Identification of a phosphodiester hexanucleotide that inhibits HIV-1 infection in vitro on covalent linkage of its 5'-end with a dimethoxytrityl residue

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 167-175

  Furukawa, Hidehiko ^a   Momota, Kenji ^a   Agatsuma, Toshinori ^a   Yamamoto, Ikue ^a   Kimura, Satoshi ^b   Shimada, Kaoru ^c  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Tokyo Senbai Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; GLYCOPROTEIN GP 120; GUANOSINE; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; SA 1042; TRITYL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; VIRUS CELL INTERACTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030797950     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.167     Document Type: Article

References (4)

1. AGATSUMA, T., YAMAMOTO, I., FURUKAWA, H., and NISHIGAKI, T. (1996). Guanine-rich oligonucleotide modified at the 5′ terminal by dimethoxytrityl residues inhibits HIV-1 replication by specific interaction with the envelope glycoprotein. Antiviral Res. 50, 138-148.
2. BARRE-SINOUSSI, F., CHERMANN, J.C., REY, F., NUGEYRE, M.T., CHAMARET, S., GRUEST, J., DAUGET, C., AXLER-BIN, C., VEZINET-BRUIN, F., ROUZIOUX, C., ROSENBAUM, W., and MONTAGNIER, L. (1983). Isolation of a T-lymphocyte retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science 220, 868-871.
3. CHESEBRO, B., NISHIO, J., FERRYMAN, S., CANN, A., O'BRIEN, W., CHEN, I.S., and WEHRLY, K. (1991). Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages. J. Virol. 65, 5782-5789.
4. DALGLEISH, A.G., BEVERLY, P.C.L., CLAPHAM, P.R., CRAWFORD, D.H., GREAVES, M.F., and WEISS, R.A. (1984). The CD4 (T4) antigen is an essential component of the receptor for the AIDS virus. Nature 312, 763-767.