메뉴 건너뛰기




Volumn 1, Issue 3, 1999, Pages 323-331

Oligonucleotides as inhibitors of human immunodeficiency virus

Author keywords

[No Author keywords available]

Indexed keywords

FOMIVIRSEN; OLIGONUCLEOTIDE; TRECOVIRSEN; ZINTEVIR;

EID: 0033056726     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (31)

References (93)
  • 1
    • 2442741036 scopus 로고
    • Interferon induction by polynucleotides
    • Carter WA (Ed), CRC Press Cleveland, Ohio
    • Field AK: Interferon induction by polynucleotides. In: Selective Inhibitors of Viral Functions. Carter WA (Ed), CRC Press Cleveland, Ohio (1973):149-176.
    • (1973) Selective Inhibitors of Viral Functions , pp. 149-176
    • Field, A.K.1
  • 3
    • 0005772676 scopus 로고
    • Inhibition of Rous sarcoma virus RNA translation by a specific oligodeoxyribonucleotide
    • Stephenson ML, Zamecnik PC: Inhibition of Rous sarcoma virus RNA translation by a specific oligodeoxyribonucleotide. Proc Natl Acad Sci USA (1978) 75:285-288. • Seminal paper on antisense ONs.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 285-288
    • Stephenson, M.L.1    Zamecnik, P.C.2
  • 4
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik PC, Stephenson ML: Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci USA (1978) 75:280-284. • Seminal papers on antisense ONs.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 280-284
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 5
    • 0030631650 scopus 로고    scopus 로고
    • Antisense inhibition of virus infections
    • August JT (Ed)
    • Kilkuskie RE, Field AK: Antisense inhibition of virus infections. In: Gene Therapy, Advances in Pharmacology, August JT (Ed), (1997) 40:437-483. • Thorough review of antisense ONs as antiviral agents.
    • (1997) Gene Therapy, Advances in Pharmacology , vol.40 , pp. 437-483
    • Kilkuskie, R.E.1    Field, A.K.2
  • 6
    • 0028858531 scopus 로고
    • Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs
    • Azad RF, Brown-Driver V, Buckheit RW Jr, Anderson KP: Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs. Antiviral Res (1995) 28:101-111.
    • (1995) Antiviral Res , vol.28 , pp. 101-111
    • Azad, R.F.1    Brown-Driver, V.2    Buckheit Jr., R.W.3    Anderson, K.P.4
  • 7
    • 0032006475 scopus 로고    scopus 로고
    • Viral targets for antisense oligonucleotiedes: A mini review
    • Field AK: Viral targets for antisense oligonucleotiedes: a mini review. Antiviral Res (1998) 37:67-81.
    • (1998) Antiviral Res , vol.37 , pp. 67-81
    • Field, A.K.1
  • 8
    • 0031036222 scopus 로고    scopus 로고
    • Inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides
    • Jairath S, Vargas PB, Hamlin HA, Field AK, Kilkuskie RE: Inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides. Antiviral Res (1997) 33:201-213. • In situ demonstration of the mechanism of action of an antisense ON.
    • (1997) Antiviral Res , vol.33 , pp. 201-213
    • Jairath, S.1    Vargas, P.B.2    Hamlin, H.A.3    Field, A.K.4    Kilkuskie, R.E.5
  • 9
    • 0029031378 scopus 로고
    • Potent antiviral activity of an antisense oligonucleotide complementary to the intronexon boundary of human cytomegalovirus genes UL36 and UL37
    • Pari GS, Field AK, Smith JA: Potent antiviral activity of an antisense oligonucleotide complementary to the intronexon boundary of human cytomegalovirus genes UL36 and UL37. Antimicrob Agents Chemother (1995) 39:1157-1161. • Fulfilling the criteria of antisense using an antiviral ON.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1157-1161
    • Pari, G.S.1    Field, A.K.2    Smith, J.A.3
  • 10
    • 0030623524 scopus 로고    scopus 로고
    • Advances in understanding the pharmacological properties of antisense oligonucleotides
    • August JT (Ed)
    • Crooke ST: Advances in understanding the pharmacological properties of antisense oligonucleotides. In: Gene Therapy, Advances in Pharmacology. August JT (Ed), (1997) 40:1-49. • Excellent review of the concepts and realities of developing antisense ON drugs.
    • (1997) Gene Therapy, Advances in Pharmacology , vol.40 , pp. 1-49
    • Crooke, S.T.1
  • 12
    • 0029094358 scopus 로고
    • Antisense oligonucleotiedes: Rational drug design for genetic pharmacology
    • Field AK, Goodchild J: Antisense oligonucleotiedes: Rational drug design for genetic pharmacology. Exp Opin Invest Drugs (1995) 4:799-821.
