8 and susceptibility to acute anterior uveitis in ankylosing spondylitis: comment on the article by Monowarul Islam et al [letter]. Arthritis Rheum 1996, 39:351-352. This is a comment on the study by Monowarul Islam et al. (Arthritis Rheum 1995, 38:547-550). HLA-DR8, which is associated with juvenile but not adult ankylosing spondylitis in Finland, and may be associated with younger age of onset in Japanese patients with ankylosing spondylitis.
72. Brown M, Kennedy L, Darke C, Gibson K, Klinke J, Pile K, Taylor A, Calin A, Wordsworth B: HLA Class II associations of ankylosing spondylitis. J Rheumatol 1997: in press.
73. La NG, Mathieu A, Mulargia M, Carcassi C, Vacca A, Ledda A, Contu L: Association of the HLA-A2, CW2, B27, S31, DR2 haplotype with ankylosing spondylitis: a possible role of non-B27 factors in the disease. Dis Markers 1993, 11:191-203.
74. Lopez D, Barber D, Villadangos J, Lopez de Castro J: Cross-reactive T cell clones from unrelated individuals reveal similarities in peptide presentation between HLA-B27 and HLA-DR2. J Immunol 1993, 150:2675-2686.
75. Miehle W, Schattenkirchner M, Albert D, Bunge M: HLA-DR4 in ankylosing spondylitis with different patterns of joint involvement. Ann Rheum Dis 1985, 44:39-44.
76. Sanmarti R, Ercilla MG, Brancos MA, Cid MC, Collado A, Rotes Querol J: HLA class II antigens (DR, DQ loci) and peripheral arthritis in ankylosing spondylitis. Ann Rheum Dis 1987, 46:497-500.
77. Armstrong RD, Panayi GS, Welsh KI: Histocompatibility antigens in psoriasis, psoriatic arthropathy, and ankylosing spondylitis. Ann Rheum Dis 1983, 42:142-146.
78. Aaron S, Miller ML, Howard J, Fraser PA, Jackson JM, Larson MG, Glass DN: Complementation with HLA-A and HLA-D locus alleles in ankylosing spondylitis with peripheral arthritis. J Rheumatol 1985, 12:553-557.
79. Sakkas L, Loqueman N, Bird H, Vaughan R, Welsh K, Panayi G: HLA Class II and T cell receptor gene polymorphisms in psoriatic arthritis and psoriasis. J Rheumatol 1990, 17:1487-1490.
80. Gladman D, Farewell V: The role of HLA antigens as indicators of disease progression in psoriatic arthritis. Arthritis Rheum 1995, 38:845-850.
81. Tuokko J, Reijonen H, Ilonen J, Anttila K, Nikkari S, Mottonen T, Yli-Kertulla U, Toivanen A: Increase of HLA-DRB1*O408 and -DQB1*0301 in HLA-B27 positive reactive arthritis. Ann Rheum Dis 1997, 56:37-41. Association of the rare DRB1*0408-DQB1*0301 haplotype was reported in patients with reactive arthritis compared with the general population, but not compared with B27-positive healthy controls. The finding may reflect linkage disequilibrium between B27 and DR-DQ.
82. Brewerton DA, Webley M, Murphy AH, Ward AM: The alpha 1-antitrypsin phenotype MZ in acute anterior uveitis [letter]. Lancet 1978, i:1103.
83. Kijlstra A, Linssen A, Ockhuizen T: Association of Gm allotypes with the occurrence of ankylosing spondylitis in HLA-B27-positive anterior uveitis. Am J Ophthalmol 1984, 98:732-735.
84. Linssen A, Rothova A, Broekema N, Derhaag PJ, Luyendijk L, De Lange GG, Van Eede PH, Van Leeuwen AM, Frants R, Kruit PJ, et al.: Genes on chromosome 14q and their role in the pathogenesis of HLA-B27 associated diseases. Clin Exp Rheumatol 1987, 5:392-395.
85. Tiilikainen A, Koskimies S, Eriksson A, Frants R: Genetic background of acute anterior uveitis. Am J Ophthalmol 1981, 91:711-720.
86. Moller P, Fagerhol MK: Pi phenotypes in patients with ankylosing spondylitis, acute anterior uveitis, psoriasis and chronic prostatitis. Clin Genet 1984, 26:339-341.
87. Beyeler C, Armstrong M, Bird HA, Idle JR, Daly AK: Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 1996, 55:66-68. An association between an allele of CYP2D6 and ankylosing spondylitis was found. No correction was made for multiple statistical comparisons.
88. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996, 273:1516-1521. Reviews the limitations of linkage and association studies in complex human genetic diseases.
89. Risch N: Linkage strategies for genetically complex traits: II: the power of affected relative pairs [see comments]. Am J Hum Genet 1990, 46:229-241.
90. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gouch SCL, Jenkins SC, Palmer SM: A genome-wide search for human type I diabetes susceptibility genes. Nature 1994, 371:130-137.
91. Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, Terwilliger J, Lathop GM, Bell JI, Jewell DP: Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosome 3, 7, and 12. Nat Genet 1996, 14:199-202. Genetic susceptibility to inflammatory bowel disease was investigated by a genome-wide search using microsatsllite markers, demonstrating the potential for this methodology to dissect complex human genetic diseases.
92. de Jongh BM, van der Linden SM, Volkers WS, Cats A: Genetics of non-HLA marker genes in HLA-B27-positive and -negative ankylosing spondylitis families. Scand J Rheumatol Suppl 1990, 87:127-130.
93. Brown MA, Pile KD, Kennedy LG, Andrew L, Butcher S, Gibson K, Nicod A, Shatford J, Walsh S, March RE, et al.: Genome wide screen in ankylosing spondylitis. Br J Rheumatol 1997, 36(suppl1).