II. Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 3, 1996, Pages 1313-1317

  Wallace, Thomas L ^a   Bazemore, Scott A ^a   Kornbrust, Douglas J ^b   Cossum, Paul A ^a  

^a Antigenics Inc   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PHOSPHOROTHIOIC ACID; UNCLASSIFIED DRUG; ZINTEVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INTEGRASE INHIBITOR; OLIGONUCLEOTIDE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; HEMODYNAMIC MONITORING; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; TOXICITY TESTING; VIRUS INHIBITION; ANIMAL; BLOOD; BLOOD CLOTTING; DRUG EFFECT; ELECTROCARDIOGRAPHY; MACACA;

ANIMALS; ANTI-HIV AGENTS; BLOOD COAGULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HIV INTEGRASE INHIBITORS; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; OLIGONUCLEOTIDES; PARTIAL THROMBOPLASTIN TIME;

EID: 0030302474     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

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