    • (1995) Exp Opin Invest Drugs , vol.4 , pp. 799-821
    • Field, A.K.1    Goodchild, J.2
  • 13
    • 0012073837 scopus 로고    scopus 로고
    • Comparative pharmcokinetics of antisense oligonucleotides
    • Agrawal S (Ed), Humana Press, Totowa, New Jersey
    • Agrawal S, Temsamani J: Comparative pharmcokinetics of antisense oligonucleotides. In: Molecular Medicine: Antisense Therapeutics. Agrawal S (Ed), Humana Press, Totowa, New Jersey (1996):247-270.
    • (1996) Molecular Medicine: Antisense Therapeutics , pp. 247-270
    • Agrawal, S.1    Temsamani, J.2
  • 15
    • 0030581693 scopus 로고    scopus 로고
    • Hairpin antisense oligonucleotides containing 2′-methoxynucleosides with base-pairing in the stem region at the 3′-end: Penetration, localization, and Anti-HIV activity
    • Kuwasaki T, Hosono K, Takai K, Ushijima K, Nakashima H, Saito T, Yamamoto N, Takaku H: Hairpin antisense oligonucleotides containing 2′-methoxynucleosides with base-pairing in the stem region at the 3′-end: penetration, localization, and Anti-HIV activity. Biochem Biophys Res Commun (1996) 228:623-631.
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 623-631
    • Kuwasaki, T.1    Hosono, K.2    Takai, K.3    Ushijima, K.4    Nakashima, H.5    Saito, T.6    Yamamoto, N.7    Takaku, H.8
  • 16
    • 0028342861 scopus 로고
    • Inhibition of human immunodeficiency virus type 1 activity in vitro by oligonucleotides composed entirely of guanosine and thymidine
    • Ojwang J, Elbaggari A, Marshall HB, Jayaraman K, McGrath MS, Rando RF: Inhibition of human immunodeficiency virus type 1 activity in vitro by oligonucleotides composed entirely of guanosine and thymidine. J Acquir Immune Defic Syndr (1994) 7:560-570.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 560-570
    • Ojwang, J.1    Elbaggari, A.2    Marshall, H.B.3    Jayaraman, K.4    McGrath, M.S.5    Rando, R.F.6
  • 17
    • 2442767968 scopus 로고    scopus 로고
    • Oligonucleotides as inhibitors of the human immunodeficiency virus type 1
    • Rando RF: Oligonucleotides as inhibitors of the human immunodeficiency virus type 1. Curr Res Mol Ther (1998) 1:67-75. • Thorough review of ON inhibition of HIV.
    • (1998) Curr Res Mol Ther , vol.1 , pp. 67-75
    • Rando, R.F.1
  • 18
    • 0029164957 scopus 로고
    • Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides
    • Fennewald SM, Rando RF: Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides. J Biol Chem (1995) 270:21718-21721.
    • (1995) J Biol Chem , vol.270 , pp. 21718-21721
    • Fennewald, S.M.1    Rando, R.F.2
  • 19
    • 0028815149 scopus 로고
    • Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix
    • Guvakova MA, Yakubov LA, Vlodavsky I, Tonkinson JL, Stein CA: Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J Biol Chem (1995) 270:2620-2627.
    • (1995) J Biol Chem , vol.270 , pp. 2620-2627
    • Guvakova, M.A.1    Yakubov, L.A.2    Vlodavsky, I.3    Tonkinson, J.L.4    Stein, C.A.5
  • 21
    • 0028001098 scopus 로고
    • Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides
    • Stein CA, Krieg AM: Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides. Antisense Res Dev (1994) 4:67-69. • Suggested criteria for defining antisense activity of ONs.
    • (1994) Antisense Res Dev , vol.4 , pp. 67-69
    • Stein, C.A.1    Krieg, A.M.2
  • 22
    • 0001477721 scopus 로고
    • Inhibition of replication and expression of human T-cell lymphtropic virus type III in cultured cells by exogenous synthetic oligoncleotides complementary to viral RNA
    • Zamecnik PC, Goodchild J, Taguchi Y, Sarin PS: Inhibition of replication and expression of human T-cell lymphtropic virus type III in cultured cells by exogenous synthetic oligoncleotides complementary to viral RNA. Proc Natl Acad Sci USA (1986) 83:4143-4146. • First use of ONs to inhibit HIV replication.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4143-4146
    • Zamecnik, P.C.1    Goodchild, J.2    Taguchi, Y.3    Sarin, P.S.4
  • 24
    • 0343334678 scopus 로고
    • Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues
    • Agrawal S, Ikeuchi T, Sun D, Sarin PS, Konopka A, Maizel J, Zamecnik PC: Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues. Proc Natl Acad Sci USA (1989) 86:7790-7794.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7790-7794
    • Agrawal, S.1    Ikeuchi, T.2    Sun, D.3    Sarin, P.S.4    Konopka, A.5    Maizel, J.6    Zamecnik, P.C.7
  • 25
    • 0027023642 scopus 로고
    • GEM 91 - An antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS
    • Agrawal S, Tang JY: GEM 91 - an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS. Antisense Res Dev (1992) 2:261-266. • First description of GEM-91, later to enter clinical trials against HIV in AIDS patients.
