Antisense oligonucleotides inhibit in vitro cDNA synthesis by HIV-1 reverse transcriptase

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 2, 1996, Pages 103-109

  Boiziau, C ^a   Tarrago Litvak, L ^b   Sinha, N D ^c,d   Moreau, S ^a   Litvak, S ^b   Toulme J J ^a  

^a INSERM   (France)

^b CNRS   (France)

^c MILLIPORE CORPORATION   (United States)

^d PERKINELMER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; OLIGODEOXYNUCLEOTIDE; RNA DIRECTED DNA POLYMERASE;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; RNA CLEAVAGE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0029792115     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.103     Document Type: Article

References (5)

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2. AGRAWAL, S., IKEUCHI, T., SUN, D., SARIN, P.S., KONOPKA, A., MAIZEL, J., and ZAMECNIK, P.C. (1989). Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleoside and their phosphorothioate analogues. Proc. Natl. Acad. Sci. USA 86, 7790-7794.
3. AGRAWAL, S., and TANG, J.Y. (1992). GEM*91 - an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS. Antisense Res. Dev. 2, 261-266.
4. BOIZIAU, C., LARROUY, B., SPROAT, B.C., and TOULMÉ, J.-J. (1995). Antisense 2′-O-alkyl oligoribonucleotides are efficient inhibitors of reverse transcription. Nucleic Acids Res. 23, 64-71.
5. ZELPHATI, O., IMBACH, J.-L., SIGNORET, N., ZON, G., RAYNER, B., and LESERMAN, L. (1994). Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms. Nucleic Acids Res. 22, 4307-4314.