Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma

Clinical Cancer Research

Volumn 2, Issue 1, 1996, Pages 161-173

  Lai, Paola ^b,d   Rabinowich, Hannah ^a,b   Crowley Nowick, Peggy A ^a   Bell, Maria C ^c   Mantovani, Giovanni ^d   Whiteside, Theresa L ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; NATURAL KILLER CELL; OVARY CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR ASSOCIATED LEUKOCYTE;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); LYMPHOCYTES, TUMOR-INFILTRATING; MEMBRANE PROTEINS; MIDDLE AGED; OVARIAN NEOPLASMS; PHOSPHOLIPASE C; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IGE; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TYROSINE;

EID: 0030035046     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Sedlmayr, P., Rabinowich, H., Winkelstein, A., Herberman, R. B., and Whiteside, T. L. Generation of adherent lymphokine activated killer (A-LAK) cells from patients with acute myelogenous leukaemia. Br. J. Cancer, 65: 222-228, 1992.
2. Broder, S., and Waldmann, T. A. The suppressor-cell network in cancer. N Engl. J. Med., 299: 1281-1284, 1978.
3. Miescher, S., Whiteside, T. L., Moretta, L., and Von Fliedner, V. Clonal and frequency analyses of tumor infiltrating T lymphocytes from human solid tumors. J. Immunol., 138: 4004-4011, 1987.
4. Miescher, S., Whiteside, T. L., Carrel, W. T. L. S., and Von Fliedner, V. Functional properties of tumor infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J. Immunol., 136: 1899-1907, 1986.
5. Miescher, S., Stoeck, M., Qiao, L., Barras, C., Barrelet, L., and Von Fliedner, V. Preferential clonogenic deficit of CD8-positive T lymphocytes infiltrating human solid tumors Cancer Res., 48: 6992-6998, 1988.
6. Miescher, S., Stoeck, M., Qiao, L , Barras, C , Barrelet, L., and Von Fliedner, V. Proliferative and cytolytic potentials of purified human tumor infiltrating T lymphocytes. Impaired response to mitogen-driven stimulation despite T cell receptor expression. Int. J. Cancer. 42: 659-666, 1988.
7. Webb, S., Morris, C., and Sprent, J. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell, 63: 1249-1256, 1990.
8. Jenkins, M. K., and Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T-cell unresponsiveness in vivo and in vivo. J. Exp. Med., 165: 302-319, 1987.
9. Kirchner, H. Suppressor cells of immune reactivity in malignancy. Eur. J. Cancer, 14, 453-459, 1978.
10. Fujimoto, S., Greene, M. I., and Sehon, A. H. Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts. J Immunol., 116: 791-799, 1976.
11. Fuji, T., Igarashi, T., and Kishimoto, S. Significance of suppressor macrophages for immune surveillance of tumor-bearing mice. J. Natl. Cancer Inst., 78: 509-517, 1987.
12. Yoshino, I., Yano, T., Murata, M., Ishida, T., Sugimachi, K., Kimura, G., and Nomoto, K Tumor-reactive T-cell accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor. Cancer Res., 52: 775-781, 1992.
13. Ebert, E. C., Roberts, A. I., O'Connell, S. M , Robertson, F. M., and Nagase, H. Characterization of an immunosuppressive factor derived from colon cancer cells. J. Immunol., 138: 2161-2168, 1987.
14. Roth, J. A., Osborne, B. A., and Ames, R. S. Immunoregulatory factors derived from human tumors. II. Partial purification and further immunochemical characterization of a human sarcoma-derived immunosuppressive factor expressing HLA-DR and immunoglobulin-related determinants. J. Immunol., 130: 303-308, 1983.
15. Mizoguchi, H., O'Shea, J. J., Longo, D. L., Loeffler, D. M., McVicar, D. W., and Ochoa, A. C. Alteration in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (Washington DC), 258: 1795-1798, 1992.
16. + T cells. J. Immunol., 149: 949-956, 1992.
17. lck in T-cell infiltrating human renal cell carcinoma. Cancer Res., 53: 5613-5616, 1993.
18. Nakagorni, H., Petersson, M., Magnusson, I., Juhlin, C., Matsuda, M., Mellstedt, H., Taupin, J-L., Vivier, E., Anderson, P., and Kiessling, R. Decreased expression of the signal-transducing ζ chains in tumor-infiltrating T-cell and NK cells of patients with colorectal carcinoma. Cancer Res., 53: 5610-5612, 1993.
19. Ioannides, C. G., Platsoucas, C. D., Hashed, S., Wharton, J. T., Edwards, C. L., and Freedman, R. S. Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites. Cancer Res., 51: 4257-4265, 1991.
20. Julius, M. H., Simpson, E., and Herzenberg, L. A. A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol., 3: 645-649, 1973.
21. Rabinowich, H., Pricop, L., Herberman, R. B., and Whiteside, T. L. Expression and function of CD7 molecule on human natural killer (NK) cells. J. Immunol., 152: 517-526, 1994.
22. Rabinowich, H., Sedlmayr, P., Herberman, R. B., and Whiteside, T. L. Increased proliferation, lytic activity and purity of natural killer cells co-cultured with mitogen-activated feeder cells. Cell. Immunol., 135: 454-470, 1991.
23. Laemmli, U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond), 227: 680-685, 1970.
24. Whiteside, T. L. Cytokines and cytokine measurements in a clinical laboratory. Clin. Diagn. Lab. Immunol., 1: 257-260, 1994
25. Anderson, P., Caligiuri, M., Ritz, J., and Schlossman, S. F. CD3-natural killer cells express zeta TcR as part of a novel molecular complex. Nature (Lond.). 341: 159-162, 1989.