    • (1992) Antisense Res Dev , vol.2 , pp. 261-266
    • Agrawal, S.1    Tang, J.Y.2
  • 26
    • 0027243302 scopus 로고
    • Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates
    • Lisziewicz J, Sun D, Metelev V, Zamecnik P, Gallo RC, Agrawal S: Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates. Proc Natl Acad Sci USA (1993) 90:3860-3864.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3860-3864
    • Lisziewicz, J.1    Sun, D.2    Metelev, V.3    Zamecnik, P.4    Gallo, R.C.5    Agrawal, S.6
  • 27
    • 0028108444 scopus 로고
    • Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells
    • Lisziewicz J, Sun D, Weichold FF, Thierry AR, Lusso P, Tang J, Gallo RC, Agrawal S: Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. Proc Natl Acad Sci USA (1994) 91:7942-7946.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7942-7946
    • Lisziewicz, J.1    Sun, D.2    Weichold, F.F.3    Thierry, A.R.4    Lusso, P.5    Tang, J.6    Gallo, R.C.7    Agrawal, S.8
  • 28
    • 0030935397 scopus 로고    scopus 로고
    • The multiple inhibitory mechanisms of GEM 91, a gag antisense phosphorothioate oligonucleotide, for human immunodeficiency virus type 1
    • Yamaguchi K, Papp B, Zhang D, Ali AN, Agrawal S, Bym RA: The multiple inhibitory mechanisms of GEM 91, a gag antisense phosphorothioate oligonucleotide, for human immunodeficiency virus type 1. AIDS Res Hum Retroviruses (1997) 13:545-554.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , pp. 545-554
    • Yamaguchi, K.1    Papp, B.2    Zhang, D.3    Ali, A.N.4    Agrawal, S.5    Bym, R.A.6
  • 29
    • 0344773153 scopus 로고    scopus 로고
    • Synergistic inhibition of HIV-1 by an antisense oligonucleotide and nucleoside analog reverse transcriptase inhibitors
    • Veal GJ, Agrawal S, Bym RA: Synergistic inhibition of HIV-1 by an antisense oligonucleotide and nucleoside analog reverse transcriptase inhibitors. Antiviral Res (1998) 38:63-73.
    • (1998) Antiviral Res , vol.38 , pp. 63-73
    • Veal, G.J.1    Agrawal, S.2    Bym, R.A.3
  • 30
    • 0024212313 scopus 로고
    • Synthesis of phosphorothioate analogues of oligodeoxynucleotides and their antiviral activity against human immunodeficiency virus (HIV)
    • Matsukura M, Zon G, Shinozuka K, Stein CA, Mitsuya H, Cohen JS, Broder S: Synthesis of phosphorothioate analogues of oligodeoxynucleotides and their antiviral activity against human immunodeficiency virus (HIV). Gene (1988) 72:343-347.
    • (1988) Gene , vol.72 , pp. 343-347
    • Matsukura, M.1    Zon, G.2    Shinozuka, K.3    Stein, C.A.4    Mitsuya, H.5    Cohen, J.S.6    Broder, S.7
  • 31
    • 0000600241 scopus 로고
    • Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells
    • Matsukura M, Zon G, Shinozuka K, Robert-Guroff M, Shimada T, Stein CA, Mitsuya H, Wong-Staal F, Cohen JS, Broder S: Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells. Proc Natl Acad Sci USA (1989) 86:4244-4248.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 4244-4248
    • Matsukura, M.1    Zon, G.2    Shinozuka, K.3    Robert-Guroff, M.4    Shimada, T.5    Stein, C.A.6    Mitsuya, H.7    Wong-Staal, F.8    Cohen, J.S.9    Broder, S.10
  • 32
    • 0028795652 scopus 로고
    • Sequence-specific inhibition of gene expression by a novel antisense oligodeoxynucleotide phosphorothioate directed against a nonregulatory region of the human immunodeficiency virus type 1 genome
    • Anazodo MI, Wainberg MA, Friesen AD, Wright JA: Sequence-specific inhibition of gene expression by a novel antisense oligodeoxynucleotide phosphorothioate directed against a nonregulatory region of the human immunodeficiency virus type 1 genome. J Virol (1995) 69:1794-1801. • Excellent demonstration of antisense ON HIV inhibition.
