Polydeoxyguanine motifs in a 12-mer phosphorothioate oligodeoxynucleotide augment binding to the v3 loop of HIV-1 gp120 and potency of HIV-1 inhibition independently of G-tetrad formation

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 4, 1996, Pages 281-289

  Lederman, Seth ^a,b   Sullivan, Gregory ^a,b   Benimetskaya, Lyuba ^a   Lowy, Israel ^a   Land, Kevin ^a   Khaled, Zahangir ^a   Cleary, Aileen M ^a   Yakubov, Leonid ^a,c   Stein, C A ^a  

^a Columbia University ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE DERIVATIVE; MONOCLONAL ANTIBODY; OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; POLYDEOXYRIBONUCLEOTIDE; VIRUS GLYCOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING COMPETITION; BINDING KINETICS; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; STRUCTURE ACTIVITY RELATION; VIRUS INFECTIVITY; VIRUS INHIBITION;

EID: 0030471431     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.281     Document Type: Article

References (5)

1. AVRIL, L.E., DI MARTINO-FERRER, M., BRILLARD-BOURDET, M., and GAUTHIER, F. (1995). Inhibition of U-937 membrane-associated cathepsin G by GP120 (IIIB) and v3 loop-derived peptides from several strains of HIV-1. FEBS Lett. 367, 251-256.
2. AVRIL, L.E., DI MARTINO-FERRER, M., PIGNEDE, G., SEMAN, M., and GAUTHIER, F. (1994). Identification of the U-937 membrane-associated proteinase interacting with the v3 loop of HIV-1 gp120 as cathepsin G. FEBS Lett. 345, 81-86.
3. BABA, M., NAKAJIMA, M., SCHOLS, D., PAUWELS, R., BALZARINI, J., and DE CLERCQ, E. (1988). Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 9, 335-343.
4. BUCKHEIT, R.W., JR, ROBERSON, J.L., LACKMAN-SMITH, C., WYATT, J.R., VICKERS, T.A., and ECKER, D.J. (1994). Potent and specific inhibition of HIV envelope-mediated cell fusion and virus binding by G quartet-forming oligonucleotide (ISIS 5320). AIDS Res. Hum. Retroviruses 10, 1497-1506.
5. YAKUBOV, L., KHALED, Z., ZHANG, L.M., TRUNEH, A., VLASSOV, V., and STEIN, C.A. (1993). Oligodeoxynucleotides interact with recombinant CD4 at multiple sites. J. Biol. Chem. 268, 18818-18823.