26. Biassoni, R., Ferrini, S., Prigione, I., Moretta, A., and Long, E. O. CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene. J. Immunol., 140: 1685-1689, 1988.
27. Lanier, L. L., Chang, C., Spits, H., and Phillips, J. H. Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. J. Immunol., 149: 1876-1880, 1992.
28. Matsuda, M., Petersson, M., Lenkei, R., Raupin, J-L., Magnusson, I., Mellstedt, H., Anderson, P., and Kiessling, R. Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int. J Cancer, 61: 765-772, 1995.
29. Chan, A. C., Desai, D. M., and Weiss, A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol., 12: 555-592, 1994.
30. Ohno, H., Ono, S., Hirayama, N., Shimada, S., and Saito, T. Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia. J. Exp. Med., 179: 365-369, 1994.
31. Alexander, J. P., Kudoh, S., Melsop, K. A., Hamilton, T. A., Edinger, M. G., Tubbs, R. R., Sica, D., Tuason, I., Klein, E., Bukowski, R. M., and Finke, J. H. T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors. Cancer Res., 53: 1380-1387, 1993.
32. Whiteside, T. L. Tumor-Infiltrating Lymphocytes in Human Malignancies. Austin: R. G. Landes Co., 1993.
33. Applegate, K. G , Balch, C. M , and Pellis, N R. In vitro migration of lymphocytes through collagen matrix: arrested locomotion in tumor-infiltrating lymphocytes. Cancer Res., 50: 7153-7158, 1990.
34. Vitolo, D., Zerbe, T., Kanbour, A , Dahl, C., Herberman, R. B., and Whiteside, T. L. Expression of mRNA for cytokines in tumor-infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer. Int. J. Cancer, 51: 573-580, 1992.
35. Vitolo, D., Letessier, E. M., Johnson, J. T., and Whiteside, T. L. Immunologic effector cells in head and neck cancer. Monogr. Natl. Cancer Inst., 13: 203-208, 1992
36. Ghosh, P., Sica, A., Young, H. A., Ye, J., Franco, J. L., Wiltrout, R. H., Longo, D. L., Rice, N. R., and Comschlies, K. L Alterations in NFκB/Rel family proteins in specific T-cells from tumor-bearing mice and reversal following therapy. Cancer Res., 54: 2969-2972, 1994.
37. Letourneur, F., and Klausner, R. D. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3ε. Science (Washington DC), 255: 79-82, 1992.
38. Madrenas, J., Wange, R. L., Wang, J. L., Isakov, N., Samelson, L. E., and Germain, R. N. ζ phosphorylation without ZAP-70 activation induced by TcR antagonists or partial agonists. Science (Washington DC), 207: 515-518. 1995.
39. Sloan-Lancaster, J., Shaw, A. S., Rothbard, J. B., and Allen, P. M. Partial T cell signaling: altered phospho-ζ and and lack of Zap70 recruitment in APC-induced T cell anergy. Cell, 79: 913-922, 1994.
40. Racioppi, L., Ronchese, F., Matis, L. A., and Germain, R. N. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med., 177: 1047-1060, 1993.
41. Weiss, A., and Littman, D. R. Signal transduction by lymphocyte antigen receptors. Cell, 76: 263-274, 1994.
42. Ravichandran, K. S., Lee, K. K., Songyang, Z., Cantley, L. C., Burn, P., and Burakoff, S. J. Interaction of Sch with ζ chain of the T cell receptor upon T cell activation. Science (Washington DC), 262: 902-905, 1993.
43. Exley, M., Varticovski, L., Peter, M., Sancho, J., and Terhorst, C. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation. J. Biol. Chem., 269: 15140-15146, 1994.
44. Janeway, C. A., Jr. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol., 10: 645-674, 1992.
45. lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T cell line. Mol. Cell. Biol., 12: 4521-4530, 1992.
46. Straus, D. B., and Weiss, A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor Cell, 70: 585-593, 1992.
47. Li, X , Liu, J., Park, J-K., Hamilton, T. A., Rayman, P., Klein, E., Edinger, M., Tubbs, R., Bukowski, R., and Finke, J. T cells from renal cell carcinoma patients exhibit an abnormal pattern ofκB-specific DNA binding activity: a preliminary report. Cancer Res., 54: 5424-5429, 1994.
48. Liou, H. C., and Baltimore, D. Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr. Opin. Cell Biol., 5: 477-487, 1993.
49. Quill, H., Riley, M. P., Cho, E. A., Casnellie, J. E., Reed, J. C., and Torigoe, T. Anergic Th1 cells express altered levels of the protein tyrosine kinases p561ck and p59fyn. J. Immunol , 149: 2887-2893, 1992.
50. Taupin, J-L., and Anderson, P. Activation-induced proteolysis of the cytoplasmic domain of ζ in T cell receptors and Fc receptors. Eur. J. Immunol., 24: 3000-3004, 1994.
51. Paolini, R., and Kinet, J-P. Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors. EMBO J., 12: 779-786, 1993.
52. Cenciarelli, C., Hou, D., Hsu, K-C., Rellahan, B. L., Wiest, D. L., Smith, H. T., Fried, V. A., and Weissman, A. M. Activation-induced ubiquitination of the T cell antigen receptor. Science (Washington DC), 257: 795-797, 1992.
53. Hershko, A., and Ciechanover, A. The ubiquitin system for protein degradation. Annu. Rev. Biochem., 61: 761-807, 1992.
54. Gansbacher, B., Zier, K., Daniels, B., Cronin, K., Bannerji, R., and Gilboa, E. Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protected immunity. J. Exp. Med., 172: 1217-1224, 1990.
55. Salvadori, S., Gansbacher, B., Pizzimenti, A. M., and Zier, K. S. Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL2-secreting tumors. J. Immunol., 153: 5176-5183, 1994.