    • (1995) J Virol , vol.69 , pp. 1794-1801
    • Anazodo, M.I.1    Wainberg, M.A.2    Friesen, A.D.3    Wright, J.A.4
  • 33
    • 0029050107 scopus 로고
    • Sequence-specific inhibition of human immunodeficiency virus (HIV) reverse transcription by antisense oligonucleotides: Comparative study in cell-free assays and in HIV-infected cells
    • Bordier B, Perala-Heape M, Degols G, Lebleu B, Litvak S, Sarih-Cottin L, Helene C: Sequence-specific inhibition of human immunodeficiency virus (HIV) reverse transcription by antisense oligonucleotides: comparative study in cell-free assays and in HIV-infected cells. Proc Natl Acad Sci USA (1995) 92:9383-9387. • Excellent demonstration of antisense ON HIV inhibition.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9383-9387
    • Bordier, B.1    Perala-Heape, M.2    Degols, G.3    Lebleu, B.4    Litvak, S.5    Sarih-Cottin, L.6    Helene, C.7
  • 34
    • 0029804315 scopus 로고    scopus 로고
    • Mechanisms of inhibition of in vitro dimerization of HIV type I RNA by sense and antisense oligonucleotides
    • Skripkin E, Paillart JC, Marquet R, Blumenfeld M, Ehresmann B, Ehresmann C: Mechanisms of inhibition of in vitro dimerization of HIV type I RNA by sense and antisense oligonucleotides. J Biol Chem (1996) 271:28612-28817.
    • (1996) J Biol Chem , vol.271 , pp. 28612-28817
    • Skripkin, E.1    Paillart, J.C.2    Marquet, R.3    Blumenfeld, M.4    Ehresmann, B.5    Ehresmann, C.6
  • 37
    • 0343554657 scopus 로고    scopus 로고
    • Specific inhibition of in vitro reverse transcription using antisense oligonucleotides targeted to the TAR regions of HIV-1 and HIV-2
    • Boulmé F, Perrälä-Heape M, Sarih-Cottin L, Litvak S: Specific inhibition of in vitro reverse transcription using antisense oligonucleotides targeted to the TAR regions of HIV-1 and HIV-2. Biochem Biophys Acta (1997) 1351:249-255.
    • (1997) Biochem Biophys Acta , vol.1351 , pp. 249-255
    • Boulmé, F.1    Perrälä-Heape, M.2    Sarih-Cottin, L.3    Litvak, S.4
  • 38
    • 0032403229 scopus 로고    scopus 로고
    • Modified (PNA, 2′-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as atrong and specific inhibitors of in vitro HIV-1 reverse transcription
    • Boulmé F, Freund F, Moreau S, Nielsen PE, Gryaznov S, Toulmé JJ, Litvak S: Modified (PNA, 2′-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as atrong and specific inhibitors of in vitro HIV-1 reverse transcription. Nucleic Acids Res (1998) 26:5492-5500.
    • (1998) Nucleic Acids Res , vol.26 , pp. 5492-5500
    • Boulmé, F.1    Freund, F.2    Moreau, S.3    Nielsen, P.E.4    Gryaznov, S.5    Toulmé, J.J.6    Litvak, S.7
  • 39
    • 0032485244 scopus 로고    scopus 로고
    • Inhibition of HIV-1 gp120-induced apoptosis in neuroblastoma SK-N-SH cells by an antisense oligodeoxynucleotide against p53
    • Yeung MC, Geertsma F, Liu J, Lau AS: Inhibition of HIV-1 gp120-induced apoptosis in neuroblastoma SK-N-SH cells by an antisense oligodeoxynucleotide against p53. AIDS (1998) 12:349-354.
    • (1998) AIDS , vol.12 , pp. 349-354
    • Yeung, M.C.1    Geertsma, F.2    Liu, J.3    Lau, A.S.4
  • 40
    • 0029872064 scopus 로고    scopus 로고
    • Incorporation of a non-nucleotide bridge into hairpin oligonucleotides capable of high-affinity binding to the Rev protein of HIV-1
    • Nelson JS, Giver L, Ellington AD, Letsinger RL: Incorporation of a non-nucleotide bridge into hairpin oligonucleotides capable of high-affinity binding to the Rev protein of HIV-1. Biochemistry (1996) 35:5339-5344.
    • (1996) Biochemistry , vol.35 , pp. 5339-5344
    • Nelson, J.S.1    Giver, L.2    Ellington, A.D.3    Letsinger, R.L.4
  • 41
    • 0023447274 scopus 로고
    • Phosphorothioate analogs of oligodeoxynucleotides: Inhibitors of replication and cytopathic effects of human immunodeficiency virus
    • Matsukura M, Shinozuka K, Zon G, Mitsuya H, Reitz M, Cohen JS, Broder S: Phosphorothioate analogs of oligodeoxynucleotides: Inhibitors of replication and cytopathic effects of human immunodeficiency virus. Proc Natl Acad Sci USA (1987) 84:7706-7710.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7706-7710
    • Matsukura, M.1    Shinozuka, K.2    Zon, G.3    Mitsuya, H.4    Reitz, M.5    Cohen, J.S.6    Broder, S.7
  • 42
    • 0027288079 scopus 로고
    • Phosphorothioate oligodeoxynucleotides bind to the third variable loop domain (v3) of human immunodeficiency virus type 1 gp120
    • Stein CA, Cleary AM, Yakubov L, Lederman S: Phosphorothioate oligodeoxynucleotides bind to the third variable loop domain (v3) of human immunodeficiency virus type 1 gp120. Antisense Res Dev (1993) 3:19-31. • Demonstration of the mechanism of ON inhibition of virus adsorption.
