Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family

Journal of Cellular Biochemistry

Volumn 64, Issue 4, 1997, Pages 586-594

  Dou, Q Ping ^a,b   An, Bing ^a,b   Antoku, Keiko ^a,b   Johnson, Daniel E ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

apoptosis; Fas; ICE; protease; RB

Indexed keywords

DNA FRAGMENT; FAS ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; NERVE GROWTH FACTOR RECEPTOR; RETINOBLASTOMA PROTEIN; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL ONCOGENE; DEPHOSPHORYLATION; ENZYME INHIBITION; ETIOLOGY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INHIBITION KINETICS; LEUKEMIA CELL LINE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ANTIGENS, CD95; APOPTOSIS; CASPASE 1; CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JURKAT CELLS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN;

EID: 0030943468     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19970315)64:4<586::AID-JCB7>3.0.CO;2-N     Document Type: Article

References (47)

1. Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM (1995): Deficiency of retinoblastoma proteins leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci USA 92:5436-5440.
2. An B, Dou QP (1996): Cleavage of retinoblastoma protein during apoptosis: An interleukin 1β-converting enzyme-like protease as candidate. Cancer Res 56:438-442.
3. Boldin MP, Goncharov TM, Goltsev YV, Wallach D (1996): Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF-receptor-induced cell death. Cell 85:803-815.
4. Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, Huebner K, Black RA (1992): Molecular cloning of the interleukin-1β converting enzyme. Science 256:97-100.
5. Clarke AR, Maandag ER, van Roon M, van der Lugt NMT, van der Valk M, Hooper ML, Berns A, and te Riele H (1992): Requirement for a functional Rb-1 gene in murine development. Nature 359:328-330.
6. 1 arrest and apoptosis. Proc Natl Acad Sci U S A 92:9019-9023.
7. Ellis RE, Yuan J, Horvitz HR (1991): Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698.
8. Enari M, Hug H, Nagata S (1995): Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375: 78-81.
9. Enari M, Talanian RV, Wong WW, Nagata S (1996): Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723-726.
10. Field SJ, Tsai F-Y, Kuo F, Zubiaga AM, Kaelin WG Jr, Livingston DM, Orkin SH, and Greenberg ME (1996): E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549-561.
11. Fraser A, Evan G (1996): A license to kill. Cell 85:781-784.
12. Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T'Ang A, Fung Y-KT, Israel MA (1995): Inhibition of apoptosis by the retinoblastoma gene product. EMBO J 14:461-472.
13. Hasegawa J-I, Kamada S, Kamiike W, Shimizu S, Imazu T, Matsuda H, Tsujimoto Y (1996): Involvement of CPP32/ Yama(-like) proteases in Fas-mediated apoptosis. Cancer Res 56:1713-1718.
14. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, Hase A, Seto Y, Nagata S (1991): The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243
15. Itoh N, Tsujimoto Y, Nagata S (1993): Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol 151:621-627.
16. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992): Effects of an Rb mutation in the mouse. Nature 359:295-300.
17. Komiyama T, Ray CA, Pickup DJ, Howard AD, Thornberry NA, Peterson EP, Salvesen G (1994): Inhibition of interleukin-1β converting enzyme by the cowpox virus serpin CrmA. J Biol Chem 269:19331-19337.
18. Kowalik TF, DeGregori J, Schwartz JK, Nevins JR (1995): E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 69:2491-2500.
19. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS-S, Flavell RA (1995): Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267:2000-2003.
20. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC (1994): Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371:346-347.
21. Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC (1995): Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A 92:9042-9046.
22. Lee EY-HP, Chang C-Y, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee W-H, Bradley A (1992): Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359:288-294.
23. Los M, Van de Craen M, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Droge W, Krammer PH, Fiers W, Schulze-Osthoff K (1995): Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375: 81-83.
24. Martin SJ, Green DR (1995): Protease activation during apoptosis: Death by a thousand cuts? Cell 82:349-352.
25. MacArthur H, Walter G (1984): Monoclonal antibodies specific for the carboxy terminus of simian virus 40 T antigen. J Virol 52:483-491.
26. Miura M, Zhu H, Rotello R, Hartweig EA, Yuan J (1993): Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653-660.
27. Morgenbesser SD, Williams BO, Jacks T, DePinho RA (1994): p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72-74.
28. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM (1996): FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817-827.
29. Nagata S, Golstein P (1995): The Fas death factor. Science 267:1449-1456.
30. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin T-T, Yu VL, Miller DK (1995): Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43.
31. Qin X-Q, Livingston DM, Kaelin WG Jr, Adams PD (1994): Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A 91:10918-10922.
32. Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ (1992): Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme. Cell 69:597-604.
33. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA (1988): Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487-491.
34. Sanger F, Nicklen S, Coulson A (1977): DNA sequencing with chain termination inhibitors. Proc Natl Acad Sci USA 74:5463-5467.
35. Schlegel J, Peters I, Orrenius S, Miller DK, Thornberry NA, Yamin T-T, Nicholson DW (1996): CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem 271:1841-1844.
36. Shan B, Lee W-H (1994): Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol 14:8166-8173.
37. Shimizu S, Eguchi Y, Kamiike W, Matsuda H, Tsujimoto Y (1996): Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12:2251-2257.
38. Slack RS, Skerjanc IS, Lach B, Craig J, Jardine K, McBurney MW (1995): Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. J Cell Biol 129:779-788.
39. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (1995): Cloning and functional analysis of BAG-1: Anovel Bcl-2-binding protein with anti-cell death activity. Cell 80:279-284.
40. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM (1995): Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801-809.
41. Tewari M, Dixit VM (1995): Fas-and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 270:3255-3260.
42. Thompson CB (1995): Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462.
43. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992): Anovel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356:768-774.
44. Trauth BC, Klas C, Peters AMJ, Matzku S, Moller P, Falk W, Debatin K-M, Krammer PH (1989): Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301-305.
45. Wu X, Levine AJ (1994): p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A 91:3602-3606.
46. Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ (1996): Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85:537-548.
47. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993): The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641-652.