    • (1993) Antisense Res Dev , vol.3 , pp. 19-31
    • Stein, C.A.1    Cleary, A.M.2    Yakubov, L.3    Lederman, S.4
  • 44
    • 0027967566 scopus 로고
    • Potent and specific inhibition of HIV envelope-mediated cell fusion and virus binding by G quartet-forming oligonucleotide (ISIS 5320)
    • Buckheit Jr RW, Roberson JL, Lackman-Smith C, Wyatt JR, Vickers TA, Ecker DJ: Potent and specific inhibition of HIV envelope-mediated cell fusion and virus binding by G quartet-forming oligonucleotide (ISIS 5320). AIDS Res Hum Retroviruses (1994) 10:1497-1506.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 1497-1506
    • Buckheit Jr., R.W.1    Roberson, J.L.2    Lackman-Smith, C.3    Wyatt, J.R.4    Vickers, T.A.5    Ecker, D.J.6
  • 45
    • 0030200369 scopus 로고    scopus 로고
    • Guanine-rich oligonucleotide modified at the 5′ terminal by dimethoxytrityl residue inhibits HIV-1 replication by specific interaction with the envelope glycoprotein
    • Agatsuma T, Yamamoto I, Furukawa H, Nishigaki T: Guanine-rich oligonucleotide modified at the 5′ terminal by dimethoxytrityl residue inhibits HIV-1 replication by specific interaction with the envelope glycoprotein. Antiviral Res (1996) 31:137-148.
    • (1996) Antiviral Res , vol.31 , pp. 137-148
    • Agatsuma, T.1    Yamamoto, I.2    Furukawa, H.3    Nishigaki, T.4
  • 46
    • 0030471431 scopus 로고    scopus 로고
    • Polydeoxyguanine motifs in a 12-mer phosphorothioate oligodeoxynucleotide augment binding to the v3 loop of HIV-1 gp120 and potency of HIV-1 inhibition independently of G-tetrad formation
    • Lederman S, Sullivan G, Benimetskaya L, Lowy I, Land K, Khaled Z, Cleary AM, Yakubov L, Stein CA: Polydeoxyguanine motifs in a 12-mer phosphorothioate oligodeoxynucleotide augment binding to the v3 loop of HIV-1 gp120 and potency of HIV-1 inhibition independently of G-tetrad formation. Antisense Nucleic Acid Drug Dev (1996) 6:281-289.
    • (1996) Antisense Nucleic Acid Drug Dev , vol.6 , pp. 281-289
    • Lederman, S.1    Sullivan, G.2    Benimetskaya, L.3    Lowy, I.4    Land, K.5    Khaled, Z.6    Cleary, A.M.7    Yakubov, L.8    Stein, C.A.9
  • 48
    • 0028607441 scopus 로고
    • Mechanism of inhibition of HIV-1 infection in vitro by guanine-rich oligonucleotides modified at the 5′ terminal by dimethoxytrityl residue
    • Furukawa H, Momota K, Agatsuma T, Yamamoto I, Kimura S, Shimada K: Mechanism of inhibition of HIV-1 infection in vitro by guanine-rich oligonucleotides modified at the 5′ terminal by dimethoxytrityl residue. Nucleic Acids Res (1994) 22:5621-5627.
    • (1994) Nucleic Acids Res , vol.22 , pp. 5621-5627
    • Furukawa, H.1    Momota, K.2    Agatsuma, T.3    Yamamoto, I.4    Kimura, S.5    Shimada, K.6
  • 52
    • 0027181518 scopus 로고
    • Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides
    • Hatta T, Kim S-G, Nakashima H, Yamamoto N, Sakamoto K, Yokoyama S, Takaku H: Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides. FEBS Lett (1993) 330:161-164.
    • (1993) FEBS Lett , vol.330 , pp. 161-164
    • Hatta, T.1    Kim, S.-G.2    Nakashima, H.3    Yamamoto, N.4    Sakamoto, K.5    Yokoyama, S.6    Takaku, H.7
  • 53
    • 0026502330 scopus 로고
    • Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides
    • Boiziau C, Thuong NT, Toulmé J-J: Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides. Proc Natl Acad Sci USA (1992) 89:768-772.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 768-772
    • Boiziau, C.1    Thuong, N.T.2    Toulmé, J.-J.3
  • 55
    • 0027474318 scopus 로고
    • Phosphorodithioate DNA as a potential therapeutic drug
    • Marshall WS, Caruthers MH: Phosphorodithioate DNA as a potential therapeutic drug. Science (1993) 259:1564-1570.
    • (1993) Science , vol.259 , pp. 1564-1570
    • Marshall, W.S.1    Caruthers, M.H.2
  • 56
    • 0026627889 scopus 로고
    • Inhibition of human immunodeficiency virus type 1 reverse transcriptase by 3′-blocked oligonucleotide primers
    • Austermann S, Kruhoffer M, Grosse F: Inhibition of human immunodeficiency virus type 1 reverse transcriptase by 3′-blocked oligonucleotide primers. Biochem Pharmacol (1992) 43:2581-2589.
    • (1992) Biochem Pharmacol , vol.43 , pp. 2581-2589
    • Austermann, S.1    Kruhoffer, M.2    Grosse, F.3
  • 57
    • 0027931642 scopus 로고
    • Inhibition of HIV-1 reverse transcriptase by defined template/primer DNA oligonucleotides: Effect of template length and binding characteristics
    • Idriss H, Stammers DK: Inhibition of HIV-1 reverse transcriptase by defined template/primer DNA oligonucleotides: effect of template length and binding characteristics. J Enzyme Inhib (1994) 8:97-112.
    • (1994) J Enzyme Inhib , vol.8 , pp. 97-112
    • Idriss, H.1    Stammers, D.K.2
  • 59
    • 0029078816 scopus 로고
    • Phosphorothioate oligonucleotides block reverse transcription by the Rnase H activity associated with the HIV-1 polymerase
    • Hatta T, Takai K, Yokoyama S, Nakashima H, Yamamoto N, Takaku H: Phosphorothioate oligonucleotides block reverse transcription by the Rnase H activity associated with the HIV-1 polymerase. Biochem Biophys Res Commun (1995) 211:1041-1046.
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 1041-1046
    • Hatta, T.1    Takai, K.2    Yokoyama, S.3    Nakashima, H.4    Yamamoto, N.5    Takaku, H.6
  • 60
    • 0030850944 scopus 로고    scopus 로고
    • Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells
    • El Dirani-Diab R, Sarih-Cottin L, Delard B, Dumon B, Moreau S, Toulmé J-J, Fleury H, Litvak S: Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells. Antimicrob Agents Chemother (1997) 41:2141-2148.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2141-2148
    • El Dirani-Diab, R.1    Sarih-Cottin, L.2    Delard, B.3    Dumon, B.4    Moreau, S.5    Toulmé, J.-J.6    Fleury, H.7    Litvak, S.8
  • 61
    • 0028969877 scopus 로고
    • Inhibition of HIV-1 reverse transcription by triple-helix forming oligonucleotides with viral RNA
    • Volkmann S, Jendis J, Frauendorf A, Moelling K: Inhibition of HIV-1 reverse transcription by triple-helix forming oligonucleotides with viral RNA. Nucleic Acids Res (1995) 23:1204-1212.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1204-1212
    • Volkmann, S.1    Jendis, J.2    Frauendorf, A.3    Moelling, K.4
  • 62
    • 0031589213 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract
    • Tsukahara S, Suzuki J, Hiratou T, Takai K, Koyanagi Y, Yamamoto N, Takaku H: Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract. Biochem Biophys Res Commun (1997) 233:742-747.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 742-747
    • Tsukahara, S.1    Suzuki, J.2    Hiratou, T.3    Takai, K.4    Koyanagi, Y.5    Yamamoto, N.6    Takaku, H.7
  • 65
    • 0028961595 scopus 로고
    • Suppression of human immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads
    • Rando RF, Ojwang JO, Elbaggari A, Reyes GR, Tinder R, McGrath MS, Hogan ME: Suppression of human immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads. J Biol Chem (1995) 270:1754-1760. • G quartet formation and the inhibition of HIV.
    • (1995) J Biol Chem , vol.270 , pp. 1754-1760
    • Rando, R.F.1    Ojwang, J.O.2    Elbaggari, A.3    Reyes, G.R.4    Tinder, R.5    McGrath, M.S.6    Hogan, M.E.7
  • 66
    • 0030764882 scopus 로고    scopus 로고
    • Ion selective folding of loop domains in a potent anti-HIV oligonucleotide
    • Jing N, Rando RF, Pommier Y, Hogan ME: Ion selective folding of loop domains in a potent anti-HIV oligonucleotide. Biochemistry (1997) 36:12498-12505.
    • (1997) Biochemistry , vol.36 , pp. 12498-12505
    • Jing, N.1    Rando, R.F.2    Pommier, Y.3    Hogan, M.E.4
  • 67
    • 0029964978 scopus 로고    scopus 로고
    • Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures
    • Mazumder A, Neamati N, Ojwang JO, Sunder S, Rando RF, Pommier Y: Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures. Biochemistry (1996) 35:13762-13771.
    • (1996) Biochemistry , vol.35 , pp. 13762-13771
    • Mazumder, A.1    Neamati, N.2    Ojwang, J.O.3    Sunder, S.4    Rando, R.F.5    Pommier, Y.6
  • 68
    • 0010643916 scopus 로고    scopus 로고
    • Biological activity of guanosine quartet-forming oligonucleotides
    • Stein CA, Krieg AM (Eds), Wiley-Liss Inc
    • Rando RF, Hogan ME: Biological activity of guanosine quartet-forming oligonucleotides. In: Applied Antisense Oligonucleotide Technology. Stein CA, Krieg AM (Eds), Wiley-Liss Inc (1998):335-352.
    • (1998) Applied Antisense Oligonucleotide Technology , pp. 335-352
    • Rando, R.F.1    Hogan, M.E.2
  • 69
    • 0031469736 scopus 로고    scopus 로고
    • Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide
    • Jing N, Gao X, Rando RF, Hogan ME: Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide. J Biomol Struct Dyn (1997) 15:573-585.
    • (1997) J Biomol Struct Dyn , vol.15 , pp. 573-585
    • Jing, N.1    Gao, X.2    Rando, R.F.3    Hogan, M.E.4
  • 70
    • 0032567432 scopus 로고    scopus 로고
    • Structure-activity of tetrad-forming oligonucleotides as a potent anti-HIV therapeutic drug
    • Jing N, Hogan ME: Structure-activity of tetrad-forming oligonucleotides as a potent anti-HIV therapeutic drug. J Biol Chem (1998) 273:34922-34999. • Detailed review of the G quartet formation and the biological activity.
    • (1998) J Biol Chem , vol.273 , pp. 34922-34999
    • Jing, N.1    Hogan, M.E.2
  • 71
    • 0032546568 scopus 로고    scopus 로고
    • Biochemical characterization of the HIV-1 integrase 3′-processing activity and its inhibition by phosphorothioate oligonucleotides
    • Tramontano E, Colla PL, Cheng YC: Biochemical characterization of the HIV-1 integrase 3′-processing activity and its inhibition by phosphorothioate oligonucleotides. Biochemistry (1998) 37:7237-7243.
    • (1998) Biochemistry , vol.37 , pp. 7237-7243
    • Tramontano, E.1    Colla, P.L.2    Cheng, Y.C.3
  • 72
    • 0028786594 scopus 로고
    • The high stability of the triple helices formed between short purine oligonucleotides and SIV/HIV-2 vpx genes is determined by the targeted DNA structure
    • Svinarchuk F, Monnot M, Merle A, Malvy C, Fermandjian S: The high stability of the triple helices formed between short purine oligonucleotides and SIV/HIV-2 vpx genes is determined by the targeted DNA structure. Nucleic Acids Res (1995) 23:3831-3836.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3831-3836
    • Svinarchuk, F.1    Monnot, M.2    Merle, A.3    Malvy, C.4    Fermandjian, S.5
  • 73
    • 0032551544 scopus 로고    scopus 로고
    • Inhibition of replication of drug-resistant HIV type 1 isolates by polypurine tract-specific oligodeoxynucleotide TFO A
    • Jendis J, Strack B, Moelling K: Inhibition of replication of drug-resistant HIV type 1 isolates by polypurine tract-specific oligodeoxynucleotide TFO A. AIDS Res Hum Retroviruses (1998) 14:999-1005.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , pp. 999-1005
    • Jendis, J.1    Strack, B.2    Moelling, K.3
  • 76
    • 0000140697 scopus 로고    scopus 로고
    • Developing antisense oligonucleotides from the laboratory to clinical trials
    • Szymkowski DE: Developing antisense oligonucleotides from the laboratory to clinical trials. Drug Discov Today (1996) 1:415-428. • Interesting review of the practical challenges for practical development of antisense ONs.
    • (1996) Drug Discov Today , vol.1 , pp. 415-428
    • Szymkowski, D.E.1
  • 77
    • 0023734130 scopus 로고
    • Transfer of a functional immune system to mice with severe combined immunodeficiency
    • Mosier DE, Guilizia RJ, Baird SM, Wilson DB: Transfer of a functional immune system to mice with severe combined immunodeficiency. Nature (1988) 335:256-259.
    • (1988) Nature , vol.335 , pp. 256-259
    • Mosier, D.E.1    Guilizia, R.J.2    Baird, S.M.3    Wilson, D.B.4
  • 79
    • 0030902964 scopus 로고    scopus 로고
    • Protection of hu-PBL/beige mice from HIV-1 infection by a 6-mer modified oligonucleotide, R-95288
    • Agatsuma T, Abe K, Furukawa H, Koga R, Koizumi M, Hotoda H, Kaneko M: Protection of hu-PBL/beige mice from HIV-1 infection by a 6-mer modified oligonucleotide, R-95288. Antiviral Res (1997) 34:121-130.
    • (1997) Antiviral Res , vol.34 , pp. 121-130
    • Agatsuma, T.1    Abe, K.2    Furukawa, H.3    Koga, R.4    Koizumi, M.5    Hotoda, H.6    Kaneko, M.7
  • 80
    • 0030797950 scopus 로고    scopus 로고
    • Identification of a phosphodiester hexanucleotide that inhibitis HIV-1 infection in vitro on covalent linkage of its 5′-end with a dimethoxytrityl residue
    • Furukawa H, Momota K, Agatsuma T, Yamamoto I, Kimura S, Shimada K: Identification of a phosphodiester hexanucleotide that inhibitis HIV-1 infection in vitro on covalent linkage of its 5′-end with a dimethoxytrityl residue. Antisense Nucleic Acid Drug Dev (1997) 7:167-175.
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 167-175
    • Furukawa, H.1    Momota, K.2    Agatsuma, T.3    Yamamoto, I.4    Kimura, S.5    Shimada, K.6
  • 82
    • 0028934855 scopus 로고
    • Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1
    • Zhang R, Diasio RB, Lu Z, Liu T, Jiang Z, Galbraith WM, Agrawal S: Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1. Biochem Pharmacol (1995) 49:929-939.
    • (1995) Biochem Pharmacol , vol.49 , pp. 929-939
    • Zhang, R.1    Diasio, R.B.2    Lu, Z.3    Liu, T.4    Jiang, Z.5    Galbraith, W.M.6    Agrawal, S.7
  • 83
    • 0027182233 scopus 로고
    • Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey
    • Cornish KG, Iversen P, Smith P, Ameson M, Bayever E: Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey. Pharmacol Commun (1993) 3:239-247.
    • (1993) Pharmacol Commun , vol.3 , pp. 239-247
    • Cornish, K.G.1    Iversen, P.2    Smith, P.3    Ameson, M.4    Bayever, E.5
  • 84
    • 0028596461 scopus 로고
    • Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey
    • Galbraith WM, Hobson WC, Giclas PC, Schechter PJ, Agrawal S: Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey. Antisense Res Dev (1994) 4:201-206.
    • (1994) Antisense Res Dev , vol.4 , pp. 201-206
    • Galbraith, W.M.1    Hobson, W.C.2    Giclas, P.C.3    Schechter, P.J.4    Agrawal, S.5
  • 85
    • 0031910668 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion
    • Grindel JM, Musick TJ, Jiang Z, Roskey A, Agrawal S: Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion. Antisense Nucleic Acid Drug Dev (1998) 8:43-52.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 43-52
    • Grindel, J.M.1    Musick, T.J.2    Jiang, Z.3    Roskey, A.4    Agrawal, S.5
  • 87
    • 0030302478 scopus 로고    scopus 로고
    • Single-dose hemodynamic toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after intravenous infusion to cynomolgus monkeys
    • Wallace TL, Bazemore SA, Kombrust DJ, Cossum PA: Single-dose hemodynamic toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after intravenous infusion to cynomolgus monkeys. J Pharmacol Exp Ther (1996) 278:1306-1312.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1306-1312
    • Wallace, T.L.1    Bazemore, S.A.2    Kombrust, D.J.3    Cossum, P.A.4
  • 88
    • 0030302474 scopus 로고    scopus 로고
    • Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys
    • Wallace TL, Bazemore SA, Kombrust DJ, Cossum PA: Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys. J Pharmacol Exp Ther (1996) 278:1313-1317.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1313-1317
    • Wallace, T.L.1    Bazemore, S.A.2    Kombrust, D.J.3    Cossum, P.A.4
  • 89
    • 0030615089 scopus 로고    scopus 로고
    • Pharmacokinetics and distribution of a 33P-labeled anti-human immunodeficiency virus oligonucleotide (AR177) after single- and multiple-dose intravenous administration to rats
    • Wallace TL, Bazemore SA, Holm K, Markham PM, Shea JP, Chaudhary N, Cossum PA: Pharmacokinetics and distribution of a 33P-labeled anti-human immunodeficiency virus oligonucleotide (AR177) after single-and multiple-dose intravenous administration to rats. J Pharmacol Exp Ther (1997) 280:1480-1488.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 1480-1488
    • Wallace, T.L.1    Bazemore, S.A.2    Holm, K.3    Markham, P.M.4    Shea, J.P.5    Chaudhary, N.6    Cossum, P.A.7
  • 91
    • 0028131976 scopus 로고
    • Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms
    • Zelphati O, Imbach JL, Signoret N, Zon G, Rayner B, Leserman L: Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms. Nucleic Acids Res (1994) 22:4307-4314.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4307-4314
    • Zelphati, O.1    Imbach, J.L.2    Signoret, N.3    Zon, G.4    Rayner, B.5    Leserman, L.6
  • 92
    • 2442735652 scopus 로고    scopus 로고
    • Will oligonucleotides make effective drugs?
    • Field AK: Will oligonucleotides make effective drugs? Curr Res Mol Ther (1998) 1:65-66.
    • (1998) Curr Res Mol Ther , vol.1 , pp. 65-66
    • Field, A.K.1
  • 93
    • 0342744170 scopus 로고    scopus 로고
    • Synthesis and scale-up of modified oligonucleotides
    • Zhang Z, Tang J-Y: Synthesis and scale-up of modified oligonucleotides. Curr Res Mol Ther (1998) 1:76-84. • Excellent review of the issues and appoaches to ON synthesis and practical large-scale production.
    • (1998) Curr Res Mol Ther , vol.1 , pp. 76-84
    • Zhang, Z.1    Tang, J.-Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.